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New type of adult stem cells found in the prostate may be involved in prostate cancer development
Date:9/9/2009

e cancer."

And indeed, the researchers found that CARNs in mice can give rise to prostate cancers, after the cells lose the activity of PTEN, a gene that is frequently mutated in human prostate cancers.

The results do not mean, however, that CARNs give rise to "cancer stem cells," cells inside a tumor that are capable of regenerating the cancer from a single cell. "The relationship between the normal prostate stem cells and potential cancer stem cells is not known yet," said Dr. Shen. "And even the existence of cancer stem cells in prostate tumors is not established."

Also unclear is whether CARNs exist in the normal human prostate and if human prostate cancers originate from these CARNs. Dr. Shen's lab is now looking to investigate these issues.


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Contact: Elizabeth Streich
eas2125@columbia.edu
212-305-6535
Columbia University Medical Center
Source:Eurekalert

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