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New therapies increase survival rates in post-transplant liver cancer patients
Date:3/25/2010

effects were due to a direct impact of the drug on tumor or more on liver transplant in general, the research team conducted a similar analysis on non-HCC patients. While anti-CD25 induction was again associated with a trend toward improved survival, sirolimus showed a trend toward lower rates of survival in non-HCC recipients, confirming the specificity of its beneficial impact to cancer patients.

"Of all protocols, sirolimus-based immunosuppression was the only one associated with an improved post-transplantation survival specific to HCC patients, further reinforcing the clinical evidence of its anti-cancer properties," Dr. Toso concluded. "The use of anti-CD25 antibodies demonstrated similar trends to improved survival in both HCC and non-HCC patients. These observations, together with previous reports combining anti-CD25 antibody induction and delayed introduction of CNIs, speak in favor of the use of this drug after liver transplantation in general."

He adds, "Like any potent immunosuppressive drug, sirolimus is linked to a potential for development of numerous side effects. In general however, we believe that these side effects are relatively minor and easy to manage, and that the data revealed by the present study justify a broader use of protocols including sirolimus after liver transplantation for patients with HCC."

In another recent study on hepatocellular carcinoma, researchers from Seoul Veterans Hospital compared hepatic resection (HR) to radiofrequency ablation (RFA) to treat patients with very early-stage HCC, defined as asymptomatic solitary HCC less than 2cm. Very early stage HCC can be an ideal indication for HR because of the low potential risk of microscopic seeding. According to AASLD guidelines, HR is the treatment of choice for patients with very early stage HCC.

Researchers compared HR and percutaneous RFA for the treatment of compensated cirrhotic patients with very early stage HCC using a Markov model
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Contact: Dawn Peters
medicalnews@wiley.com
781-388-8408
Wiley-Blackwell
Source:Eurekalert

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