Navigation Links
New treatment method safe, effective for advanced melanoma patients
Date:6/5/2010

CHICAGO, June 5 Patients undergoing treatment for melanoma that has spread to the liver may respond well to chemotherapy delivered directly into the liver's blood vessels, according to a study sponsored by the National Cancer Institute and Delcath Systems Inc., and led by James F. Pingpank, M.D., associate professor of surgery, University of Pittsburgh School of Medicine, and surgical oncologist with UPMC Cancer Centers. The results will be disclosed in an oral presentation on June 5 in Chicago at the 46th annual meeting of the American Society of Clinical Oncology (ASCO).

"Once melanoma spreads to the liver, a patient's life expectancy typically ranges from six to nine months," said Dr. Pingpank. "We hoped this study would not only show an increase in progression-free survival rates for these patients, but also lead to a standard of care for the disease."

The phase III trial enrolled 93 patients from 10 different sites across the country between February 2006 and October 2009. Its primary goal was to double the length of hepatic progression-free survival for patients with melanoma that had spread to the liver. Patients received either percutaneous hepatic perfusion (PHP) with the drug melphalan, meaning the chemotherapy was delivered directly into the blood vessels of the liver, or the treatment considered the best alternative regimen by their treating physician. If a patient not receiving PHP had disease progression, he or she could cross over to the PHP arm of the trial.

"Not only did we achieve our goal, we surpassed it," said Dr. Pingpank. "This is particularly exciting because so far oncologists haven't been able to recommend a standard of care for patients with melanoma that has spread to the liver. PHP appears to control tumors in the liver and extend life expectancy for these patients, whether their melanoma began as skin cancer or as ocular melanoma, a less common form of the disease that starts in the eye. Fifty percent of ocular melanoma patients will experience liver metastasis, so these findings are crucial for them."

Melanoma is a rare form of cancer, but it causes the majority of skin cancer-related deaths. Each year, approximately 160,000 new cases are diagnosed worldwide. Ocular melanoma will be diagnosed in approximately 2,500 adults this year.


'/>"/>

Contact: Courtney McCrimmon
McCrimmonCP@upmc.edu
412-715‑8894
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Related medicine news :

1. Combination treatment regimen not effective against advanced melanoma
2. Researchers Report Treatment Headway Against Lung Cancer
3. Nasendoscopy proves useful in predicting treatment success in sleep apnea patients
4. Mount Sinai researchers approaching universal treatment for all strains of influenza
5. New Website Created Just For Car Accident Victims… Reveals Chiropractic Treatment Is Extremely Effective For Whiplash, Neck and Back Pain
6. The Harley Medical group launches exclusive treatment for stretch marks and scars
7. Local Walgreen's Drug Stores Now Stock ZymaDerm™ The Painless Treatment for Molluscum Contagiosum
8. UT Southwestern investigators perform head-to-head comparison of incontinence treatments
9. New cancer guidelines: Exercise during and after treatment is now encouraged
10. Acne Treatment Reviewed by Leading Dermatologists in Honor of Acne Awareness Month
11. Hair Loss Research Study Reveals Important Breakthrough in the Treatment of Male Pattern Baldness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2017)... ... 2017 , ... In any business, follow up is critical to success. It ... at presenting treatment, there will always be some patients who can’t or won’t make ... best practices when it comes to presenting treatment. After the patient leaves, most ...
(Date:5/26/2017)... , ... May 26, 2017 , ... ... met this week to review more than eighty-nine grant submissions all vying for ... young scientists in the Parkinson’s field.     , The American Parkinson Disease Association (APDA) ...
(Date:5/26/2017)... ... May 26, 2017 , ... Somnoware, a leading ... sleep monitor with its Somnoware Sleep Device Interface (SDI). Somnoware SDI is a ... operations. With this platform, initializing devices and importing studies are just one-click operations. ...
(Date:5/26/2017)... , ... May 26, 2017 , ... On May 24, ... which narrowly passed the U.S. House on May 4, would result in 23 million ... under continued implementation of the 2010 Patient Protection and Affordable Care Act (ACA). ...
(Date:5/26/2017)... ... 2017 , ... Rob Lowe acts as host and helps educate and inform ... hiking in American. Viewers can reconnect with America as it explores some of the ... consumers have looked for an inventive new place for a family vacation, and have ...
Breaking Medicine News(10 mins):
(Date:5/24/2017)... , May 24, 2017  ivWatch LLC ... Equipment Manufacturer (OEM) Board to enable seamless integration ... patient monitoring systems, infusion pumps and other devices. ... will be able to help health care customers ... reduced risks related to IV therapy. ...
(Date:5/22/2017)... 22, 2017  As the specialty pharmacy industry ... to make the revolutionary shift from volume-based to ... ensuring positive patient outcomes and shaping the future ... focus away from clinical trials and toward data ... specialty drug therapy utilization in precise patient populations. ...
(Date:5/15/2017)... -- Amy Baxter MD, chief executive officer and founder of ... was awarded a 2017 Top 40 Healthcare Transformer designation ... the MM&M Top 40 Healthcare Transformers dinner and awards ... May 10, 2017. The dinner followed a full-day conference ... pill."  "Innovation goes beyond invention," noted Baxter ...
Breaking Medicine Technology: