Navigation Links
New tumor tracking technique may improve outcomes for lung cancer patients
Date:11/19/2012

PHILADELPHIA Medical physicists at Thomas Jefferson University and Jefferson's Kimmel Cancer Center are one step closer to bringing a new tumor-tracking technique into the clinic that delivers higher levels of radiation to moving tumors, while sparing healthy tissue in lung cancer patients.

Evidence has shown a survival advantage for lung cancer patients treated with higher doses of radiation. Therefore, there is an increased interest to find novel ways to better track tumorswhich are in constant motion because of breathingin order to up the dosage during radiation therapy without increasing harmful side effects

After proving its success in simulations, researchers have now shown that their real-time tracking technique can achieve such tasks. Not only can it better predict and track tumor motion and deliver higher levels of radiation to lung cancer patients and others with moving tumor targets, it can also successfully be implemented into existing clinical equipment (i.e., Elekta Precise Table).

The results of the study, led by Ivan Buzurovic, Ph.D., a medical physics resident and researcher in the Department of Radiation Oncology at Thomas Jefferson University, and Yan Yu, Ph.D., Professor, Vice Chair and Director of Medical Physics at Thomas Jefferson University, were published in the November issue of Medical Physics.

"We've shown here that our system can better predict and continuously track moving tumors during radiotherapy, preventing unnecessary amounts of radiation from being administered to unnecessary areas," said Dr. Buzurovic. "Just as important, we've successfully modified existing technology to integrate with the system to perform the tracking and delivery, meaning no additional robotic systems is needed."

Respiratory and cardiac motions have been found to displace and deform tumors in the lung and other organs. Because of this, radiation oncologists must expand the margin during radiotherapy, and consequently a large volume of healthy tissue is irradiated, and critical organs adjacent to the tumor are sometimes difficult to spare.

In an effort to shrink that margin, Jefferson researchers developed a new, robotic technique that better tracks tumor motion to deliver more precise radiation.

Here, the researchers applied a new control system (software and hardware) and robotic technology to existing treatment couches used for radiation therapy to determine the tracking technology's feasibility in a clinical setting.

They found the technology can be integrated onto treatment couches and validated the tumor tracking system capabilities to follow desired trajectories. When the active tracking system was applied, irradiated planning target volume (the area set for treatment) was 20 to 30 percent less for medium size tumors and more than 50 percent for small size tumors.

"The use of tumor tracking technology during radiotherapy treatment for lung cancer would result in significant reduction in dose to critical organs and tissue, potentially decreasing the probability or severity of side effects, and thus improving cancer treatments," Dr. Yu said.

Based on these results, it can be hypothesized that clinical implementation of real-time tracking is feasible for achieving potentially improved patient outcome.

"With this new technique, it shrinks the margin, and radiation oncologists would be able to administer more radiation and faster to the tumor than conventional methods," said Adam P. Dicker, M.D, Ph.D., Professor and Chairman of the Department of Radiation Oncology at Thomas Jefferson University. "And a higher, more targeted dose means a better cure in lung cancer."


'/>"/>

Contact: Steve Graff
stephen.graff@jefferson.edu
215-955-5291
Thomas Jefferson University
Source:Eurekalert

Related medicine news :

1. Study offers clues to cause of kids brain tumors
2. Cancer therapy -- Nanokey opens tumors to attack
3. For brain tumors, origins matter
4. Moffitt Cancer Center researchers identify novel metabolic programs driving aggressive brain tumors
5. New targeted therapy for advanced prostate cancer shows anti-tumor activity in clinical trials
6. New monoclonal antibody inhibits tumor growth in advanced solid tumors in phase I clinical trial
7. Laser-light testing of breast tumor fiber patterns helps show whose cancer is spreading
8. IU researchers report first effective treatment of tumors arising from common genetic disease NF1
9. Quality of Life After Cancer May Depend on Tumor Type
10. Socioeconomic disadvantage linked to breast cancer tumor disparity
11. Minorities most likely to have aggressive tumors, less likely to get radiation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/24/2017)... ... February 24, 2017 , ... Castle Farms, ... their Military Wedding Giveaway, with the winning couple announced on Feb. 14, 2017, ... generously donated from local vendors: A Matter of Taste, Ryan Rousseau Enterprises, A ...
(Date:2/23/2017)... ... February 23, 2017 , ... The Lymphoma ... innovative lymphoma research and serving the lymphoma community through a comprehensive series of ... Gorce Country Club in Miami Beach to host its Swirl: Miami Wine Tasting ...
(Date:2/23/2017)... North Hollywood, CA (PRWEB) , ... February 23, 2017 , ... ... are pleased to announce that they are sponsoring a raffle. Throughout the month of ... drawing. Winners will receive a gift card for a dinner for two at the ...
(Date:2/23/2017)... ... ... Dr. David Mahon leads Siena Dental, a comprehensive dental practice located at ... Top Patient Rated Henderson Dentist by Find Local Doctors earlier this year. ... dentists who have earned high ratings and superior patient reviews from multiple credible sources. ...
(Date:2/23/2017)... ... February 23, 2017 , ... Healthcare ... for those in the fight against cancer, has produced a seminal study that ... HRA will release top-line findings in a webinar, Defining Compassionate Care Through the ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... , Feb. 24, 2017  Xynomic Pharmaceuticals, Inc., ... announced that it has acquired exclusive worldwide rights ... best-in-class innovative HDAC inhibitor targeting hematological and solid ... 14 Phase 1 and 2 clinical trials of ... have already been completed, demonstrating that ...
(Date:2/23/2017)... 23. Februar 2017 LG Innotek hat heute ... Die Sterilisationsleistung beträgt das 1,5-fache des 45-mW-Moduls der Konkurrenz. ... Bereich zwischen 200 und 280 nm und eignet sich damit ... es ihre DNA zerstört. Das Produkt von LG Innotek ... ...
(Date:2/23/2017)... China , 23. Februar 2017 Im ... , eine nationale Wirtschaftszone in der südwestlichen chinesischen Provinz Guizhou, ... der Errichtung einer Innovationsplattform aktiv an der Entwicklung einer eingebetteten ... Continue Reading ... ...
Breaking Medicine Technology: