Navigation Links
New treatment holds promise for resistant lung cancer
Date:4/9/2013

WASHINGTON, DC (April 9, 2013)A new chemotherapy regimen appears to produce minimal side effects in patients with lung cancer that has not responded to previous therapy, paving the way for additional research to determine if the new regimen also helps shrink tumors, according findings to be presented by Fox Chase Cancer Center researchers at the AACR Annual Meeting 2013 on Tuesday, April 9.

"I'm very optimistic that we will show this protocol helps lung cancer patients who have run out of other options," says study author Hossein Borghaei, MS, DO, director of Thoracic Medical Oncology at Fox Chase. "For this patient population, we are in desperate need of new treatments."

All of the patients included in the study had non-small cell lung cancer, the most common form of lung cancer. In the U.S., more patients die of lung cancer than any other cancer. All had tried at least one other treatment, but their tumors had continued to grow.

Once patients fail to respond to one therapy, additional treatments are less likely to work, says Borghaei. For patients with treatment-resistant lung cancer, there is often little hope. But in the labs of Fox Chase, researchers have found evidence that a new combination of existing chemotherapy drugs could have an effect on these types of tumors.

The first drug, Tarceva (erlotinib), blocks a pathway many tumors use to grow. The drug works particularly well in lung tumors that carry a mutation which accelerates that particular pathway. None of the patients included in the study carried this mutation, but research suggests they may still see some benefit from Tarceva.

The other drug, Alisertib (MLN8237), prevents chromosomes from splitting normally during cell division, causing cells to die. Since tumors depend on cell division to grow, the drug is being investigated in a number of different types of cancer.

If the drugs work better together than apart in lung tumors, that would make sense, says Borghaei. "What we've found through many years of research is that it's often better to combine chemotherapy drugs that target different aspects of cancer than to use either alone."

To test this theory, Borghaei and his colleagues gave four different doses of the drugs to 10 patientsthe first stage of clinical testing that determines the maximum dose that people can safely tolerate.

Encouragingly, the side effects were "manageable," says Borghaei. One person experienced hair loss and lower counts of blood cells that fight infection, but has not developed any infections, he says. Other patients reported some mild fatigue, "but nothing out of the ordinary that would make us say this is an intolerable regimen," he says.

Although the research is not far enough along to know if the treatment works, 2 patients' tumors stopped growing while taking the drugs. Three patients have unfortunately died, but only after they'd stopped the treatment because their tumors didn't respond.

Borghaei cautions that in such early stages of the research, it's too soon to tell if the treatment works. "Both patients whose tumors stabilized were given the maximum dose of both drugs, and I hope that once we progress in the trial and treat more patients at the maximum doses, we will see more responses," he says. "I want everyone to respond."


'/>"/>

Contact: Diana Quattrone
diana.quattrone@fccc.edu
215-728-7784
Fox Chase Cancer Center
Source:Eurekalert

Related medicine news :

1. Siberian Pine Nut Oil Provides Tips for Treatment of Gastritis
2. A New Peer-Reviewed Study Using CogniFit Brain Training Provides A Breakthrough In The Treatment Of Insomnia
3. Top Provider of Hearing Aids in Marina del Rey CA, American Hearing & Balance, Now Offers New Balance Disorder Treatment
4. Diabetes patients need to be consulted to improve treatment
5. Extracellular vesicles may open new opportunities for brain cancer diagnosis and treatment
6. Rejuv Medical Announces Stem Cell Treatments Now Available
7. Different drug combinations work best for prevention versus treatment of colorectal tumors
8. Fatty Liver Treatment
9. How “Fatty Liver Diet Guide” Helps People Treat Fatty Liver Quickly – Vkool.com
10. Flies model a potential sweet treatment for Parkinsons disease
11. New minimally invasive, MRI-guided laser treatment for brain tumor found to be promising in study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... IL (PRWEB) , ... October 13, 2017 , ... ... which established the certification process to promote standards of excellence for the field ... Symposium, scheduled for March 22 – 25, 2018 in Orlando, Florida at the ...
(Date:10/13/2017)... ... , ... Many families have long-term insurance that covers care for a family ... for care if the client has a cognitive impairment diagnosis. , “What this ... often waived, so the benefits from their insurance start immediately,” said Mechell Vieira, owner ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... ... will be giving viewers the lowdown on sciatica in a new episode of ... that focuses on current events and innovation and investigates each subject in-depth with ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and San ... using cutting-edge Oventus O2Vent technology. As many as 18 million Americans are ... cessation in breathing. Oral appliances can offer significant relief to about 75 percent ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... AccentCare, a leader in post-acute health care, have expanded their existing home health ... Home Health. , AccentCare has been operating a joint venture home health company ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... Calif. , Oct. 10, 2017  NDS received FDA 510(k) ... — a medical-grade battery-powered display stand specifically designed for endoscopy environments. ... transform technology into a clinical solution to support the improvement of ... Innovative Design ... Mobile Wireless Solution ...
(Date:10/7/2017)...   Provista, a proven leader in the ... purchasing power, today announced a new resource area on ... is the online home for case studies, articles ... news releases, slideshows and events. ... resources at their fingertips, viewers can also watch short ...
(Date:10/4/2017)... , Oct. 4, 2017  South Korean-based healthcare ... CPR training aide "cprCUBE" on Kickstarter. The device will ... during cardiac arrests with better efficiency compared to the ... offers real-time feedback on efficacy of the compression for ... campaign has a goal to raise $5,000. ...
Breaking Medicine Technology: