Navigation Links
New understanding of why anti-cancer therapy stops working at a specific stage
Date:6/24/2013

complex biological system.

They found that at a particular level of oxygen starvation (hypoxia) that is common in solid tumors, the mTOR signaling network switches between two sets of properties. At the switching point, the theoretical models predicted that mTOR would be intrinsically unresponsive to drugging.

Furthermore, the combined experiment and theory results indicated that the switch could be interpreted as a type of phase transition, which has not been previously observed in biological systems.

This phase transition is the point of the switch between the two signaling networks and happens very abruptly. The change in signaling means that the body of cells studied no longer responds in the way it did before. In the case of the tumor, the "drugging" of the mTOR ceases, meaning that the tumor is no longer inhibited.

These results have several implications. First, they may explain the poor clinical performance of mTOR inhibitors. Second, they indicate that certain complex biological behaviors, which often confound scientists who are seeking to find effective therapies for human diseases, may be understood by the effective application of experimental and theoretical tools derived from the physical sciences.


'/>"/>

Contact: Jerry Barach
jerryb@savion.huni.ac.il
972-258-82904
The Hebrew University of Jerusalem
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Lumositys big data provides new approach to understanding human cognition
2. Researchers gain new molecular-level understanding of the brains recovery after stroke
3. United Benefit Advisors Offers Employee Guide to Understanding PPACA
4. Biolog’s Phenotype MicroArray Technology Unlocks Critical Clue in Understanding Autism
5. Tools for better understanding breast cancer stem cells
6. OnSomble, Inc. Partners with The Aroostook Medical Center to Enhance Nurse Understanding of the Professional Role
7. Law Firm Releases New Informational Graphic on the Basics of Understanding Medical Malpractice Cases
8. Study brings greater understanding of tumor growth mechanism
9. Such a Great Date, Why Hasn't He/She Called Yet? Dr. Bonnie Provides Tips on Making it Thur the Dating Stages and Understanding the Opposite Sex
10. Sherri Gastelum and Platinum Tax Defenders Offer 5 Tips on Understanding Health Care Tax Issues from the Affordable Care Act
11. Liver disease: Understanding it will enable the provision of better treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/4/2015)... March 04, 2015 Rocket Builders’ “Ready ... Columbian companies that have the best prospect for growth ... when we choose the Ready to Rocket companies, we ... technical innovation with market opportunity. Prizm Media Inc. is ... right customers at the right time,” said Reg Nordman, ...
(Date:3/4/2015)... Jose, CA (PRWEB) March 04, 2015 ... produced by companies whose management forgot – or ignored ... potential value: Validate the market based on physician input ... seen companies – more specifically, founders – become so ... answer the key question: Will physicians use the device?” ...
(Date:3/3/2015)... March 04, 2015 MED-Ed ... design and construction event for New England, April ... announced key building envelope related workshops. Sessions offer ... Workshops include: , Curtain Walls for Labs ... health care and laboratory facilities are often required ...
(Date:3/3/2015)... Anik Singal's Profit Academy - a ... has become the talk of the town throughout ... the course's general release has garnered the attention ... to review the program's content and publish an ... keys to success with Internet marketing is having ...
(Date:3/3/2015)... 2015 NOVAtime Technology, Inc. ( ... and Attendance / Workforce Management solutions, announced that ... SaaS Workforce Management / Time and Attendance ... , Since 2004, Innovative Services’ mission has ... the best quality of life. The company is ...
Breaking Medicine News(10 mins):Health News:Healthcare Lead Generation Leader Prizm Media Inc. is “Ready to Rocket” 2Health News:Healthcare Lead Generation Leader Prizm Media Inc. is “Ready to Rocket” 3Health News:Want to Succeed in Medical Technology? Don't Innovate in a Vacuum 2Health News:Want to Succeed in Medical Technology? Don't Innovate in a Vacuum 3Health News:Building Envelope Code and Regulation Sessions at MED-Ed Facilities 2Health News:Building Envelope Code and Regulation Sessions at MED-Ed Facilities 3Health News:Building Envelope Code and Regulation Sessions at MED-Ed Facilities 4Health News:Building Envelope Code and Regulation Sessions at MED-Ed Facilities 5Health News:Building Envelope Code and Regulation Sessions at MED-Ed Facilities 6Health News:Anik Singal's Profit Academy - Review Of New IM Training Program Released 2Health News:Innovative Services, Inc. Successfully Migrates to Cloud-Based NOVAtime Workforce Management Solution to Support Growth and Improve Payroll Processing Time 2Health News:Innovative Services, Inc. Successfully Migrates to Cloud-Based NOVAtime Workforce Management Solution to Support Growth and Improve Payroll Processing Time 3
... 23 News briefs concerning,economic and business growth in ... Tampa Bay Has Right Prescription for Expansion, WellDyneRx, ... more than triple their prescription mail service,capacity with the ... expansion into Tampa Bay creates 670 new high wage ...
... DizzyFIX, an at-home treatment for vertigo and dizziness which helps guide ... , ... Calgary, Canada (PRWEB) September 23, 2008 -- The ... [treatment for vertigo] and dizziness which helps guide patients through the ...
... at retail locations,nationwide, WASHINGTON, Sept. 22 Americans ... affected by the recent,hurricanes by donating their coins at ... Simply select the Red Cross Disaster Relief Fund,or enter ... provide immediate,food, shelter, counseling and other assistance to those ...
... hakia will expand its credibility-guided,coverage beyond health and ... search engine hakia today,announced an open call to ... program to unlock credible and free Web resources ... health and medical searches to guide users towards ...
... An improved and more,accessible version of healthfinder.gov, a ... was launched today by the U.S. Department of ... and interactive health management tools make information,resources more ... "Many Americans struggle with complex health information ...
... danger , , MONDAY, Sept. 22 (HealthDay News) -- A ... people who have an underactive thyroid gland that does ... report. , As many as 27 million Americans have ... Association of Clinical Endocrinologists; about half of these people ...
Cached Medicine News:Health News:Highlights of Economic and Business Growth in the Tampa Bay Region 2Health News:Highlights of Economic and Business Growth in the Tampa Bay Region 3Health News:Highlights of Economic and Business Growth in the Tampa Bay Region 4Health News:Clearwater's Canadian at-Home Dizziness Treatment Device Cleared by FDA 2Health News:Americans Urged to Support American Red Cross Disaster Relief Efforts for Hurricanes of 2008 2Health News:hakia Issues Open Call to Librarians and Information Professionals: Help Us Guide Web Searchers to Credible Web Sites 2Health News:Improved healthfinder.gov Makes Health Information Quicker and Easier to Use 2Health News:Improved healthfinder.gov Makes Health Information Quicker and Easier to Use 3Health News:Low Thyroid Function Linked to Heart Failure Risk 2Health News:Low Thyroid Function Linked to Heart Failure Risk 3
(Date:3/3/2015)... , March 3, 2015 Frost ... recognized world-class manufacturing companies and individual leaders ... Awards. Logo - http://photos.prnewswire.com/prnh/20150303/179222LOGO ... intensifying global competition and accelerating, technology-driven change, ... themselves by embracing breakthrough innovation and enabling ...
(Date:3/3/2015)... , Mar. 03, 2015 Research and ... the addition of the "Telemedicine and Mobile ... Forecasts 2015 - 2020" report to their ... Connected Health are all terms that pertain to ... order to provide remote clinical/non-clinical healthcare services. They ...
(Date:3/3/2015)... March 3, 2015  RedHill Biopharma Ltd. ... Israeli biopharmaceutical company primarily focused on late ... gastrointestinal diseases, including gastrointestinal cancers, today announced ... Business Officer, will be presenting at VirtualInvestorConferences.com, ... Thursday, March 5, 2015, at 10:00 am ...
Breaking Medicine Technology:2015 Manufacturing Leadership Award Winners Announced 22015 Manufacturing Leadership Award Winners Announced 32015 Manufacturing Leadership Award Winners Announced 42015 Manufacturing Leadership Award Winners Announced 52015 Manufacturing Leadership Award Winners Announced 6Global Telemedicine and Mobile Healthcare Solutions, Services, and Devices: Market Analysis and Forecasts 2015 - 2020 2Global Telemedicine and Mobile Healthcare Solutions, Services, and Devices: Market Analysis and Forecasts 2015 - 2020 3RedHill Biopharma to Present at VirtualInvestorConferences.com Online Event on March 5, 2015 2RedHill Biopharma to Present at VirtualInvestorConferences.com Online Event on March 5, 2015 3RedHill Biopharma to Present at VirtualInvestorConferences.com Online Event on March 5, 2015 4
... Samsung Medison America appoints Brian Keith as Sales ... its expansive line of Ultrasound platforms. Mr. Keith will ... management in Samsung Medison America. Mr. Keith ... medical device sales experience. He has held numerous strategic ...
... PLYMOUTH MEETING, Pa., Aug. 31, 2011 BioBDx announced ... will present at the 2011 BioPharm America Conference taking ... System, a tool that objectively measures brain functions related ... FDA-cleared application of this platform technology is objective measurement ...
Cached Medicine Technology:Samsung Medison America Welcomes Brian Keith as Sales General Manager, USA 2BioBDx to Present at the 2011 BioPharm America Conference 2
... Filter Units,Filter units with hydrophobic PTFE ... membrane are ideal for the sterilizing ... sterile containers, and for sterilizing or ... mm Millex filter units are available ...
... Water, The Simplicity personal water system is ... use bottled water. In addition to the ... bottled water, your laboratory applications may be ... absorbed from containers and cause water quality ...
Designed to meet the requirements of reagent grade water for routine analysis....
... 12 L/min of Type I ultrapure water, ... Super-Q Plus System is designed to provide ... been pretreated by reverse osmosis, distillation or ... water quality which exceeds Type I ASTM/CAP/NCCLS ...
Medicine Products: