Navigation Links
New therapy to stop progression of fibrosis

Scientists from the University of Sheffield have developed a novel antibody-based therapy which targets the progression of life threating kidney fibrosis.

The ground breaking therapy works by blocking the action of a key enzyme and the treatment should also work for lung, liver and heart fibrosis.

The pioneering biological discovery was made by a research team led by Professor Tim Johnson and Dr Phil Watson, from the University's Academic Nephrology Unit in the Department of Infection and Immunity.

The research, conducted in collaboration with MRC Technology, targets a key step in the progression of fibrosis, which has led to the development of a fibrosis therapy programme and exclusive licensing agreement by global biopharmaceutical company UCB.

There is currently no cure for fibrosis, a primary cause of major organ failure, and a complicating factor in chronic diseases such as diabetes and hypertension.

Professor Johnson said: "The development of these therapeutic antibodies is the culmination of 20 years work to identify the role of a key target in the tissue scarring process where it is possible to understand its mechanism of action and then develop a way to specifically target it.

"This is a fantastic example of how MRC Technology can assist in translating laboratory research to the patient. I am delighted that UCB have licensed the humanised antibodies as the company's expertise in antibody development will ensure patients benefit from this new treatment in the shortest time possible."

He added: " It is also extremely important to recognise that this work would not have been possible without support from charities such as Kidney Research UK, Diabetes UK and the Wellcome trust who have all supported this work."

UCB New Medicines Vice President and Head of Immunology, Dr Mark Bodmer, said: "The program focuses on a key area of unmet medical need and we are committed to bringing fibrosis treatment to patients.

"We are excited to be working with MRC Technology and University of Sheffield scientists to build on their work to date in generating and characterising promising therapeutic approaches with the potential for significant patient impact."

Michael Dalrymple, Director of Business Development at MRC Technology, said: "We are delighted to be able to partner this program with UCB and we look forward to working together to ensure the project's commercial success. This program has the potential to not only benefit fibrosis patients and help prevent organ failure, but also enables MRC Technology and its partners to help bring other new research to market."

Revenue made from the licensing agreement will be shared back with the University and will be reinvested to support other collaborative programs within its drug discovery labs.


Contact: Amy Pullan
University of Sheffield

Related medicine news :

1. Metal implants may cut chemotherapy side effects, study suggests
2. LA BioMed researchers report on promising new therapy for devastating genetic disorder
3. Skin reactions during radiation therapy preventable
4. What is the safest way to stop postmenopausal hormone therapy?
5. Cancer immunotherapy leader Allison to receive 2014 Szent-Gyorgyi Prize
6. Endocrine Society calls for large-scale studies to evaluate testosterone therapy risks
7. The art and science of cognitive rehabilitation therapy
8. Researchers open door to new HIV therapy
9. Music therapys positive effects on young cancer patients coping skills, social integration
10. Long-term follow-up shows need for new chemotherapy strategies for rectal cancer
11. Dr. Leigh Ann Scott to Open Irving Office to Provide Bio-Identical Hormone Therapy
Post Your Comments:
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual Kids ... Milford, NJ. This free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, ... run is geared towards children of all ages; it is a non-competitive, non-timed event, ...
(Date:10/13/2017)... ... ... Journey: From the Mountains to the Mission Field”: the story of a missionary couple ... From the Mountains to the Mission Field” is the creation of published author, Carole ... and currently teaches a class of ladies at her church, which she has taught ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of ... announced today its plans to open a flagship location in Covington, LA at 401 ... Rooms To Go store next to Office Depot in the Holiday Square shopping center. ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, a nationally ... care, have expanded their existing home health joint venture through an agreement, effective ... operating a joint venture home health company with Asante, delivering clinically integrated care, ...
(Date:10/12/2017)... ... October 12, 2017 , ... Leading pediatric oncology experts at ... D.C., for the 49th Congress of the International Society of Paediatric Oncology ... the Center for Cancer and Blood Disorders at Children’s National, and Stephen ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... 2017  AllianceRx Walgreens Prime, the combined central specialty ... pharmacy benefit manager Prime Therapeutics LLC (Prime), today officially ... the unveiling of new signage at its headquarters in ... at a few other company-owned facilities across the country. ... some of whom will begin to see the AllianceRx ...
(Date:9/27/2017)... 2017  Commended for their devotion to personalized service, SMP ... number one in the South Florida Business Journal,s 50 Fastest-Growing ... yearly list, the national specialty pharmacy has found its niche.  ... will soon be honored by SFBJ as the 2017 Power ... Set to receive his award in October, Bardisa said of ...
(Date:9/22/2017)... Sept. 22, 2017  As the latest Obamacare repeal ... Bill Cassidy (R-LA) and Lindsey Graham ... the medical device industry is in an odd place. ... the 2.3% excise tax on medical device sales passed ... want covered patients, increased visits and hospital customers with ...
Breaking Medicine Technology: