Navigation Links
New universal breast cancer marker predicts recurrence and clinical outcome
Date:5/6/2009

(PHILADELPHIA) Reporting online in the American Journal of Pathology, researchers from the Kimmel Cancer Center at Jefferson have implicated the loss of a stromal protein called caveolin-1 as a major new prognostic factor in patients with breast cancer, predicting early disease recurrence, metastasis and breast cancer patient survival.

The absence of caveolin-1 in the stroma also appeared to be a marker for drug resistance in patients receiving tamoxifen, according to Michael Lisanti, M.D., Ph.D., professor in the departments of Cancer Biology, Medical Oncology and Biochemistry and Molecular Biology at Jefferson Medical College of Thomas Jefferson University.

According to Dr. Lisanti, who is also director of the Jefferson Stem Cell Biology and Regenerative Medicine Center at the Kimmel Cancer Center, caveolin-1 is expressed by cells in the stroma called fibroblasts, which are present in the connective tissue surrounding cancer cells. When cancer cells arise, the fibroblasts stop making caveolin-1.

"The idea that a prognostic biomarker is present in the stroma rather than the epithelial cancer cell is paradigm-shifting," Dr. Lisanti said. "Importantly, these findings could be developed into a diagnostic test that would not require DNA-based technologies. This inexpensive and cost-effective test would allow doctors to identify high-risk breast cancer patients at diagnosis and treat them more aggressively."

Dr. Lisanti, along with first author Agnieszka Witkiewicz, M.D., assistant professor of Pathology, Anatomy and Cell Biology at Jefferson, and other colleagues analyzed breast tissue samples from 154 women diagnosed with breast cancer. All samples were obtained from the University of Michigan. They used three tissue cores from each patient tumor sample, and analyzed each core for stromal caveolin-1 using immunohistochemistry staining.

The absence of stromal caveolin-1 was strongly associated with other predi
'/>"/>

Contact: Emily Shafer
emily.shafer@jefferson.edu
215-955-6300
Thomas Jefferson University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Universal Health Realty Income Trust Announces Dividend
2. Gentiva(R) Health Services Files Universal Shelf Registration Statement
3. Universal Health Care Coverage in the United States
4. New report: private/public insurance mix is most practical way to achieve universal coverage
5. Universal Health Services, Inc. Reports 2007 Third Quarter Earnings
6. Forum Highlights Role of Private Sector in Achieving Universal Health Coverage in Europe
7. Universal Health Services, Inc. Announces Dividend
8. Internists Diagnose Health Care System Ills, Prescribe Remedies to Achieve Universal Coverage, Better Quality, and Lower Costs
9. Internists diagnose health-care system ills, show how to achieve universal coverage
10. Universal Health Services, Inc. Announces Share Repurchase Authorization
11. Universal Health Services, Inc. Announces Dividend
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/3/2015)... 03, 2015 Motion 5 ... Environment from Pixel Film Studios. , “inMotion3D Environment is ... into 360° viewing area inside Motion 5” said Christina ... the line between professional and amateur making this plugin ... turn their 2D HDRI images into 360° viewing area ...
(Date:3/3/2015)... Salt Lake City, UT (PRWEB) March 03, 2015 ... is an innovative, user-friendly website that focuses ... wilderness therapy, therapeutic boarding schools, and addiction treatment ... Additionally, all residential interventions on the site ... assessments, anxiety, ADHD, autism spectrum disorders, severe learning ...
(Date:3/2/2015)... (PRWEB) March 02, 2015 Formetco today ... billboard design. The FTX uses state-of-the-art technology to ... performance reliability, and owner satisfaction. An item of ... the exclusive Formetco 10 year LED Brightness Warranty. , ... to be a superior billboard among any other billboard ...
(Date:3/2/2015)... 02, 2015 Today at the ... in partnership with the California Healthcare Institute (CHI) ... presented an Assembly resolution recognizing Feb. 28, 2015 ... healthcare professionals caring for millions of Californians living ... nonprofit, public policy research organization, representing leading California ...
(Date:3/2/2015)... 02, 2015 Cutler Integrative Medicine a ... the root, gives cutting-edge tips to bring about self-renewal. ... renew the body by first cleaning house. According ... “We are all Toxic.” Between environmental toxins like heavy ... greatness, and our high stress levels, we all have ...
Breaking Medicine News(10 mins):Health News:A New Plugin Entitled inMotion3D Environment Was Released Today from Pixel Film Studios Exclusively for Motion 5 2Health News:All Kinds of Therapy – New Website for Behavioral Health and Substance Abuse Treatment Launches Today 2Health News:Formetco Launches Innovative LED Billboard System 2Health News:California Healthcare Institute Spotlights Impact of Rare Diseases with Assemblymember Katcho Achadjian 2Health News:California Healthcare Institute Spotlights Impact of Rare Diseases with Assemblymember Katcho Achadjian 3Health News:Skin and Wellness Power Couple give Quick Tips to Self-Renewal for Spring 2
... Cornell University and Dartmouth University have explained the biological ... why people get sleepy at night and wake ... transfers energy from light to chemical reactions in cells, ... even some forms of cancer in humans. ,Circadian ...
... in a gene called FGFR2 could accelerate the development ... uterine cancer. Researchers at Washington University School of Medicine ... (TGen); the Wellcome Trust Sanger Institute, which is part ... Medicine reported the findings in the May 21, 2007, ...
... Taubman lost a good friend to amyotrophic lateral sclerosis ... disease or ALS. ,The memory of watching ... condition has never left Mr. Taubmans mind. And that memory ... of Michigan Medical School and beyond. ,Now, he ...
... Army hospital here has conducted an accident victim's multiple organ ... to three individuals. ,The retrievals were conducted ... and the organs were transplanted Thursday on two patients at ... ,Donor Ramesh Chand, 60, whose two sons serve ...
... the DNA by Watson and Crick the imperious role ... been widely acknowledged. Genes produce an array of proteins, ... individuals functioning or, may coerce other genes to perform ... that adequate research is carried out to understand the ...
... team of engineers, scientists and clinicians from the ... could play a role in heart failure ... ,Patients who have the disease may have narrowed, ... blood flow is blocked and tiny blood clots ...
Cached Medicine News:Health News:Circadian Clocks Triggered Chemical Reactions may Be Behind Jet Lag 2Health News:Gene Discovery Lays Groundwork for Targeted Therapies for Endometrial Cancer 2Health News:Gene Discovery Lays Groundwork for Targeted Therapies for Endometrial Cancer 3Health News:$5M Gift Will Attack Lou Gehrig's Disease 2Health News:$5M Gift Will Attack Lou Gehrig's Disease 3Health News:Army Hospital Conducts First Multiple Organ Retrieval and Transplantation 2Health News:Drink, Binge and the Genetic Link 2Health News:Drink, Binge and the Genetic Link 3Health News:Research may Yield Improved Treatment for Diseased Lungs 2
(Date:3/3/2015)... , March 3, 2015 The European ... defines and segments the concerned market in Europe ... non-invasive & minimally invasive cardiac output monitoring devices market in ... in 2014 and is estimated to grow to $89.8 million ... 2019. Browse through the TOC of European non-invasive ...
(Date:3/2/2015)... 2, 2015 Cure SMA recently announced a new ... Research (CALIBR). This funding is an extension of a spinal ... $700,000 Cure SMA grant to Dr. Peter G. Schultz ... of Small Molecules that Increase SMN2 Levels for ... neuron (SMN) protein is critical to the function of the ...
(Date:3/2/2015)... GLENWOOD, Ill. , March 2, 2015  Landauer, ... in personal and environmental radiation measurement and monitoring, outsourced ... today announced it will release financial results for the ... Monday, March 9, 2015. The Company ... Tuesday, March 10, 2015 at 9:00 a.m. Central Time ...
Breaking Medicine Technology:European Non-Invasive & Minimally Invasive Cardiac Output Monitoring Devices Market is Expected to Reach $89.8 Million by 2019, at a CAGR of 4.2% from 2014 to 2019 2European Non-Invasive & Minimally Invasive Cardiac Output Monitoring Devices Market is Expected to Reach $89.8 Million by 2019, at a CAGR of 4.2% from 2014 to 2019 3Cure SMA Announces $315,000 Grant to California Institute of Biomedical Research 2Cure SMA Announces $315,000 Grant to California Institute of Biomedical Research 3Landauer, Inc. Announces Date and Time for Announcement of Fiscal First Quarter 2015 Results and Conference Call 2
... Genprex, Inc. announced today that it will be presenting at ... San Francisco.   Greg Heinlein , Chief Operating and Financial Officer, ... Forum , on October 25 starting at 11 a.m. PDT in ... be made available on the company,s website under the News & ...
... CINCINNATI, Oct. 20, 2011 Prasco Laboratories , announced ... Eli Lilly and Company (NYSE: LLY ... Tablets and ZYPREXA® ZYDIS (olanzapine) Orally Disintegrating Tablets, in the ... products upon the first ANDA entrant into the market.  Prasco ...
Cached Medicine Technology:Genprex Presenting at 10th Annual BIO Investor Forum 2Prasco® Selected as Eli Lilly and Company's Authorized Generics Partner 2
Substrate Plasma for Factor VIII Assay by STA© Analyzers. Freeze-dried human plasma from which factor VIII has been removed by selective immuno-adsorption....
Substrate Plasma for Factor XI Assay by STA© Analyzers. Freeze-dried human plasma lacking factor XI....
Enzyme Immunoassay of von Willebrand Factor Antigenby ELISA Method, 96 tests....
Colorimetric Assay of Plasminogen Activity by STA© Analyzers....
Medicine Products: