Navigation Links
New understanding of how big molecules bind will lead to better drugs, synthetic organic materials
Date:2/21/2008

ccording to the ESF workshop convenor, Professor Anthony Davis from Bristol University in the UK. But the most important aspect of the ESF workshop was the bringing together of scientists in two previously distinct fields, said Davis. Our main aim was to get two groups of scientists talking to each other - the supramolecular chemists, and a group of biologists who might be termed biomolecular engineers, said Davis. Certainly this objective was fulfilled. Supramolecular chemists study and manipulate the interactions between molecules in general, while biomolecular engineers specialise in exploiting the large organic molecules found in Nature.

Biological macromolecules include proteins comprising amino acids, complex carbohydrates made from simpler sugar molecules, as well as both RNA and DNA made from nucleic acids. Unlike small molecules, these large constructions exhibit multiple chemical properties at different parts of their surface, which means that interactions between them depend on geometrical features. It is the geometrical arrangement of the component parts, as much as their chemical identity, that determines how a macromolecule will behave and interact with other molecules both large and small. Some molecules will only react or bind with certain others, often temporarily, on a lock and key basis determined by the relative shapes of the surface. Such transient associations between large molecules (supramolecules) are very important in biology, for example in the binding between antibodies and antigens in the immune response, and also between an enzyme and its substrate, i.e. the compound it is acting upon.

These looser interactions between large molecules are called non-covalent because they do not involve sharing of electrons, but instead exploit variations in electrical charge distribution in their vicinity. Since each individual bond is weak, non-covalent bonding relies on the collective strength of multiple bonds and is therefore onl
'/>"/>

Contact: Anthony Davis
Anthony.Davis@bristol.ac.uk
44-117-954-6334
European Science Foundation
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Stem cells give clues to understanding cancer and make breakthrough in childhood leukaemia
2. Bug guts map brings scientists closer to understanding different bugs role in the body
3. Revolution in understanding of ion channel regulation
4. Understanding the have-knots: The role of stress in just about everything
5. OHSU Cancer Institute research discovery opens new window to understanding chronic myeloid leukemia
6. Understanding College Student Mental Health: The Psychological, Institutional and Legal Issues
7. Canadian Pacific and Mayo Clinic Build Understanding and Commit to Ongoing Dialogue
8. Understanding of Mammography Differs Among Races
9. Increased Understanding Called for During November National Alzheimers Disease Awareness Month by Los Angeles Jewish Homes Medical Director
10. Optical scientist honored for understanding and improving vision
11. New understanding of basic units of memory
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... cells do not divide unless there is enough oxygen ... and other cell types circumvent this rule. Researchers at ... that overrides the cells, warning signals, enabling cancers to ... In the process, the researchers found that lysosomes ... division decisions. They also uncovered new evidence that certain ...
(Date:7/28/2014)... 2014 The Brooke Jackman Foundation ... more than 200,000 books to children and families in ... of Brooke’s Cooks, a new initiative designed to promote ... among at-risk children and their families in the New ... of nutrition information workshops, cooking demonstrations and readings. BJF, ...
(Date:7/28/2014)... of two dopamine-producing regions in the brain was able ... or propofol. In the August issue of ... that rats anesthetized with continuous doses of either agent ... in response to electrical stimulation delivered to the ventral ... dopamine-releasing area, the substantia nigra, did not induce the ...
(Date:7/28/2014)... (PRWEB) July 28, 2014 Sarasota-based FCCI ... Best Companies To Work For. Still headquartered in Sarasota ... the only Florida-domiciled company in the top ten of ... Companies list appears in the August issue of Florida ... and large employer categories. Ranked #7 for 2014, FCCI ...
(Date:7/28/2014)... BEER-SHEVA, ISRAEL, July 28, 2014...Mothers who live near ... weights, according to a new study, "Green Spaces ... Occupational and Environmental Medicine . , A ... Ben-Gurion University of the Negev (BGU), evaluated nearly ... cohort in Tel Aviv, Israel to determine the ...
Breaking Medicine News(10 mins):Health News:Cell's recycling center implicated in division decisions 2Health News:Brooke Jackman Foundation Launches Brooke's Cooks, New Initiative to Promote Healthy Living Among At-Risk Youth and Their Families 2Health News:Brooke Jackman Foundation Launches Brooke's Cooks, New Initiative to Promote Healthy Living Among At-Risk Youth and Their Families 3Health News:Brooke Jackman Foundation Launches Brooke's Cooks, New Initiative to Promote Healthy Living Among At-Risk Youth and Their Families 4Health News:Stimulation of brain region restores consciousness to animals under general anesthesia 2Health News:FCCI Insurance Group Makes Top 100 Best Companies List – and is the Only Florida-Headquartered Company in Top Ten 2Health News:FCCI Insurance Group Makes Top 100 Best Companies List – and is the Only Florida-Headquartered Company in Top Ten 3
... 25 The Akron General Health System, a,nationally ... and,wellness, is accepting nominations for its second annual ... individuals and,corporations/organization -- throughout the State of Ohio ... or the health of their,employees., Nominations for ...
... know that there,s a new infant formula that blocks ... Vitamin D status during pregnancy will affect her baby,s ... syrup that prevents early-childhood tooth decay? ,These are but ... which will be presented when the International,Association for Dental ...
... Viral video communicates the importance of skin cancer ... Neutrogena(R) Partnership for,Skin Health, a public service initiative ... advancements and explore solutions for,skin health, has tapped ... video about self-examination for skin cancer detection. As ...
... National Association of Health Care Assistants Delivers Letter ... to Seniors, Nursing Home,Care, JOPLIN, Mo., June ... (NAHCA) -- representing the voice of,more than 20,000 ... 29 states and,the District of Columbia -- delivered ...
... in German . , Oregano doesnt only ... and the ETH Zrich have discovered that this spice also ... cure inflammations. The researchers administered its active ingredient known ... seven out of ten cases there was a subsequent improvement ...
... is a national concern that led the U.S. surgeon ... and Reduce Underage Drinking" ( http://www.surgeongeneral.gov/topics/underagedrinking/ ) last year. ... researcher assesses the effectiveness of underage drinking prevention programs ... key goals outlined by the surgeon general. , Lead ...
Cached Medicine News:Health News:Statewide Wellness Awards Competition Now Open for Nominations 2Health News:International Dental Research Association meets in Toronto 2Health News:International Dental Research Association meets in Toronto 3Health News:International Dental Research Association meets in Toronto 4Health News:Neutrogena(R) Partnership For Skin Health Taps Malin Akerman to Educate About Skin Cancer Detection 2Health News:Neutrogena(R) Partnership For Skin Health Taps Malin Akerman to Educate About Skin Cancer Detection 3Health News:Nation's Health Care and Nursing Assistants Urge HHS to Withdraw Proposed $770 Million Funding Cut to Skilled Nursing Care 2Health News:Salutary pizza spice 2Health News:Pediatrics review of underage drinking prevention programs led by Iowa State researcher 2Health News:Pediatrics review of underage drinking prevention programs led by Iowa State researcher 3
(Date:7/28/2014)... 28, 2014  Some 2,500 scientists and experts from ... Montreal for the largest international meeting ... that draws researchers from fields as far flung as ... as designing new manufacturing processes to creating life-saving drugs. ... because the United Nations has declared 2014 the International ...
(Date:7/28/2014)... 2014  Surgical Theater, LLC announced today the ... Advisory Board. New members include Ori J. ... Development and New Technologies for Given Imaging Ltd., ... Vice President and General Manager of Philips Healthcare,s ... simulation technology to brain surgery and has developed ...
(Date:7/28/2014)... 28, 2014  Air Products (NYSE: APD ... oxygen is vital to any healthcare facility. This understanding ... only improve the efficiency of its oxygen supply systems, ... these systems—including systems for emergency oxygen supply ... 4-5 at the 51 st ASHE Annual ...
Breaking Medicine Technology:All About Crystals: Tiny, Giant, from Mars, from Earth's Mantle, in Medicine and in Manufacturing 2All About Crystals: Tiny, Giant, from Mars, from Earth's Mantle, in Medicine and in Manufacturing 3All About Crystals: Tiny, Giant, from Mars, from Earth's Mantle, in Medicine and in Manufacturing 4All About Crystals: Tiny, Giant, from Mars, from Earth's Mantle, in Medicine and in Manufacturing 5All About Crystals: Tiny, Giant, from Mars, from Earth's Mantle, in Medicine and in Manufacturing 6Surgical Theater Names Former Given Imaging Ltd. and Philips Healthcare Executives to Business Advisory Board 2Surgical Theater Names Former Given Imaging Ltd. and Philips Healthcare Executives to Business Advisory Board 3Surgical Theater Names Former Given Imaging Ltd. and Philips Healthcare Executives to Business Advisory Board 4Surgical Theater Names Former Given Imaging Ltd. and Philips Healthcare Executives to Business Advisory Board 5Air Products Highlights Its Medical Oxygen Supply Systems for Emergency Oxygen Supply and Reduced Oxygen Loss at ASHE 2Air Products Highlights Its Medical Oxygen Supply Systems for Emergency Oxygen Supply and Reduced Oxygen Loss at ASHE 3
... event today on Capitol Hill, the Global Fund ... of the Global Fight Against AIDS, Tuberculosis and ... the Global Fund,s lifesaving work. From assistance in ... consumer markets, to in-country partnerships, Chevron, The Coca-Cola ...
... 20, 2012 The March of Dimes announced today that ... 2012 March for Babies, the March of Dimes number one ... the Prematurity Campaign.  Together, the organizations will also work to ... "Watson employees are participating in March for Babies events ...
Cached Medicine Technology:Global Fund Celebrates Efforts of Partners Chevron, The Coca-Cola Company, (RED) and PEPFAR at Capitol Hill Event 2Global Fund Celebrates Efforts of Partners Chevron, The Coca-Cola Company, (RED) and PEPFAR at Capitol Hill Event 3Global Fund Celebrates Efforts of Partners Chevron, The Coca-Cola Company, (RED) and PEPFAR at Capitol Hill Event 4Watson Partners With March of Dimes to Help Fight Preterm Birth 2
... Diagnostics is a leading provider of immunofluorescence ... test menu that includes kits for autoimmune ... as miscellaneous conjugates and components. Our Impact ... assortment of substrates and kit sizes to ...
... Professional Diagnostics is a leading provider of ... DFA test menu that includes kits for ... well as miscellaneous conjugates and components. Our ... wide assortment of substrates and kit sizes ...
... Inverness Medical Professional Diagnostics is a leading ... IFA and DFA test menu that includes ... STDs as well as miscellaneous conjugates and ... you a wide assortment of substrates and ...
... infectious disease ELISA products make us a ... protocols for faster integration into the busy ... increased reliability and run-to-run consistency. Our Infectious ... for a wide range of serological assays ...
Medicine Products: