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New tool helps identify prostate cancer patients with highest risk of death
Date:10/5/2011

hat are difficult to answer. "We haven't had really had much information to help guide us," Buyyounouski says. "But, we've learned that the sooner a patient experiences biochemical failure after the completion of radiation treatment, the more likely it is that he is going to develop metastases and die of prostate cancer. This new tool uses that information to predict the risk of death on an individual basis."

"With this nomogram, a practitioner can plug in various factors, including the the PSA level, Gleason score, tumor stage, and interval to biochemical failure to get an estimate of the five- and 10-year risk of death. It's a very useful tool."

"The decision to start a new treatment is often difficult to make becuae patients almost always have no symptoms when the PSA levels return. If a patient knew they had a 50% risk of dying of prostate cancer in the next 5 years may make the decision easier," Buyyounouski added

"This tool is also useful for research who are interested in exploring new prostate cancer treatments, before it has had a chance to spread. The nomogram can identify patients at the highest risk of dying." "Unfortunately, patients who have PSA recurrence but no evidence of spread," Buyyounski says, "are often overlooked in clinical trials of new treatments."

For Buyyounouski, the test is a culmination of years of research establishing the validity of using time to biochemical failure as a way of predicting risk of death in prostate cancer patients. He and his collaborators are adapting their work to create an online version of the tool that will be freely available to the public. The tool will be available at the Fox Chase Cancer Center web site early next year.


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Contact: Diana Quattrone
Diana.Quattrone@fccc.edu
215-728-7784
Fox Chase Cancer Center
Source:Eurekalert

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