Navigation Links
New therapy prevents dangerous side effect for lymphoma patients
Date:12/9/2008

SAN FRANCISCO - Patients respond well to a new three-drug combination for indolent B cell lymphoma that also spares them prolonged, potentially lethal, suppression of blood production in the bone marrow, researchers at The University of Texas M. D. Anderson Cancer Center report today at the 50th annual meeting of the American Society of Hematology.

Pentostatin, cyclophosphamide and rituximab together are providing the same remission rate as other combinations but with minimal long-term bone marrow suppression, said study presenter Felipe Samaniego, M.D., associate professor in M. D. Anderson's Department of Lymphoma and Melanoma.

Myelosuppression leads to production of fewer red blood cells, white blood cells and platelets. When prolonged, it can lead to myelodysplastic syndrome, which comprises several conditions that cause potentially lethal insufficient blood production.

"The worst outcome of long-term myelosuppression for indolent B cell lymphoma patients is myelodysplastic syndrome," Samaniego said. "In this study, out of 80 patients, none developed MDS."

And 77 of 80 (96 percent) experienced either complete remission or unconfirmed complete remission. Some did have low blood counts, but all were short-term. Overall, the combination is well-tolerated, the research team reported.

Prolonged myelosuppression also makes treatment much more difficult if a patient's lymphoma recurs, Samaniego said. "Patients treated with myelosuppressing agents have a difficult time tolerating another round of chemotherapy if their lymphoma comes back."

Indolent B cell lymphomas comprise follicular lymphoma, small lymphocytic lymphoma, and marginal zone lymphoma. These slow-growing but potentially lethal cancers are the most common form of non-Hodgkin lymphoma.

Samaniego and colleagues have been testing new drug combinations against indolent B cell lymphoma that reduce myelosuppression.

Two years ago, a
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

0

GOOD

Page: 1 2

Related medicine news :

1. Intense chemotherapy wards off recurrence in half of mantle cell lymphoma patients after seven years
2. Statin Use Doesnt Inhibit Lymphoma Drug Therapy
3. Three Italian Multicenter Studies Report High (>70%) Rates of Complete Remission (CR) Utilizing Zevalin Radio-Immunotherapy (RIT) in Treatment of Newly Diagnosed or Relapsed or Refractory Non-Hodgkins Lymphoma
4. 33rd Annual Hutch Holiday Gala Raises Millions for Cancer Immunotherapy Research
5. Lenalidomide safe as single therapy for elderly CLL patients
6. Amylin, Lilly Update on FDA Review of BYETTA(R) (exenatide) Injection Monotherapy Submission
7. The St. John-Clark Pain Treatment Center Forms Manual Therapy 'Dream Team'
8. Aggressive Therapy May Stem CF Progression in Infants
9. Washington State Health Care Authority to Launch Medication Therapy Management Initiative
10. MaxCyte to Present Targeted Cancer Immunotherapy Product at 50th Annual Meeting of the American Society of Hematology
11. Oncologists Rank Aloxis Marketing Message Most Influential in the Chemotherapy-Induced Nausea and Vomiting Drug Market
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New therapy prevents dangerous side effect for lymphoma patients
(Date:5/21/2013)... , , MONDAY, May 20 (HealthDay News) -- Long-acting ... chronic obstructive pulmonary disease (COPD) may raise the ... new large Canadian study reveals. The finding ... prescribed long-acting bronchodilators -- either anticholinergics (such as ... are commonly used to relieve the shortness of ...
(Date:5/21/2013)... News) -- Racial disparities exist in the treatment of ... States, according to a large new study. Although ... of their initial treatment, researchers found that blacks were ... in the early stages of the disease. Hispanics were ... stage 2 disease than white patients. "In our ...
(Date:5/21/2013)... ─ The negative effects of poorly controlled asthma ... urban schoolchildren has been confirmed in a new ... that missed sleep and school absences are important ... is the first to explore the associations between ... time, prospectively, using both objective and subjective ...
(Date:5/21/2013)... approach to obstructing the runaway inflammatory response implicated ... in a Phase IIa clinical trial, according to ... presented at the American Thoracic Society 2013 International ... New England Journal of Medicine . , The ... safety of the monoclonal antibody, dupilumab, in patients ...
(Date:5/21/2013)... Goderich, Ontario, CA (PRWEB) May 21, 2013 ... the fitness boot camp business Fit Body Boot ... Meltdown Challenge starting June 3rd at its Goderich fitness ... Fit Body Boot Camp’s 1,000 lb. Meltdown Challenge’s goal is ... total of 1,000 pounds in 28 days. The fee ...
Breaking Medicine News(10 mins):Health News:Certain COPD Meds Might Raise Heart Risks, Study Says 2Health News:Certain COPD Meds Might Raise Heart Risks, Study Says 3Health News:Racial Disparities Seen in U.S. Lung Cancer Treatment 2Health News:Asthma symptoms impair sleep quality and school performance in children 2Health News:Monoclonal antibody appears effective and safe in asthma Phase IIa trial 2Health News:Monoclonal antibody appears effective and safe in asthma Phase IIa trial 3Health News:Goderich Fitness Center Promotes 2nd Annual 1,000 lb. Meltdown Challenge to Fight Obesity With All Proceeds Raised Going to Local Charity 2Health News:Goderich Fitness Center Promotes 2nd Annual 1,000 lb. Meltdown Challenge to Fight Obesity With All Proceeds Raised Going to Local Charity 3
... 11 Wound Management,Technologies, Inc., (OTC Bulletin Board: ... potential acquisition of BioPharma Management Technologies, Inc.,a company ... pain,management products. "While we have been focusing ... products, we also have been working,to expand our ...
... Dec. 11 Barr Pharmaceuticals, Inc. (NYSE: ... Food and Drug Administration (FDA) has accepted for ... 7 Live Oral Vaccines Biologics License Application (BLA). ... development initiative and demonstrate the Company,s ability to ...
... research is declining sharply, more than 9 percent a year since ... of Pain . Pain research, as a result, now accounts ... Institutes of Health (NIH), despite the high prevalence of chronic pain ... government,s meager investment in pain research is seriously out of proportion ...
... are asking if cardiology patients receive intervention-type treatments, such as ... , In regions of the country where ... problems, patients may be receiving a treatment known as percutaneous ... to a study published online this week in the journal ...
... funding source to public health , ... Prevention today unveiled health reform recommendations to Congress that ... tackle the chronic diseases that are causing medical costs ... Under these proposals, federally funded insurance programs would provide ...
... CITY, Dec. 11 Genomma Lab Internacional,S.A.B. de ... a leading Mexican,over-the-counter ("OTC") pharmaceuticals and personal care ... personal hair care product line,Ma Evans. The ... campaign under,the brand name "Ma Evans Evolution". ...
Cached Medicine News:Health News:Wound Management Technologies, Inc. Announces Negotiations to Acquire BioPharma Management Technologies, Inc. 2Health News:Wound Management Technologies, Inc. Announces Negotiations to Acquire BioPharma Management Technologies, Inc. 3Health News:Barr's BLA for Adenovirus Type 4 and 7 Live Oral Vaccines Accepted for Filing by FDA 2Health News:Barr's BLA for Adenovirus Type 4 and 7 Live Oral Vaccines Accepted for Filing by FDA 3Health News:Barr's BLA for Adenovirus Type 4 and 7 Live Oral Vaccines Accepted for Filing by FDA 4Health News:Barr's BLA for Adenovirus Type 4 and 7 Live Oral Vaccines Accepted for Filing by FDA 5Health News:Study shows major pain research funding decline at NIH 2Health News:Study Asks: Are Physicians Overusing an Invasive Cardiac Treatment? 2Health News:Study Asks: Are Physicians Overusing an Invasive Cardiac Treatment? 3Health News:Study Asks: Are Physicians Overusing an Invasive Cardiac Treatment? 4Health News:Partnership for Prevention Offers Health Reform Recommendations to Congress 2Health News:Partnership for Prevention Offers Health Reform Recommendations to Congress 3Health News:Genomma Lab Announces the Successful Launch of the Ma Evans Brand 2
(Date:5/21/2013)... , May 21, 2013 ... report is available in its catalogue: ... and Reimbursement Scenario for Medical Devices in ...   Changing Regulatory ... the US Market   ...
(Date:5/21/2013)... STAAR Surgical Company (NASDAQ: STAA ... invasive ophthalmic products, today announced that it will participate ... recent financial results and business developments with investors and ... the 38 th Annual Deutsche Bank 2013 Healthcare ... Westin Waterfront Hotel on Wednesday, May 29, 2013 at ...
(Date:5/20/2013)... 2013   , ... ministers gather to address the large physical and economic ... disorders (MNDs) affect 700 million people annually and account ... ,Do You Mind?, helps patients, family members, ... play to collectively address MNDs , Today ...
Breaking Medicine Technology:Changing Regulatory and Reimbursement Scenario for Medical Devices in the US Market 2Changing Regulatory and Reimbursement Scenario for Medical Devices in the US Market 3Changing Regulatory and Reimbursement Scenario for Medical Devices in the US Market 4STAAR Surgical To Present At Upcoming Investor Conferences 2Research-based Pharmaceutical Industry Launches 'Do You Mind?' Campaign to Fight Mental and Neurological Disorders 2
... ALISO VIEJO, Calif. and STATE COLLEGE, Pa., Dec. 3 ... of an agreement to provide extended bioinformatics genomics services ... at Ambry. , (Logo: http://www.newscom.com/cgi-bin/prnh/20090428/LA06744LOGO ... team at Ambry has been providing genomics solutions on ...
... , DOYLESTOWN, Pa., ... Quigley Corporation, (Nasdaq: QGLY ) www.quigleyco.com announced ... opportunities to develop prescription pharmaceutical and OTC products and has ... primarily on the OTC/Personal Care marketplace, which may include but ...
Cached Medicine Technology:Ambry Genetics and SoftGenetics Form Exclusive Alliance for Extended Bioinformatics Support for Next Generation Sequencing Projects 2Ambry Genetics and SoftGenetics Form Exclusive Alliance for Extended Bioinformatics Support for Next Generation Sequencing Projects 3Quigley CEO, Ted Karkus, Announces Phase One of 2010 Strategic Plan; Karkus Reports that the Primary Focus will be on Leveraging its OTC Platform; Company Aggressively Seeking Product Acquisitions and Line Extensions which Leverage its Distribution 2Quigley CEO, Ted Karkus, Announces Phase One of 2010 Strategic Plan; Karkus Reports that the Primary Focus will be on Leveraging its OTC Platform; Company Aggressively Seeking Product Acquisitions and Line Extensions which Leverage its Distribution 3
... Array systems are fully automated ... fast turnaround of highly accurate ... drug monitoring (TDM) results. Using ... the easy-to-use Array® 360 performs ...
ELISA kit for detection of Rheumatoid Factor....
... create tired, dry eyes. With ACUVUE OASYS IN, ... challenging environments can make your eyes feel tired ... a computer can leave your eyes craving moisture. ... PLUS Brand Contact Lenses. It will almost ...
... Better. Introducing Disposable Bimanuals. With the ... need for quality single-use bimanuals. Oasis meets ... NEW disposable bimanuals. Single use bimanuals decrease ... time, they encompass all the advantages of ...
Medicine Products: