Navigation Links
New twist on potential malaria drug target acts by trapping parasites in cells
Date:5/14/2010

>

The method, first developed in a mammalian cell culture system by co-author Thomas Wandless of Stanford University, allows scientists to analyze the function of certain proteins and to identify other potential therapeutic targets in the malaria parasite, the researchers said.

As adapted for this study, Dvorin and his colleagues reverse-engineered candidate genes to make faulty proteins that would only survive in the presence of a stabilizing chemical. Without that constant protection, the protein is eliminated from the parasite.

"For 24 hours a day, 7 days a week, we grew the parasites in the presence of the stabilizing chemical," Dvorin said. "After the parasites invaded new red blood cells, we washed away the stabilizing drug. Even though the parasites seemed to develop just fine, they were unable to leave the red blood cell."

Interestingly, the team's work also produced an elusive scientific tool for their colleagues in the vaccine field: Mature invasive parasites. "One of the experiments in the paper mechanically releases the parasites, which have matured into virulent and invasive forms," Duraisingh said. "People have been trying to get viable parasites in this form for study. This is a great resource for vaccine studies."


'/>"/>

Contact: Christina Roache
croache@hsph.harvard.edu
617-384-8979
Harvard School of Public Health
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. A New Twist On Convert to Purchase
2. Latest Twist: Ousted Union Officials Show True Colors By Trying to Stop 29 Union Elections
3. Potential new twist in breast cancer detection
4. A century-old puzzle comes together: Scientists ID potential protein trigger in lung disease sarcoidosis
5. MVP Health Care Eliminates Potential Health Insurance Coverage Gap for Many Young Adults
6. Test Spots Potential Organ Donors Among Coma Patients
7. Potentially Lethal Airborne Fungus May Spread to California
8. MU researchers show potential for new cancer detection and therapy method
9. IMPACT results show potential cancer treatment
10. BATTLE links potential biomarkers to drugs for lung cancer
11. New phase II study supports potential of gs-9450 as new treatment option for steatohepatitis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... Best Cheap Hosting USA is among the most distinguished ... announced that iPower ( http://www.best-cheap-hosting-usa.com/go/iPower/ ) is the best ... world. , “iPower is one of the most reliable ... kinds of useful products for new and old clients. ... service and a number of features which will appeal ...
(Date:10/22/2014)... CA (PRWEB) October 22, 2014 Lintelus, ... Cormier, Sr. Vice President of Sales, will be speaking ... upcoming Meetings Technology Expo on October 28, at the ... be hosting a booth as well as a Tech ... Lintelus Meeting can create a more engaging event experience. ...
(Date:10/22/2014)... Maureen Salamon HealthDay ... Black women undergoing in vitro fertilization (IVF) are only about ... the popular assisted reproduction technique, new research indicates, and the ... In the study, about 31 percent of white patients became ... patients. Analyzing more than 4,000 IVF cycles over two ...
(Date:10/22/2014)... Oct. 21, 2014 (HealthDay News) -- Measures taken by ... in Ebola-ravaged Liberia may have limited the spread of ... report. The Firestone Natural Rubber Co. provides health ... residents of nearby densely populated communities. Between Aug. ... suspected Ebola cases among those 80,000 people. That incidence ...
(Date:10/20/2014)... 20, 2014 With a mere 19 ... Crist made a brief fundraising stop at the ... , Fresh from a debate last night with his ... stage for the first seven minutes because Crist had ... described the incident in one word: "weird." , Before ...
Breaking Medicine News(10 mins):Health News:Best Cheap Hosting USA Has Recently Announced The Best Cheap Web Hosting Companies In 2014 2Health News:Jay Cormier, Sr. Vice President of Sales for Lintelus, Speaks about Event Technology Integration at Meetings Technology Expo in NYC 2Health News:Black Women Fare Worse With Fertility Treatments, Study Says 2Health News:Black Women Fare Worse With Fertility Treatments, Study Says 3Health News:Tire Company Sets Standard for Ebola Care in Liberia: CDC 2Health News:At Crist Fundraiser, Dan Newlin Says, "No More Robert Germans," Will Seek Changes to Florida Missing Persons Law 2Health News:At Crist Fundraiser, Dan Newlin Says, "No More Robert Germans," Will Seek Changes to Florida Missing Persons Law 3
... family members and celebrities about their own struggles , THURSDAY, ... more than a third of Americans polled believe that the ... change largely to openness by friends, family members and public ... of those polled said that such openness on the part ...
... ... recovery , ... (PRWEB) May 6, 2010 -- PHD Virtual Technologies , pioneer and innovator in backup ... The new backup and recovery solution is purpose-built for the growing number of virtualized XenServer ...
... the largest medical research grants ever awarded to the ... and administrators. The National Institutes of Health grant will ... as high blood pressure, diabetes and stroke. The conditions ... leading cause of death in Missouri and the nation. ...
... summer weight-loss camp markedly improved obese children,s health, a ... reports. A Saint Louis University physician found the ... fitness and blood pressure. "Weight loss is like ... to be successful," said Nadim Kanafani, M.D., corresponding author ...
... renowned faculty of clinicians and researchers who will present ... managing the full spectrum of prostate cancer and related ... patients/spouses, caregivers and advocates as well as physicians and ... Luncheon Speaker--Clifton Leaf, award-winning author and business journalist ...
... the brain, research suggests , THURSDAY, May 6 (HealthDay News) ... is wandering, a new study suggests. , Canadian researchers asked ... a computer. As they read the passage, a sensor tracked ... they had been paying attention to what they were reading ...
Cached Medicine News:Health News:PHD Virtual Technologies Meets the Need for Fully Integrated Data Protection with PHD Virtual Backup for Citrix XenServer 2Health News:PHD Virtual Technologies Meets the Need for Fully Integrated Data Protection with PHD Virtual Backup for Citrix XenServer 3Health News:PHD Virtual Technologies Meets the Need for Fully Integrated Data Protection with PHD Virtual Backup for Citrix XenServer 4Health News:MU awarded $8.5 million to explore tiny vessels' role in cardiovascular diseases 2Health News:MU awarded $8.5 million to explore tiny vessels' role in cardiovascular diseases 3Health News:The biggest winners: Summer campers 2Health News:Rutgers and the Prostate Net host prostate cancer symposium, May 15 2
(Date:10/22/2014)...   Surefire Medical , Inc., the developer of ... targeted delivery of embolization agents in minimally invasive direct-to-tumor ... John R. Daniels , MD of the University of ... Steven C. Katz , MD of the Roger ... Board (SAB).    "The role of the ...
(Date:10/22/2014)... , Oct. 22, 2014 Sanomedics International ... 2014 report by Global Research & Data Services, demand ... year from 2014 through 2018, as demand for more ... is the world,s largest market for thermometers, ... advanced thermometers is Sanomedics International Holdings, Inc. ...
(Date:10/22/2014)... and AUSTIN, Texas , ... PureMHC LLC today announced they have entered into ... antibody-based immunotherapies designed to target cancers. ... peptides displayed on the surfaces of tumor cells ... targets (PTTs), derived from proteins that play a ...
Breaking Medicine Technology:Surefire Medical's Scientific Advisory Board Expands, Broadens Clinical Trial Expertise 2Sanomedics International Holdings Analyst Report: Taking Some Heat by BrokerBank Securities, Inc. 2Biotech Companies To Co-Discover And Co-Develop Antibodies Targeting Novel Phosphopeptide Tumor Targets 2
... , ... Food and Drug Administration (FDA) has notified health professionals, and ... -- from the use of negative pressure wound therapy (NPWT). ... therapy devices can help in the healing and closure of ...
... , ... a leading provider of software solutions to optimize clinical ... release of StudyOptimizer 4, the latest iteration of its ... pharmaceutical companies, DecisionView,s flagship product now includes advanced historical ...
Cached Medicine Technology:Negative Pressure Wound Devices Draw FDA Notice, Advice 2DecisionView Launches StudyOptimizer(TM) 4 2DecisionView Launches StudyOptimizer(TM) 4 3
... management software - was designed by ... improvement tool helps diabetes care providers ... bridges medicine with technology by providing ... information technology product. This diabetes ...
... management of diabetes in order to maintain tight ... effective way to reduce or even prevent diabetes-related ... improving a diabetes patients quality of life, however, ... have been the guiding factors in the development ...
... by the CGMS System Gold can assist ... program based on detailed glycemic profiles. Its ... improve motivation and collaboration with patients.1, ... with all diabetes patients, it may be ...
... Biographer is intended for detecting trends and ... (aged 18 and older) and children/adolescents (aged ... supervise the use of the G2 Biographer ... intended to supplement, not replace, conventional blood ...
Medicine Products: