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New tool allows for an alternate method of prostate cancer diagnosis
Date:3/31/2011

ound that changes in gene expression in normal tissue could be detected up to a few millimeters from prostate cancer.

"It is known that at least some prostate cancers cause a reaction in nearby stroma," Mercola said. "However, we were surprised that a reaction may occur for most tumors, and that this response in non-tumor tissue may extend for many millimeters from the tumor."

Ruoxiang Wang, M.D., Ph.D., a research scientist and associate professor in the department of medicine at Cedars-Sinai Medical Center, Los Angeles, said this study represents "one of the few painstaking attempts to define the pathology of tumor-associated stroma in prostate cancer patientsthis study is the first to use clinical specimens in such studies in large scale, while the findings are in such a high statistical significance."

"It is hoped that the large sample size and the high statistical significance of this study may help to ensure a better follow-up, and some of the defined stromal markers will eventually be validated with clinical values," he said.

Further studies will be required to confirm the findings, and before urologists will likely be able to use a diagnosis based on non-tumor tissue for recommending surgery or other radical treatment, according to the researchers. Wang added that these results, if confirmed, could provide guidance to the understanding of the tumor microenvironment, as cancer-stromal interaction plays a pivotal role in prostate cancer progression and bone metastasis.


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Contact: Tara Yates
Tara.Yates@aacr.org
267-646-0558
American Association for Cancer Research
Source:Eurekalert

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