Navigation Links
New twist on potential malaria drug target acts by trapping parasites in cells
Date:5/14/2010

Boston, MA -- Harvard School of Public Health (HSPH) researchers and colleagues seeking to block invasion of healthy red blood cells by malaria parasites have instead succeeded in locking the parasites within infected blood cells, potentially containing the disease.

The findings reveal an essential step in the biology of the most common and severe malaria parasite, Plasmodium falciparum, and offer a new drug target for fighting one of the world's most common and dangerous infections.

Malaria sickens up to one half billion people every year and kills up to one million, mostly children in sub-Saharan Africa. The high fevers, shaking chills, flu-like symptoms, and anemia can be fatal unless treated quickly. Malaria has grown resistant to a long list of drugs, and vaccines are still in experimental stages.

Working with the malaria parasite and human blood in test tubes and lab dishes, the research team identified a single fast-acting protein in the parasite that enables it and several dozen of its offspring to escape from a human red blood cell in preparation for quick invasion of many more healthy blood cells. Eliminating that protein traps the parasites in the cell.

After an infected mosquito bites a person, malaria parasites move into the liver, where they silently mature and multiply within weeks. Malaria parasites make people sick weeks or months later when they enter red blood cells and begin an exponential expansion. In a single cell, a parasite produces up to 32 offspring in about two days, which burst out to infect more red blood cells.

"This is the stage where things have to happen very fast for the parasite," said senior author Manoj Duraisingh, HSPH assistant professor of immunology and infectious diseases and senior author of the paper in the May 14 Science. "The parasite doesn't like to spend much time outside the cell. It grows and matures, and immediately following rupture, enters a new cell
'/>"/>

Contact: Christina Roache
croache@hsph.harvard.edu
617-384-8979
Harvard School of Public Health
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. A New Twist On Convert to Purchase
2. Latest Twist: Ousted Union Officials Show True Colors By Trying to Stop 29 Union Elections
3. Potential new twist in breast cancer detection
4. A century-old puzzle comes together: Scientists ID potential protein trigger in lung disease sarcoidosis
5. MVP Health Care Eliminates Potential Health Insurance Coverage Gap for Many Young Adults
6. Test Spots Potential Organ Donors Among Coma Patients
7. Potentially Lethal Airborne Fungus May Spread to California
8. MU researchers show potential for new cancer detection and therapy method
9. IMPACT results show potential cancer treatment
10. BATTLE links potential biomarkers to drugs for lung cancer
11. New phase II study supports potential of gs-9450 as new treatment option for steatohepatitis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/23/2014)... (PRWEB) August 23, 2014 Teen drug ... Carolina. It’s no different in Wilmington, NC. Substance abuse ... are falling victim to drug and alcohol dependency in ... are looking to overcome substance abuse, but don’t know ... adolescent treatment facility can be a challenge because most ...
(Date:8/22/2014)... The IT manager of Top10BestSEOHosting.com is a web ... He has recently announced that GoDaddy ( http://www.top10bestseohosting.com/go/GoDaddy.com/ ) ... , GoDaddy is a popular supplier of cheap web ... solutions at affordable rates. It offers three Linux shared ... depend on the length of the contract. The longest ...
(Date:8/22/2014)... Today, Zane Benefits, the #1 Online ... Health Plans. , According to Zane Benefits, employers are ... lower the cost of healthcare without reducing coverage for ... however, can be confusing. , The new guide contains ... main types of ABHPs. It also explains the ...
(Date:8/22/2014)... Recently, UWDress.com, a leading online supplier of ... new range of empire bridesmaid dresses to its ... a summer promotion for these high quality items. All of ... to 75 percent off. , The company’s new items ... efficient assistance on its website. It is true that all ...
(Date:8/22/2014)... Jose, CA (PRWEB) August 22, 2014 ... now offering a new teeth whitening technique. Air polishing ... regular cleaning appointments. , Dark teeth can be caused ... two categories: external stains and internal stains. External stains ... stains can be caused by certain medications, such as ...
Breaking Medicine News(10 mins):Health News:Troubled Teens Wilmington Helpline Guides Adolescents to the Path of Recovery 2Health News:Discounted Empire Bridesmaid Dresses Online At UWDress.com 2Health News:Japantown Dental Introduces Air Polishing 2
... The national recession didn,t just hit people living in the ... pay for medical bills in poor countries like Honduras, according ... opportunities have dried up for Latino immigrants in the U.S., ... ill family members in their home countries, according to a ...
... chemotherapy have dramatically improved the outlook for many cancer ... daunting. A new generation of chemotherapy drugs with fewer ... assistant professor of chemistry at the University of Cincinnati. ... these new anticancer agents Tuesday, March 27, at The ...
... MONDAY, March 26 (HealthDay News) -- Women should be ... death among women in the United States -- during ... study suggests. Researchers from Mount Sinai Medical ... performed during visits to obstetrician/gynecologists could help identify women ...
... study presented at the Society of Interventional Radiology,s 37th ... light at the end of the tunnel for individuals ... procedure called irreversible electroporation or IRE uses microsecond electrical ... a vast and delicate network of blood vessels of ...
... launched a major clinical trial to investigate whether eliminating a ... in some patients. The Helicobacter Eradication Aspirin ... Helicobacter pylori in the gut of patients taking ... chances of developing a stomach ulcer and dangerous associated bleeding ...
... that very few young women with cancer take steps to ... of young women are more likely to do so than ... journal of the American Cancer Society, the study indicates that ... reproductive-aged women diagnosed with cancer. More than 120,000 women ...
Cached Medicine News:Health News:US economic woes ripple all the way to Latin America, U-M study shows 2Health News:Progress toward new chemotherapy agents 2Health News:Ob/Gyn Visit a Good Time to Screen for Heart Disease: Study 2Health News:Electrical pulse treatment gives pancreatic cancer patients new hope 2Health News:Can eradicating a common stomach bug make taking aspirin safer? 2Health News:Few young women with cancer take steps to preserve fertility during treatments 2
(Date:8/21/2014)... 2014   Memorial Hermann Health System and ... announced a new partnership to provide a new level of ... centers in the greater Houston area. ... the exclusive provider of professional breast radiology services for five ... City, The Woodlands , Northeast, Southwest and ...
(Date:8/21/2014)... 2014 The spinal column is one of the ... carried to and from the brain through the column control ... Injury or ailment here can be life altering, and leave ... control over their body. Though back injury and disease can ... are more options available to make things better than ever ...
(Date:8/21/2014)... BURLINGTON, Mass. , Aug. 21, 2014 /PRNewswire/ ... of COPD,  physicians in Brazil ... to follow clinical guidelines and commonly prescribe long-acting ... regimens, although they do so within current severe ... combinations (FDCs) that are expected to launch in ...
Breaking Medicine Technology:Memorial Hermann, MD Anderson join forces to provide enhanced breast imaging services throughout the Greater Houston Region 2Memorial Hermann, MD Anderson join forces to provide enhanced breast imaging services throughout the Greater Houston Region 3Memorial Hermann, MD Anderson join forces to provide enhanced breast imaging services throughout the Greater Houston Region 4Don't Live in Pain: Four Life Improving Benefits of Back Surgery 2Novel Fixed-Dose Combinations for COPD in Brazil and Mexico Will Compete With Well-Established Therapies in an Environment Dominated by Aggressive Cost-Control Mechanisms 2Novel Fixed-Dose Combinations for COPD in Brazil and Mexico Will Compete With Well-Established Therapies in an Environment Dominated by Aggressive Cost-Control Mechanisms 3
... March 14, 2011 Bionovo, Inc. (Nasdaq: BNVI ) ... quarter of fiscal year 2010 ended December 31, 2010 on Tuesday, ... webcast to review the financial results on Tuesday, March 15, 2011, ... call by dialing 1-888-428-7458, or can listen via a live audio ...
... /PRNewswire-Asia-FirstCall/ -- China-Biotics, Inc. (Nasdaq: CHBT ) ... distributor of probiotics products in China, today announced the ... held on Wednesday, March 9, 2011 for stockholders of ... Offices at No. 26, Orient Global Headquarter, Lane 118 ...
Cached Medicine Technology:China-Biotics, Inc. Announces the Results of the 2010 Annual Meeting of Stockholders 2
... cannula which contains a coaxial 12 Fr ... Basket and a Tip Deflecting Wire Guide. ... cannula to carry these two instruments, via ... (Requires a Handle for Tip Deflecting Wire ...
The only solution for in-line digital measurement...
PEACOCK from NOMOS is a complete treatment,planning and delivery system exclusively designed,to support intensity modulated radiation therapy,(IMRT). PEACOCK is comprised of two breakthrough,...
... dedicated system for non-invasive ... (SRS/SRT), represents cutting-edge technology ... of brain as well ... tumors, arteriovenous malformations and ...
Medicine Products: