Navigation Links
New type of adult stem cells found in the prostate may be involved in prostate cancer development
Date:9/9/2009

NEW YORK A new type of stem cell discovered in the prostate of adult mice can be a source of prostate cancer, according to a new study by researchers at the Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center and NewYork-Presbyterian Hospital.

Led by Michael Shen, Ph.D., professor of medicine and genetics and development at Columbia University Medical Center, the researchers found the rare stem cells, called CARNs (which stands for "castration-resistant Nkx3.1-expressing cells"), within the ducts inside the mouse prostate. The stem cells are involved in regenerating prostate tissue, but the researchers also found that CARNs can give rise to cancer if certain tumor suppressor genes in the cells are inactivated.

The findings will be published in an advance online edition of Nature at 1 p.m. ET on Wednesday, September 9, 2009.

Understanding which cells in the prostate give rise to cancer may help researchers develop better treatments for prostate cancer. But the identity of these cells of origin for prostate cancer has been controversial.

Recently, some researchers have proposed that prostate cancer may arise from normal adult stem cells, since stem and cancer cells share several characteristics. But the only stem cells previously described in the prostate are basal cells, which have been considered to form a "support" layer for the luminal cells that make prostate secretions. However, since prostate cancers are filled exclusively with cells that have features of luminal cells, it has been unclear how cancer might arise from basal cells.

The new study may resolve this conundrum because the newly discovered adult stem cells are also luminal cells. "Previous research suggested that prostate cancer originates from basal stem cells, and that during cancer formation these cells differentiate into luminal cells," said Dr. Shen. "Instead, CARNs may represent a luminal origin for prostate cancer."

And indeed, the researchers found that CARNs in mice can give rise to prostate cancers, after the cells lose the activity of PTEN, a gene that is frequently mutated in human prostate cancers.

The results do not mean, however, that CARNs give rise to "cancer stem cells," cells inside a tumor that are capable of regenerating the cancer from a single cell. "The relationship between the normal prostate stem cells and potential cancer stem cells is not known yet," said Dr. Shen. "And even the existence of cancer stem cells in prostate tumors is not established."

Also unclear is whether CARNs exist in the normal human prostate and if human prostate cancers originate from these CARNs. Dr. Shen's lab is now looking to investigate these issues.


'/>"/>

Contact: Elizabeth Streich
eas2125@columbia.edu
212-305-6535
Columbia University Medical Center
Source:Eurekalert

Related medicine news :

1. PRC Launches New Web Resource for Teaching Language to Children & Adults with Speech Disabilities
2. Healthcare Reform Could Raise Premiums for Young Adults
3. Adult Weight Gain Tied to Prostate Cancer Risk
4. Researchers Make Insulin-Producing Cells From Adult Skin Cells
5. Seven Secrets to Successful Caregiving of Older Adults
6. CVS Caremark Data Finds More than 50 Percent of Adults 45-years and Younger are not Adherent to Cholesterol Lowering Medications
7. Just in Time for Allergy Season, ZYRTEC(R) Provides New Solutions for Adults and Children
8. Preemie Birth Could Mean Weaker Bones as Adults
9. Long-term exercise, healthy eating habits in young adults: U-M study
10. Celling Technologies Sets New Standards With Sophisticated Adult Stem Cell Device
11. Video: Sounds of Pertussis Campaign Urges Adults to Take Action During National Immunization Awareness Month
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... ... 23, 2017 , ... "The Better Care Reconciliation Act (BCRA) ... to people with all chronic conditions, including mental illnesses, while increasing the cost ... Affordable Care Act (ACA) requirement that insurers cover pre-existing conditions, it does not ...
(Date:6/23/2017)... ... June 23, 2017 , ... ... practicing in Newburgh, New York, has recently begun offering three new minimally invasive ... the best cutting-edge procedures and reducing downtime, Dr. Rubinstein is excited to bring ...
(Date:6/23/2017)... ... June 23, 2017 , ... ... and two new videos highlight the importance of correctly using a meat thermometer. ... who has done extensive research on consumer food safety habits. Dr. Bruhn explains ...
(Date:6/23/2017)... ... June 23, 2017 , ... ... Insurance offerings. With the Federal Emergency Management Agency’s (FEMA) recent update of flood ... States. In 2012, the Biggert-Waters Act was enacted to reflect the actual risk ...
(Date:6/23/2017)... ... June 23, 2017 , ... All-Star Insurance, a family managed agency that ... eastern Texas, is announcing the launch of a new charity drive to benefit women ... the United States reveal that an estimated 252, 710 new cases of invasive or ...
Breaking Medicine News(10 mins):
(Date:5/30/2017)... DarioHealth Corp. (NASDAQ: DRIO), a leading global digital health ... it will be presenting at the 7th annual LD Micro Invitational ... Raphael , CEO, of DarioHealth will be giving the presentation and ... June 6th & 7th, 2017 at the Luxe Sunset Bel Air ... space. About LD Micro LD ...
(Date:5/30/2017)... 2017 Therapix Biosciences Ltd. (Nasdaq: TRPX), ... the development of cannabinoid-based drugs, today announced that ... at three upcoming scientific and investor conferences in ... Invitational: ...                     Wednesday, June ...
(Date:5/26/2017)... -- Endo International plc (NASDAQ: ENDP ) announced today ... the Company in a fireside chat at Goldman Sachs, 38 ... 2017 at 10:40 a.m. PT / 1:40 p.m. ET. The ... Rancho Palos Verdes, CA. A live ... on the Company,s website at http://www.endo.com/investors/overview . Participants should ...
Breaking Medicine Technology: