Navigation Links
New tool for clinicians proves effective predictor of lung cancer risk
Date:8/20/2012

LIVERPOOL, UK 20 August 2012: A lung cancer risk prediction model developed by scientists at the University of Liverpool has been shown to be a viable tool for selecting high risk individuals for prevention and control programmes.

The model, developed at the University's Cancer Research Centre and funded by the Roy Castle Lung Cancer Foundation, was tested in international datasets and found to be a more effective predictor of individuals at risk than smoking duration or family history alone. The results are published in the Annals of Internal Medicine.

Professor John Field, who led the development of the model, said: "Risk prediction models are now considered an important method of identifying high risk patients for cancer screening programmes. Lung cancer kills more people than any other malignancy in the UK, with over 35,000 deaths per year, thus it's imperative that we have a method of identifying individuals with a high risk of developing this disease and investigate appropriately."

The risk model is now being used to select individuals for the UK Lung Cancer CT Screening Trial (UKLS), funded by the National Institute for Health Research Health Technology Assessment Programme (NIHR HTA), which is also run from Liverpool.

The Liverpool Lung Project risk prediction model calculates an individual's chance of developing lung cancer within the next five years. The model currently uses information on smoking duration; previous diagnosis of pneumonia; previous diagnosis of other cancer; occupational exposure to asbestos and relative age at onset of lung cancer diagnosis. The model is also useful for selecting high risk individuals for prevention and control programmes.

The model was validated in three independent studies from Europe and a Harvard case-control study in North America. The analysis demonstrated the model's predicted benefit for stratifying patients for CT screening. The analysis, which incorporated the harms and benefit of using a risk model to make clinical decisions, indicated that the LLP risk model performed better than smoking duration or family history alone in stratifying high-risk patients for lung cancer CT screening.

Professor Field added: "The identification of individuals with a high risk of developing lung cancer who require appropriate investigations and subsequent treatment is the most important area of early lung cancer research today. The potential for lung cancer screening programmes is now a major focus of ongoing UK and international clinical screening trials which potentially could be instigated in Europe within the next three years. We need to be in a position to have validated methods in place to identify individuals for these screening programmes. The validation of the LLP Risk Model now provides the community with a powerful tool for the selection of future patients into such screening programmes."

Paula Chadwick, Chief Executive of the Roy Castle Lung Cancer Foundation, said: "For the majority, lung cancer is characterised by late diagnosis and remains a devastating disease. That is why the Foundation has focused on funding early detection research over many years. We warmly welcome this research publication, in furthering knowledge on lung cancer screening and we thank our supporters, whose generosity has funded this important work."


'/>"/>
Contact: Kate Mizen
kate.mizen@liv.ac.uk
0044-151-794-2247
University of Liverpool
Source:Eurekalert  

Related medicine news :

1. Disorders of consciousness: How should clinicians respond to new therapeutic interventions?
2. New study suggests clinicians overlook alcohol problems if patients are not intoxicated
3. FDA Approves Flu Vaccine for Coming Season
4. Yoga proves to reduce depression in pregnant women, boost maternal bonding
5. Improving the oral health of adults with special needs proves challenging
6. Study: Group yoga improves motor function and balance long after stroke
7. New angioplasty procedure improves blood flow in blocked arteries to extremities
8. Strobe eyewear training improves visual memory
9. HPV improves survival for African-Americans with throat cancer
10. Herbal remedy used to treat hepatitis C proves ineffective, Penn study finds
11. New targeting technology improves outcomes for patients with atrial fibrillation
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New tool for clinicians proves effective predictor of lung cancer risk
(Date:12/2/2016)... Denver, CO (PRWEB) , ... December 02, 2016 , ... ... today announced it has appointed Jason Bice, CPA, MBA to serve as Advanced Inc.’s ... Finance for Advanced, Inc. , Jason brings extensive financial and operational leadership experience ...
(Date:12/2/2016)... ... December 02, 2016 , ... U.S. Surgeon General, Dr. Vivek ... Dr. Murthy explains how he was inspired to practice medicine at an early age ... is about more than making diagnoses and prescribing medicine,” he states. “It is about ...
(Date:12/2/2016)... NY (PRWEB) , ... December 02, 2016 , ... More ... school and while 84 percent of parents report speaking with their child about sex ... and sexually transmitted diseases. , Mediaplanet is proud to announce the launch of its ...
(Date:12/2/2016)... ... 2016 , ... Universal Medical Systems, Inc. (UMS) the world's ... to offer robotic imaging to veterinary medicine is sponsoring the appearance of Millennia, ... American Association of Equine Practitioners 62nd Annual Convention from December 4-6, 2016 in ...
(Date:12/2/2016)... ... 2016 , ... "Pro3rd Accents Volume 2 is a set of 30 accented ... with just a few clicks of the mouse," said Christina Austin - CEO of ... Choose from various styles with accented animations, rigid boxes, simplistic lines, and more. In ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... 2, 2016  UCB is pleased to announce that 12 scientific ... 70 th American Epilepsy Society (AES) Annual Meeting, which ... , USA. 1-12 Data being ... of VIMPAT ® (lacosamide) CV and BRIVIACT ® ... the current state of the union of epilepsy care and ...
(Date:12/2/2016)... , December 2, 2016 The iShares ... past losses following Trump,s victory early in November. Less ... fund managers are now predicting an uptick in M&A ... equities to see how they have fared at the ... ), Amicus Therapeutics Inc. (NASDAQ: FOLD ), ...
(Date:11/30/2016)... -- Research and Markets has announced the addition of ... report to their offering. ... Detachable coil embolization is a minimally ... detachable coil embolization treatment of cerebral aneurysms is less invasive and requires ... in the wall of an artery in the brain. This area bulges ...
Breaking Medicine Technology: