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New tumor-targeting agent images and treats wide variety of cancers
Date:6/11/2014

y different cancers that tested positive. The APC analogs even sometimes revealed other sites of cancer in patients that were small, asymptomatic and previously undetected by physicians."

Kuo specializes in the treatment of brain tumors, and also leads the UWCCC CNS Tumors group running many clinical trials for glioma, a brain cancer that is incurable because current treatments leave behind cancer stem cells that can seed and regrow the cancer. He says it was encouraging that the APC analogs also picked up cancer stem cells and will also likely target them for further treatment.

"It's also potentially superior to current imaging methods because the standard clinical MR or PET imaging may give false-positive results due to surgical scars, post-treatment effects, inflammation, or even infection, making it difficult to know if the cancer has truly returned,'' he says.

Kuo says the fluorescent intraoperative APC imaging might help make cancer surgeries more effective and safer; any cancer cells that cannot be safely removed can be targeted afterwards with radioactive APC therapy. In addition, APC imaging might avoid the "false positive" results of current imaging, so cancer patients can stay on effective therapies and likely avoid the risks and costs of "second look" surgeries.

The large multidisciplinary study team is also led by co-lead author Dr. Jamey P. Weichert, associate professor of radiology, who cofounded and serves as chief scientific officer of Cellectar Biosciences, Inc., the Madison-based company developing the APC analog platform for cancer imaging and therapy.


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Contact: Susan Lampert Smith
ssmith5@uwhealth.org
608-890-5643
University of Wisconsin-Madison
Source:Eurekalert

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