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New treatment for severe aortic stenosis shown to save lives, Stanford researchers say
Date:9/22/2010

STANFORD, Calif. - Implantation of a new bioprosthetic-tissue valve into the hearts of patients who have severe aortic stenosis and are too sick or too old for open-heart surgery has been found to both save lives and improve the quality of those lives, according to a new multicenter study, to be published online at 2 p.m. Pacific time today in the New England Journal of Medicine.

The study will also be presented at 8 a.m. Pacific time at the Transcatheter Cardiovascular Therapeutics Conference in Washington, D.C. on Sept. 23.

"This is exciting because it does save lives and is a major medical paradigm shift," said D. Craig Miller, MD, the Thelma and Henry Doelger Professor of Cardiovascular Surgery at the Stanford University School of Medicine and one of the manuscript's principal authors. "These patients were really sick with a fatal problem, and now they're feeling better and staying out of the hospital. Before, there was nothing we could really offer them."

Stanford University Medical Center was one of 21 institutions to participate in the study, known as the PARTNER Trial. It is the first randomized clinical trial comparing the efficacy of using a transcatheter heart valve called "TAVI" - which is implanted percutaneously through an artery in the groin directly into the beating heart - with routine medical therapy, which includes aortic balloon valvuloplasty to relieve symptoms. The trial was sponsored by Edwards Lifesciences Corp., based in Irvine, Calif., which designs, manufactures and markets tissue heart valves.

A total of 358 patients with severe aortic stenosis, a heart disease characterized by obstruction of the aortic valve due to calcification, participated in the trial. The patients who qualified were debilitated by the disease, which causes shortness of breath, fatigue and congestive heart failure. While the standard of care for most patients with this condition would be open-heart surgery to replace t
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Contact: Tracie White
traciew@stanford.edu
650-723-7628
Stanford University Medical Center
Source:Eurekalert

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