Navigation Links
New understanding can lead to srategies for dealing with neurodegenerative diseases
Date:12/6/2012

Jerusalem Dec. 6, 2012 A new understanding of what takes place on the cellular level during the development of neurodegenerative diseases, such as Parkinson's, Alzheimer's, ALS and Huntington's diseases, offers promise towards possible new strategies for combating such diseases, say Hebrew University of Jerusalem researchers.

Neurodegenerative conditions result from an impairment of motor function or cognitive function or both. This impairment results from degeneration in the particular area of the brain responsible for those functions.

Although these neurodegenerative diseases have been functionally linked to toxic protein aggregation (deposits), there is much that is unknown about the mechanism through which aggregation causes toxicity and death at the cellular level. Inclusion bodies structures comprised of pathogenic protein aggregates -- have long been seen as a hallmark of disease, but the relationship between inclusions and disease has remained somewhat mysterious.

In a study published in PNAS (Proceedings of the National Academy of Sciences in the US). Hebrew University researchers (working in the lab of Dr. Daniel Kaganovich in the Cell and Developmental Biology Department, together with collaborators) present evidence that suggests that these inclusion bodies, which have traditionally been thought to accompany disease onset, actually have a cell-biological function that is not necessarily related to the disease conditions.

Further, the researchers suggest that some of those inclusion bodies not only are not toxic, but actually are part of a natural protective process. The researchers have identified two inclusion bodies, which they call JUNQ and IPOD. Aggregation in the JUNQ can lead to toxicity, whereas aggregation in the IPOD is protective.

These findings, say the Hebrew University researchers, point up a new potential strategy for designing therapeutics for neurodegenerative disease. Instead of preventing proteins from aggregating, which can be very difficult, it may be possible to enhance the cellular ability to actively enclose harmful aggregates within protective inclusions, thereby neutralizing the toxic proteins that bring on further neurodegenerative damage and even death.


'/>"/>
Contact: Jerry Barach
jerryb@savion.huji.ac.il
972-258-82904
The Hebrew University of Jerusalem
Source:Eurekalert  

Related medicine news :

1. After 100 years, understanding the electrical role of dendritic spines
2. Research reveals new understanding of X chromosome inactivation
3. Understanding antibiotic resistance using crystallography and computation
4. Advancing understanding of treatment through clinical trials
5. Researchers closer to understanding actions of cells involved in atherosclerosis
6. Studies seek better understanding and treatment of depression
7. Wayne State develops better understanding of memory retrieval between children and adults
8. Understanding flirtation in negotiation, shooter bias, love during marriage, and more
9. Discovery improves understanding of early onset inflammatory disease
10. Cedars-Sinai researchers, with stem cells, advance understanding of spinal muscular atrophy
11. Understanding the links between inflammation and chronic disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New understanding can lead to srategies for dealing with neurodegenerative diseases
(Date:6/25/2016)... City, Oklahoma (PRWEB) , ... June 25, 2016 ... ... helping both athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic ... the Oklahoma City area —Johnson is one of the first doctors to perform ...
(Date:6/24/2016)... ... 2016 , ... A recent article published June 14 on E ... goes on to state that individuals are now more comfortable seeking to undergo not ... as calf and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians ...
(Date:6/24/2016)... ... ... Marcy was in a crisis. Her son James, eight, was out of control. Prone to ... , “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If there ... my other children and say he was going to kill them. If we were ...
(Date:6/24/2016)... ... 24, 2016 , ... Dr. Amanda Cheng, an orthodontist ... has extensive experience with all areas of orthodontics, including robotic Suresmile technology, ... , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It can be used ...
(Date:6/24/2016)... , ... June 24, 2016 , ... People across the ... Genome magazine’s Code Talker Award, an essay contest in which patients and their families ... to be presented at the 2016 National Society of Genetic Counselors (NSGC) Annual Education ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... Story Highlights: ... the health care industry is causing providers to review ... Deloitte offers a suite of solutions for health care ... cost optimization: labor resource analysis, revenue cycle optimization and ... outcomes and better economics ...
(Date:6/24/2016)... Calif. , June 24, 2016  Global ... a biopharmaceutical company developing novel therapeutics for the ... needs, today announced the closing of its previously ... common stock, at the public offering price of ... the offering were offered by GBT. GBT estimates ...
(Date:6/24/2016)... , June 24, 2016 ... the "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" ... In-Mold Electronics, Smart Skin, Structural ... Structural electronics involves electronic and/or ... protective structures, replacing dumb structures such as vehicle ...
Breaking Medicine Technology: