Navigation Links
New treatment for advanced prostate cancer
Date:7/29/2008

Researchers at the University of Adelaide have developed a novel approach to treating advanced prostate cancer that could be more effective with fewer side effects.

Professor Wayne Tilley and Dr Lisa Butler of the University's Dame Roma Mitchell Cancer Research Laboratories have discovered that by using existing prostate cancer drugs in combination with new drugs at lower doses, they can expect to generate better results for patients than current treatments.

Growth of prostate cancer is initially dependent on hormones called androgens, which traditionally have been suppressed to stop tumour growth. However, despite an initial response, resistance to hormone deprivation often occurs and the tumour starts to grow again, Professor Tilley says.

"Men undergoing hormone deprivation therapy can also experience significant side effects, including reduced libido, impotence, hot flushes, tiredness and sweating, gradual decrease in body hair, reduced bone and muscle strength and cognitive changes," he adds.

Professor Tilley and Dr Butler have successfully killed prostate cancer cells in laboratory studies using low doses of a combination therapy of drugs including bicalutamide (an anti-androgen that opposes the action of androgen on the tumour), and the inhibitors 17AAG and vorinostat.

These new drugs block key cancer survival pathways, but are not particularly effective in killing prostate cancer cells if given alone.

"We can now confirm that a very low level of bicalutamide is capable of inhibiting cancer cell proliferation by more than 10-fold when combined with either vorinostat or 17AAG, making our current treatments much more effective and causing fewer side effects," says Dr Lisa Butler.

All the drugs needed for combination therapy are already approved for use in clinical trials, so the new therapy can be readily tested in patients with advanced prostate cancer.

Professor Chris Sweeney, a world recognised medical oncologist and Director of Clinical Trials at the Royal Adelaide Hospital Cancer Centre, will lead a multidisciplinary team to test the new treatment.

"The ultimate test of this exciting laboratory breakthrough is to see if it improves outcomes and quality of life for men suffering from advanced prostate cancer," he says.

"The strong partnership between medical scientists and clinicians at the University of Adelaide and the Royal Adelaide Hospital means patients can benefit from advances in medical science much faster than in the past."


'/>"/>

Contact: Wayne Tilley
wayne.tilley@adelaide.edu.au
61-882-223-252
University of Adelaide
Source:Eurekalert

Related medicine news :

1. New therapy for HIV treatment
2. Alzheimers Treatment Trials May Have Special Challenges
3. Elekta Family of Companies to Highlight Cancer Treatment Solutions at 2008 AAPM Annual Meeting
4. Mt. Sinai's Children's Trauma Institute Treatment and Service Adaptation Center Receives Video Conferencing Donation From IVCi
5. Researchers disprove long-standing belief about HIV treatment
6. Neurotherapeutics presents special issue on new treatments for Alzheimers disease
7. Clinical Trial Concluded For New Wrinkle Treatment
8. Has cancer spread? Research identifies best way to find answers so treatment can begin
9. Minimally Invasive Treatment Improves Male Fertility
10. Minimally invasive treatment improves male fertility
11. Clinical Trial for the Treatment of Inflammatory Bowel Disease Begins at Tel Aviv Sourasky Medical Center
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Apple ... care services, staged a mock evacuation of the facility as part of a disaster ... Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Global Healthcare Management’s ... Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s ... The fun run is geared towards children of all ages; it is a ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the ... danger possible to save lost souls in the Philippines. “The Journey: From the Mountains ... a dedicated teacher of the Bible. She has taught all ages and currently teaches ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and ... plans to open a flagship location in Covington, LA at 401 N. U.S. Highway ... store next to Office Depot in the Holiday Square shopping center. Its location allows ...
(Date:10/12/2017)... ... 2017 , ... Asante, a nationally recognized health system in ... existing home health joint venture through an agreement, effective October 1, 2017, to ... home health company with Asante, delivering clinically integrated care, for the past eight ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... -- NDS received FDA 510(k) clearance in May 2017 for its highly ... designed for endoscopy environments. An innovative secondary monitor solution, ZeroWire ... support the improvement of patient outcomes, procedural efficiency, and the lowering ... ... ...
(Date:10/4/2017)... 4, 2017  South Korean-based healthcare product Development Company ... "cprCUBE" on Kickstarter. The device will educate the user ... with better efficiency compared to the dated and pricey ... on efficacy of the compression for a more informed ... goal to raise $5,000. ...
(Date:10/2/2017)... 2017  Eli Lilly and Company (NYSE: ... third quarter of 2017 on Tuesday, October 24, 2017. ... day with the investment community and media to further ... call will begin at 9 a.m. Eastern time. Investors, ... webcast of the conference call through a link that ...
Breaking Medicine Technology: