Navigation Links
New treatment gives hope for pulmonary fibrosis patients
Date:5/20/2008

ATS 2008, TORONTOPatients with idiopathic pulmonary fibrosis (IPF) may have a new treatment option, according to researchers in Japan.

In a Phase III, double-blind, placebo-controlled clinical trial, the investigators discovered that a daily dose of pirfenidone could slow the progression of IPF, reducing the loss of lung capacity. The results will be announced at the American Thoracic Societys 2008 International Conference in Toronto on Tuesday, May 20.

The most common treatment for IPF is anti-inflammatory agents such as steroids, said lead researcher Takashi Ogura, M.D., of Kanagawa Cardiovascular and Respiratory Center in Yokohama, Japan. However our study confirmed that pirfenidone, the main action of which is thought to be antifibrotic, achieved a therapeutic effect on IPF. I expect that our study will serve as a guide to develop a new therapy for IPF in the future.

The researchers recruited a total of 275 Japanese patients with mild to moderate IPF and randomized them to a high dose pirfenidone (1,800 mg/day) group, a low dose pirfenidone group (1,200 mg/day) and a placebo group. They measured lung capacity (vital capacity or VC) and progression-free survival, defined as a period without death or a greater than 10 percent decrease in VC, to determine the effectiveness of the regimens.

At the end of one year, they found that patients who had been randomized to the high dose regimen had significantly lower loss of VC than the placebo group. Furthermore, pirfenidone slowed the overall deterioration of IPF compared to the placebo.

Taken altogether, our study demonstrated positive clinical effects of pirfenidone that suppresses the progress of IPF and potentially contributes to improving the outcomes of patients with IPF, said Dr. Ogura.

Pirfenidone represents new hope, not only for IPF patients who currently have no curative treatment options, but because it is thought to be an antifibrotic agent, it may be able to treat other fibrotic lung diseases, such as interstitial pneumonia with collagen vascular disease and extrapulmonary fibrosis.

We will continue the follow-up of the patient cohort included in this study to identify whether pirfenidone can contribute to prolonged survival in patients with IPF, said Dr. Ogura. Other clinical studies of pirfenidone are also being conducted in the U.S. and Europe, and we hope that our results will be replicated there.


'/>"/>

Contact: Keely Savoie
ksavoie@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. Mission Pharmacal Launches Ferralet(R) 90 for Treatment of the Leading Cause of Anemia in the U.S.
2. Monitoring whether patients take medicines can help anticipate HIV treatment failure in Africa
3. Mapping of prostate cancer genes opens the door to new treatments
4. Many Diabetics Dont Get Necessary Blood Pressure Treatment
5. MR imaging accurately determines prostate cancer treatment failure
6. Study: Patients 75 years and older with brain tumors may benefit from more aggressive treatment
7. Old antibiotic may find new life as a stroke treatment
8. Radiofrequency ablation is effective treatment for dysplasia in Barretts esophagus
9. New Hair Loss Treatment Proves Effectiveness
10. Phase 3 GATTEX results presented at DDW highlight potential new treatment in short bowel syndrome
11. Advances Aid Treatment, Diagnosis of Celiac Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/2/2016)... ... 2016 , ... Dr. Rassouli, dentist in Orange County, CA comments ... research, which was published in the “Journal of the American Geriatrics Society,” more than ... Americans have Alzheimer’s disease. The study found that dental problems may increase the risk ...
(Date:5/2/2016)... ... , ... According to an American Psychological Association article, the Centers ... the age of 18. Of those who survive, many still face effects as they ... In her new book, Lyah! Lyah! Pants on Fyah!, she shares stories from women ...
(Date:5/2/2016)... ... May 02, 2016 , ... A research team, ... groundbreaking studies that determined that the adjustability and adaptability of pediatric support surfaces ... of pressure injuries, which are now referred to as “pressure injuries” by the ...
(Date:5/2/2016)... ... May 02, 2016 , ... MedaCheck, a ... and quality outcomes, has announced its partnership with GrandView Health Services. , With ... over the counter and prescription drug pharmacy services to thousands of residents. Serving ...
(Date:5/2/2016)... ... May 02, 2016 , ... One of Hollywood’s best kept ... Dermatology Surgery & Laser Center, in Milford, Penn. “Patients with busy lives want noninvasive ... fat treated and go home or back to work without having to wear recovery ...
Breaking Medicine News(10 mins):
(Date:4/29/2016)... , April 29, 2016 Automation ... science laboratory due to the growing demands for productivity ... technology, contemporary automated systems are already adept of a ... slow, tedious and manual labor. Instrumentation continues to evolve, ... even conceivable just a few years ago. Originally used ...
(Date:4/28/2016)... 2016  Marking its one year anniversary since ... cancer risk test, Color Genomics announced ... highly impact the most common hereditary cancers affecting ... Test analyzes hereditary cancer risks for breast, colorectal, ... The Color Test is physician ordered and includes ...
(Date:4/28/2016)... 2016 , Net Sales of $1.90 billion ... the prior year period, and an increase of 1.2% on ... EPS for the first quarter were $0.52 reported, a decrease ... an increase of 29.9% over the prior year period ... guidance for 2016 Zimmer Biomet Holdings, Inc. (NYSE ...
Breaking Medicine Technology: