Navigation Links
New twist on potential malaria drug target acts by trapping parasites in cells
Date:5/14/2010

Boston, MA -- Harvard School of Public Health (HSPH) researchers and colleagues seeking to block invasion of healthy red blood cells by malaria parasites have instead succeeded in locking the parasites within infected blood cells, potentially containing the disease.

The findings reveal an essential step in the biology of the most common and severe malaria parasite, Plasmodium falciparum, and offer a new drug target for fighting one of the world's most common and dangerous infections.

Malaria sickens up to one half billion people every year and kills up to one million, mostly children in sub-Saharan Africa. The high fevers, shaking chills, flu-like symptoms, and anemia can be fatal unless treated quickly. Malaria has grown resistant to a long list of drugs, and vaccines are still in experimental stages.

Working with the malaria parasite and human blood in test tubes and lab dishes, the research team identified a single fast-acting protein in the parasite that enables it and several dozen of its offspring to escape from a human red blood cell in preparation for quick invasion of many more healthy blood cells. Eliminating that protein traps the parasites in the cell.

After an infected mosquito bites a person, malaria parasites move into the liver, where they silently mature and multiply within weeks. Malaria parasites make people sick weeks or months later when they enter red blood cells and begin an exponential expansion. In a single cell, a parasite produces up to 32 offspring in about two days, which burst out to infect more red blood cells.

"This is the stage where things have to happen very fast for the parasite," said senior author Manoj Duraisingh, HSPH assistant professor of immunology and infectious diseases and senior author of the paper in the May 14 Science. "The parasite doesn't like to spend much time outside the cell. It grows and matures, and immediately following rupture, enters a new cell
'/>"/>

Contact: Christina Roache
croache@hsph.harvard.edu
617-384-8979
Harvard School of Public Health
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. A New Twist On Convert to Purchase
2. Latest Twist: Ousted Union Officials Show True Colors By Trying to Stop 29 Union Elections
3. Potential new twist in breast cancer detection
4. A century-old puzzle comes together: Scientists ID potential protein trigger in lung disease sarcoidosis
5. MVP Health Care Eliminates Potential Health Insurance Coverage Gap for Many Young Adults
6. Test Spots Potential Organ Donors Among Coma Patients
7. Potentially Lethal Airborne Fungus May Spread to California
8. MU researchers show potential for new cancer detection and therapy method
9. IMPACT results show potential cancer treatment
10. BATTLE links potential biomarkers to drugs for lung cancer
11. New phase II study supports potential of gs-9450 as new treatment option for steatohepatitis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... More states are passing legislation permitting or requiring schools ... child having a severe allergic reaction. Epinephrine auto-injectors ... that can lead to throat swelling, breathing difficulties, a ... In people with severe allergies to certain foods, ... certain drugs, anaphylaxis can occur within moments of exposure ...
(Date:9/19/2014)... Wisconsin (MCW) scientists has identified a new gene associated with ... humans. The findings are published in the September issue of ... Ph.D., associate professor of pediatrics at MCW and a researcher ... study and is the corresponding author of the paper. , ... in which a variant was associated with fasting glucose levels ...
(Date:9/19/2014)... September 19, 2014 BCC Research reveals ... AND GLOBAL MARKETS , the global market for human ... billion by 2018, with a five-year compound annual growth ... is growing at a steady 3.8% CAGR. , Given ... lower sales, coupled with the incidence of increasing mortality ...
(Date:9/19/2014)... NY (PRWEB) September 19, 2014 Ticket ... presale tickets for her 2015 “Honeymoon” Tour. This ... ARIANA-2015 for additional savings at the checkout. , Ariana Grande ... MO (Independence Event Center) , Feb. 28, 2015: Milwaukee, WI ... MN (Xcel Energy Center) , March 03, 2015: Chicago, IL ...
(Date:9/19/2014)... from the wonder material graphene has been used to ... cancer. , The biosensor has been shown to ... tests currently in use, and was able to provide ... possibility of a rapid, point-of-care diagnostic tool for patients. ... in IOP Publishing,s journal 2D Materials . , ...
Breaking Medicine News(10 mins):Health News:More Schools Stocking Shots That Counter Serious Allergic Reactions 2Health News:More Schools Stocking Shots That Counter Serious Allergic Reactions 3Health News:Global Market for Human Antifungal Therapeutics to Reach Nearly $13.9 Billion in 2018; Over-The-Counter (OTC) Segment Growing At 3.8% CAGR 2Health News:Global Market for Human Antifungal Therapeutics to Reach Nearly $13.9 Billion in 2018; Over-The-Counter (OTC) Segment Growing At 3.8% CAGR 3Health News:Ariana Grande Tickets in Miami, Philadelphia, Chicago, Saint Paul, Fairfax, Uncasville, Orlando, San Jose, New York, Detroit, San Antonio, Pittsburgh, Atlanta & Dallas 2Health News:Ariana Grande Tickets in Miami, Philadelphia, Chicago, Saint Paul, Fairfax, Uncasville, Orlando, San Jose, New York, Detroit, San Antonio, Pittsburgh, Atlanta & Dallas 3Health News:Ariana Grande Tickets in Miami, Philadelphia, Chicago, Saint Paul, Fairfax, Uncasville, Orlando, San Jose, New York, Detroit, San Antonio, Pittsburgh, Atlanta & Dallas 4Health News:Graphene sensor tracks down cancer biomarkers 2
... and public campaigner, has made known the fact that she ... , Dame Anita known worldwide for her company, ... was infected with the virus in 1971 via infected blood, ... businesswoman who is well known for her indefatigable campaigning has ...
... Organization (PAHO) are working with health authorities in Paraguay ... has affected a// number of communities throughout the nation ... America. ,PAHO officials warn that the entire ... prepare for what promises to be a "difficult year" ...
... A recent study by scientists at University of Wisconsin-Madison ... hear better. ,Led by Ruth Litovsky, an ... suggests that deaf children who have a cochlear implant ... use both implants instead of one. Children with two ...
... treatment for an abdominal aortic aneurysm, a weak spot ... time. If the vessel ruptures suddenly before surgery to ... scientists say they have identified a key enzyme that ... growth of aneurysms. Their finding raises hopes for developing ...
... omega-3 fatty acids on their own can alleviate depression, ... there is only limited evidence that they can relieve ... adds. ,Evidence from circumstantial research has suggested ... such as depression. And the findings have attracted widespread ...
... bottle-fed children, reveals a large, long term study, published// ahead ... ,Over 3000 children from 16 rural and urban areas ... of the Boyd Orr Study of Diet and Health in ... on 1414 people in their 60s and 70s, for whom ...
Cached Medicine News:Health News:Body Shop Founder’s New Project-against Hepatitis 2Health News:PAHO Urges Readiness for Dengue Outbreaks in 2007 2Health News:Cochlear Implants in Both Ears Enables Better Hearing 2Health News:Cochlear Implants in Both Ears Enables Better Hearing 3Health News:Enzyme Critical for Early Growth of Abdominal Aortic Aneurysms 2Health News:Enzyme Critical for Early Growth of Abdominal Aortic Aneurysms 3
(Date:9/19/2014)... Intarcia Therapeutics, Inc. today announced the presentation ... ITCA 650 (continuous subcutaneous delivery of exenatide) in type ... the 50 th Annual Meeting of the European ... the open-label, phase 3 FREEDOM-HBL (high baseline) trial showed ... poorly controlled type 2 diabetes. The results were presented ...
(Date:9/18/2014)... , September 19, 2014 ... Markets ( http://www.researchandmarkets.com/research/qqjrnh/global_molecular ) has announced the ... Market 2014-2018" report to their offering. ... Cytogenetics involves the study of chromosomes using ... functions of genes and chromosomes. It plays ...
(Date:9/18/2014)... -- PRO-DEX, INC. (NasdaqCM: PDEX) today announced financial results for ... 30, 2014. Quarter Ended June 30, ... 2014 increased $492,000, or 18%, to $3.2 million from ... 2013, due primarily to an increase of $746,000 in ... largest customer, partially offset by an aggregate decrease in ...
Breaking Medicine Technology:Intarcia Announces Presentation of Phase 3 Data at EASD Showing ITCA 650 Markedly Reduces Blood Sugar In Patients With Poorly Controlled Type 2 Diabetes 2Intarcia Announces Presentation of Phase 3 Data at EASD Showing ITCA 650 Markedly Reduces Blood Sugar In Patients With Poorly Controlled Type 2 Diabetes 3Intarcia Announces Presentation of Phase 3 Data at EASD Showing ITCA 650 Markedly Reduces Blood Sugar In Patients With Poorly Controlled Type 2 Diabetes 4Global Molecular Cytogenetics Market 2014-2018: Key Vendors are Abbott, Affymetrix, Agilent Technologies, F. Hoffmann-La Roche, Illumina and PerkinElmer 2Global Molecular Cytogenetics Market 2014-2018: Key Vendors are Abbott, Affymetrix, Agilent Technologies, F. Hoffmann-La Roche, Illumina and PerkinElmer 3Pro-Dex, Inc. Announces Fiscal 2014 Fourth Quarter And Full-Year Results 2Pro-Dex, Inc. Announces Fiscal 2014 Fourth Quarter And Full-Year Results 3Pro-Dex, Inc. Announces Fiscal 2014 Fourth Quarter And Full-Year Results 4Pro-Dex, Inc. Announces Fiscal 2014 Fourth Quarter And Full-Year Results 5Pro-Dex, Inc. Announces Fiscal 2014 Fourth Quarter And Full-Year Results 6Pro-Dex, Inc. Announces Fiscal 2014 Fourth Quarter And Full-Year Results 7Pro-Dex, Inc. Announces Fiscal 2014 Fourth Quarter And Full-Year Results 8Pro-Dex, Inc. Announces Fiscal 2014 Fourth Quarter And Full-Year Results 9Pro-Dex, Inc. Announces Fiscal 2014 Fourth Quarter And Full-Year Results 10Pro-Dex, Inc. Announces Fiscal 2014 Fourth Quarter And Full-Year Results 11Pro-Dex, Inc. Announces Fiscal 2014 Fourth Quarter And Full-Year Results 12Pro-Dex, Inc. Announces Fiscal 2014 Fourth Quarter And Full-Year Results 13
... Carnegie Mellon University,s Bone Tissue Engineering Center ... limbs in combat. (Logo: http://photos.prnewswire.com/prnh/20020422/CMULOGO) ... Hollinger, director of the center, and Professor Krzysztof ... Department of Defense research grant to develop a ...
... Stanley M. Chesley of the Cincinnati, Ohio-based law firm of ... a major class action lawsuit against DePuy Orthopaedics, Inc. and ... Johnson and Johnson recently recalled over 90,000 ASR XL Acetabular ... causing patients to undergo hip replacement surgery. ...
Cached Medicine Technology:CMU's Bone Tissue Engineering Center Receives Defense Department Research Grant to Help Injured Soldiers 2
Reusable, stainless steel trephine with handle....
Reusable, stainless steel trephine with handle....
Each handle is designed to fit a specific trephine size. For use in performing free-hand uniform donor buttons....
Each handle is designed to fit a specific trephine size. For use in performing free-hand uniform donor buttons....
Medicine Products: