Navigation Links
New therapy found for rare lung disorder
Date:3/16/2011

ing lung function in women with LAM."

McCormack says LAM cells isolated from lung lesions have TSC mutations and exhibit activation of a key sirolimus-sensitive growth pathway. When exposed to the drug in culture, the growth of LAM cells is stopped.

Experiments in TSC animal models have also demonstrated that sirolimus shrinks tumors in the liver and kidneys.

The MILES study was conducted within the National Institutes of Health (NIH)-supported Rare Lung Diseases Consortium, led by UC and Cincinnati Children's physician and pulmonary biologist Bruce Trapnell, MD, and co-directed by McCormack, and involved 13 institutions from around the world. Data was reported using Internet-based systems connected to a centralized, Internet-based data coordinating center headed by Jeffrey Krischer, MD, at the University of South Florida, Tampa.

"The trial included a screening visit and a year-long double blind, placebo-controlled treatment period, followed by a year of observation," says McCormack.

All eligible participants were female, aged 18 years or older and had a confirmed diagnosis of LAM with abnormal lung function.

Patients meeting the criteria were randomly assigned to either receive an initial dose of oral sirolimus at 2 milligrams per day or a matched placebo, and sirolimus levels were measured at each follow-up visit. Results were revealed only to an independent medical monitor who made dosing recommendations to maintain serum levels within a pre-specified target range.

A total of 89 patients with LAM were enrolled in the United States, Canada and Japan. Patients underwent baseline lung function testing, and lung function and exercise outcomes were measured over the course of six visits in the first year. Participants were also given questionnaires to determine how their symptoms changed throughout the course of the study.

Researchers found that sirolimus stabilized lung function and was associ
'/>"/>

Contact: Katie Pence
katie.pence@uc.edu
513-558-4561
University of Cincinnati Academic Health Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Sirolimus therapy alleviates symptoms of lung disease LAM
2. Research study explores gene therapy treatment to reduce symptoms of Parkinsons disease
3. University Hospitals Case Medical Center testing innovative heat therapy for premature ejaculation
4. Ohio State study: Targeted ovarian cancer therapy not cost-effective
5. Stroke patients benefit from family involvement in exercise therapy
6. Extra Tests Not a Deterrent to Experimental Cancer Therapy
7. Gene Therapy Against HIV Not a Proven Cure, Experts Say
8. WSU researcher creates patented personalized therapy that causes cancer cells to kill themselves
9. BUSM study shows chemoradiotherapy prior to surgery improves survival
10. Fish oil fights weight loss due to chemotherapy
11. Lack of health insurance limits hepatitis C patients access to latest antiviral therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/1/2015)... ... 2015 , ... The Collaborative for Children and Families (CCF) announced that it ... allow CCF to improve quality of care and save costs for the child welfare ... many changes in New York’s Medicaid system. Experts agree that children need thorough solutions ...
(Date:7/1/2015)... (PRWEB) , ... July 01, 2015 , ... ... sales training leaders Lora Posey (Manager, National Sales Training and Development) and Chuck ... Educators Network (LTEN) Conference in Phoenix, AZ. LTEN brings together learning and development ...
(Date:7/1/2015)... ... 01, 2015 , ... As if mood swings, cramps and child labor weren’t ... women: leg pain. Northeast Houston Vein Center is offering tips on the treatment options ... disease, is underdiagnosed and often overlooked. Many women experience the tiredness, achiness, restless legs, ...
(Date:7/1/2015)... , ... July 01, 2015 , ... ... Task Force, contributing to newly released white paper: “Pro-actively Identifying the High-Cost Patient ... published July 1st and is available at: http://www.hcttf.org/resouces-tools . , The Healthcare ...
(Date:7/1/2015)... ... July 01, 2015 , ... ... is helping families get ready for Independence Day celebrations with new takes on ... and versatile options are perfect for any summertime get together. , “Celebrating with ...
Breaking Medicine News(10 mins):Health News:The Collaborative for Children and Families Receives a Grant From The New York Community Trust to Build Capacity for Comprehensive Child Welfare 2Health News:The Collaborative for Children and Families Receives a Grant From The New York Community Trust to Build Capacity for Comprehensive Child Welfare 3Health News:Mission Pharmacal Company: Alamo Pharma Services' Training Leaders Take Steps to Further Expand Capabilities for Mission Pharmacal and Other Clients 2Health News:Mission Pharmacal Company: Alamo Pharma Services' Training Leaders Take Steps to Further Expand Capabilities for Mission Pharmacal and Other Clients 3Health News:Mission Pharmacal Company: Alamo Pharma Services' Training Leaders Take Steps to Further Expand Capabilities for Mission Pharmacal and Other Clients 4Health News:Northeast Houston Vein Center Offers Tips for Women with Leg Pain 2Health News:Northeast Houston Vein Center Offers Tips for Women with Leg Pain 3Health News:A Population Based Approach to Pay for Value: RowdMap, Inc. Contributes to Health Care Transformation Task Force White Paper 2Health News:A Population Based Approach to Pay for Value: RowdMap, Inc. Contributes to Health Care Transformation Task Force White Paper 3Health News:Boar’s Head Helps Craft a Delicious Independence Day 2Health News:Boar’s Head Helps Craft a Delicious Independence Day 3
... Nov. 18 Just in time for ... Web site http://www.ShopForCancerCures.org to,benefit cancer ... http://www.fhcrc.org ) and 10 other world-class cancer ... http://www.cancerresearchalliance.org ). A portion of,each purchase on ...
... Holiday Season , , ROSEMONT, Ill., Nov. ... your bags, then take out half." This refers to the ... our trips. Now, even more travelers are echoing that line, especially, ... luggage. However, if you are one of those people who cannot ...
... postmenopausal women, study says , , TUESDAY, Nov. 18 (HealthDay ... diet and exercise affect a women,s chance of breast ... , Researchers at the University of Texas at ... to mTOR, a molecule that integrates energy balance with ...
... study found it was better than corn oil during ... News) -- Women whose mothers consumed canola oil during ... breast cancer than those whose mothers consumed corn oil, ... lactating mice a diet high in either corn oil, ...
... (BWF) has selected Emory University for a $2.5 million, ... expertise in research and teaching will bridge laboratory and ... one of three new BWF programs funded nationally within ... The other two programs will be located at the ...
... program to improve exercise and diet led to ... physical function among older long-term cancer survivors in ... Wellness) trial, according to Wendy Demark-Wahnefried, Ph.D., from ... Center,s Department of Behavioral Science. The data are ...
Cached Medicine News:Health News:Fred Hutchinson Cancer Research Center Benefits From Shopping Site 2Health News:Fred Hutchinson Cancer Research Center Benefits From Shopping Site 3Health News:Lug Your Luggage Safely 2Health News:Lug Your Luggage Safely 3Health News:Diet, Exercise May Modify Breast Cancer Risks 2Health News:Canola Oil Consumed During Pregnancy Lowers Breast Cancer Risk for Offspring 2Health News:Burroughs Wellcome Fund award creates new Ph.D. path linking laboratory and population sciences 2Health News:Burroughs Wellcome Fund award creates new Ph.D. path linking laboratory and population sciences 3Health News:Home-based diet and exercise intervention improves elderly cancer survivors' physical function 2
(Date:7/1/2015)... , July 1, 2015 Prismic Pharmaceuticals, Inc., ... FDA-regulated medical foods, today announced the election of ... to its Board of Directors. Commenting ... Peter Moriarty , Chairman and CEO of Prismic, ... and Martin Simonetti have accepted our invitation ...
(Date:7/1/2015)... YORK, Pa. , July 1, 2015  Unilife ... developer, manufacturer and supplier of injectable drug delivery systems, ... been amended as of June 30, 2015. This amendment ... least $20 million in cash receipts from customers during ... no other adjustments to any of the terms of ...
(Date:7/1/2015)... July 1, 2015  Imprimis Pharmaceuticals, Inc. (NASDAQ: ... the development and commercialization of proprietary compounded drug ... The Nasdaq stock market closing bell on Thursday, ... success of its Go Dropless™ campaign since its ... procedures are performed annually in the U.S. and ...
Breaking Medicine Technology:Joseph Krivulka and Martin Simonetti Join Board of Prismic Pharmaceuticals 2Unilife and OrbiMed Amend Debt Financing Agreement 2Unilife and OrbiMed Amend Debt Financing Agreement 3Imprimis Pharmaceuticals to Ring The Nasdaq Stock Market Closing Bell 2Imprimis Pharmaceuticals to Ring The Nasdaq Stock Market Closing Bell 3Imprimis Pharmaceuticals to Ring The Nasdaq Stock Market Closing Bell 4
... and health care payer and provider organizations convened at the "Selling Pharmaceuticals in 2015" forum in ... drugs on price, features and benefits with a new model that focuses on quantifying and communicating total ... ... , ...
... platform technology designed to standardize hyperthermic perfusion treatments, today announced the appointment of Alan Hirschman , PhD to its Board of Directors. , ... , ... ... ...
Cached Medicine Technology:Drug Makers Discuss New Ways to Trim Health Care Costs at ZS Associates and eyeforpharma Forum 2Drug Makers Discuss New Ways to Trim Health Care Costs at ZS Associates and eyeforpharma Forum 3Drug Makers Discuss New Ways to Trim Health Care Costs at ZS Associates and eyeforpharma Forum 4Drug Makers Discuss New Ways to Trim Health Care Costs at ZS Associates and eyeforpharma Forum 5Drug Makers Discuss New Ways to Trim Health Care Costs at ZS Associates and eyeforpharma Forum 6Drug Makers Discuss New Ways to Trim Health Care Costs at ZS Associates and eyeforpharma Forum 7Drug Makers Discuss New Ways to Trim Health Care Costs at ZS Associates and eyeforpharma Forum 8ThermalTherapeutic Systems, Inc. Announces the Addition of Former MEDRAD Executive Alan Hirschman, PhD to the Board of Directors 2ThermalTherapeutic Systems, Inc. Announces the Addition of Former MEDRAD Executive Alan Hirschman, PhD to the Board of Directors 3
Mounted on a sturdy, molded headband,the Classic has a fully adjustable crown,strap and cushioning that adds to,your comfort....
Mounted on an extremely lightweight,and flexible cotton headband, the,Halogen III Sport adjusts around the head,and the crown strap for a comfortable and secure fit....
Mounted on a fully adjustable molded,headband with crown strap and comfort,cushions, the sturdy Halogen III Classic is,lightweight, comfortable and durable....
Mounted on a remarkably lightweight and,flexible cotton headband with crown strap,the Sport is fully adjustable....
Medicine Products: