Navigation Links
New treatment could combat deadly chemical agents
Date:1/11/2013

An enzyme treatment which could neutralise the effects of lethal chemicals responsible for the deaths of hundreds of thousands of people across the world has been developed by experts at the University of Sheffield.

Organophosphorus agents (OP) are used as pesticides in developing countries and acute poisoning is common because of insufficient control, poor storage, ready availability, and inadequate education amongst farmers.

It is estimated about 200,000 people die each year across the world from OP poisoning, through occupational exposure, unintentional use and misuse, mostly in developing countries like India, Pakistan, and Sri Lanka and through deliberate terrorist activities. OPs include compounds like Tabun, which was developed in 1936 by German scientists during World War II, Sarin, Soman, Cyclosarin, VX, and VR.

Using a modified human enzyme, scientist Professor Mike Blackburn from the University of Sheffield's Department of Biomedical Sciences collaborated in a consultancy role with Professor Alexander Gabibov of the Shemyakin-Ovchinnikov Institute, Moscow, and Professor Patrick Masson of the Dpartement de Toxicologie, Centre de Recherches du Service de Sant des Armes, to create a "bioscavenger" which was found to protect mice against the nerve agent VR and showed no lasting effects.

In studies performed at the Institute of Bioorganic Chemistry in Pushchino, Russia, a total of eight mice were treated with the new enzyme after being subjected to enough of the VR agent to kill several of the animals about 63 mg and all survived.

Professor Blackburn said: "This current publication describes a novel method to generate a bioscavenger for the Russian VR organophosphorus agent with the key property of being long-acting in the bloodstream.

"That has been achieved by a combination of chemical surface modification (polysialylation) and biotechnology of production (through the use of an in vitro CHO-based expression system employing genes encoding butyrylcholinesterase and a proline-rich peptide under special promoter control).


'/>"/>

Contact: Paul Mannion
p.f.mannion@sheffield.ac.uk
01-142-229-851
University of Sheffield
Source:Eurekalert

Related medicine news :

1. More Focused Radiation Treatment May Work Better Against Brain Tumors
2. Many U.S. Teens at Risk for Suicide Despite Treatment: Study
3. Regenerative medicine: Clinical trials launched for the treatment of delayed union fractures
4. Researchers reveal most effective treatment for common kidney disorder
5. Changing Poses LLC Brings Balance to Chiropractic Treatment Tables, Complimentary Lavender Spray Cleaner with All Wholesale Orders
6. Black and Hispanic patients less likely to complete substance abuse treatment, Penn study shows
7. Sublingual immunotherapy shows promise as treatment for peanut allergy
8. U.S. Medical Waste Market Analysis: Treatment, Containment, Management and Disposal Products Reviewed in New Research Report at ReportsnReports.com
9. Mayo Clinic researchers find new molecule to target in pancreatic cancer treatment
10. New understanding of nerve damage caused by spinal cord injury could improve treatment design
11. Some Complain of Shorter Penis After Prostate Cancer Treatment: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... ... March 24, 2017 , ... “Vintage and Harvest A Cultivation ... and college Bible teacher residing in North Carolina with his wife, Anna Marie. He ... them with six grandchildren. David is also the author of “Shadow and Substance.” , ...
(Date:3/24/2017)... ... March 24, 2017 , ... “The Adventures of Joey, The Dog Who Barks ... lives his life to the fullest, as God intended. “The Adventures of Joey, The ... mother and grandmother pursuing her passion for writing, especially about truth and human behavior. ...
(Date:3/23/2017)... ... March 23, 2017 , ... A recent report from the ... teacher preparation programs. The NCTQ report suggests, based on a review of GPA and ... improve teacher quality in the U.S. It argues that this higher bar should be ...
(Date:3/23/2017)... ... March 23, 2017 , ... Demonstrating their commitment to ... public health departments have been awarded national accreditation through the Public Health ... the expanding network of communities across the nation whose health departments meet rigorous ...
(Date:3/23/2017)... ... March 23, 2017 , ... PAINWeekEnd (PWE) Oklahoma City, ... Broadway Avenue, will be an educational and exciting program providing busy clinicians and ... of chronic pain. , Oklahoma is in a healthcare crisis. The state ranks ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... Research and Markets has announced the addition of the "Dental Implants ... ... for Dental Implants in US$ Million. The report provides separate comprehensive analytics ... , Europe , Asia-Pacific , ... Annual estimates and forecasts are provided for the period 2015 through 2022. ...
(Date:3/24/2017)... YORK , March 24, 2017 ... ... a leading publisher of cannabis market research, the legal cannabis ... percent CAGR through 2021, despite conflicting signals from the current ... points out that the two biggest drivers of growth in ...
(Date:3/24/2017)... Research and Markets has announced the addition of the "Deep ... to their offering. ... The Deep Learning: Drug Discovery and Diagnostics Market, 2017-2035 report examines ... deep learning solutions within the healthcare domain. Primarily driven by the ... solution to generate relevant insights from medical data. ...
Breaking Medicine Technology: