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New treatments offer better survival and fresh challenges in colorectal cancer
Date:8/21/2009

out half of patients with CRC from an ineffective, but potentially harmful (and expensive) therapy with cetuximab and panitumumab.

Clinical decisions regarding whether the goal is to rapidly shrink a tumour, whether to attempt curative surgery or to rapidly boost short-term quality of life or survival, or instead aiming for a longer-term quality of life with minimum side effects will determine the physician's choice of approach.

"Although biomarkers will provide some guidance on which agents are potentially useful in a given setting, in particular with regard to the use of EGFR antibodies, the importance of individualizing therapy based on clinical parameters cannot be overemphasized," says Grothey.

Targeted agents have become an integral part of medical therapy for advanced CRC. The next challenge for oncologists is to develop a rationale and biomarker-based treatment algorithm to use all potentially active agents as individualized therapy.


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Contact: Mithu Mukherjee
mithu.mukherjee@sagepub.co.uk
44-207-324-2223
SAGE Publications UK
Source:Eurekalert

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