Navigation Links
New therapies and gene target advance the treatment and understanding of hard-to-treat leukemias
Date:12/6/2010

dysplastic syndrome, myeloproliferative neoplasms, and acute myeloid leukemia.

A team of scientists at the Taussig Cancer Institute at the Cleveland Clinic in Ohio and Dana-Farber Cancer Institute at Harvard University initiated several specialized experiments on leukemic cancer cells carrying TET2 gene mutations. TET2 mutations occurred throughout the entire TET2 gene and led to its inactivation. Functional studies showed that the TET2 mutations likely alter epigenetic regulation.

Epigenetic alterations are a form of chemical modification of the DNA strand that naturally occurs during normal tissue maturation, but is disturbed in cancer. One key epigenetic mechanism is the methylation of cytosines (one of the four building blocks of DNA), which effectively blocks or "silences" particular genes.

Experimental results demonstrate that the TET2 gene alters the conversion of 5-methylcytosine to 5-hydroxymethylcytosine, which likely in turn affects the silencing function of 5- methylcytosine. TET2 mutations, or experimentally decreased TET2 levels, resulted in lower hydroxymethylcytosine levels and perturbed maturation of bone marrow stem cells.

"The process of methylation or 'silencing' of genes can be altered in disease or through application of epigenetic drugs. Identification of the variant of cytosine, 5-hydroxymethylcytosine, introduces a new mechanism of epigenetic regulation that has never been explored," said senior study author Jaroslaw P. Maciejewski, MD, PhD, FACP, Chairman, Department of Translational Hematology and Oncology Research, Taussig Cancer Institute at the Cleveland Clinic in Ohio. "The mutation in TET2 is an important, common mutation associated with leukemia that affects epigenetics, and now we are closer to deciphering the functional consequences of this mutation. It is likely that 5-hydroxymethylcytosine levels may become a disease biomarker and possibly molecular target for the development of new therapies.
'/>"/>

Contact: Lindsey Love
llove@hematology.org
540-538-9326
American Society of Hematology
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9 10

Related medicine news :

1. MSU researcher linking breast cancer patients with alternative therapies
2. Notch-blocking drugs kill brain cancer stem cells, yet multiple therapies may be needed
3. ReportsandReports : The Gastrointestinal Market Outlook to 2014: Market Dynamics, Competitive Landscape, Emerging Therapies
4. NIH/NHLBI-funded PACT Group Announces the Renewal of Production Assistance for Cellular Therapies (PACT)
5. ACCORD: Intensive BP, combined lipid therapies do not help adults with diabetes
6. Intense Cholesterol, Blood Pressure Therapies Dont Help Type 2 Diabetics
7. Study evaluates costs and benefits associated with new colon cancer therapies
8. New therapies increase survival rates in post-transplant liver cancer patients
9. Survival in metastatic breast cancer patients is improving: targeted therapies have contributed
10. Molecular discovery points to new therapies for brain tumors
11. Ovarian cancer study offers vital clues for new therapies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2014)... (April 18, 2014) ― A new study in the ... patterns in health-related Google searches reveals a recurring pattern ... , Investigators from San Diego State University, ... Monday Campaigns, analyzed "healthy" Google searches (searches that included ... diet") originating in the U.S. from 2005 to 2012. ...
(Date:4/17/2014)... identified the first genetic variant specifically associated with ... for around 10-15 per cent of all breast ... the breast cancer sub-type, called invasive lobular carcinoma, ... of this particular kind of breast cancer, which ... published today (Thursday) in the journal PloS ...
(Date:4/17/2014)... at the University of California, San Diego School of ... who have suffered a recent major loss are more ... adults. , The study is published in this month,s ... . , Because compassionate behaviors are associated with better ... offer insights into ways to improve the outcomes of ...
(Date:4/17/2014)... 2014U.S. military personnel who served in Iraq and ... brain injury (TBI) were compared to military personnel ... reasons. Differences in measures of overall disability, cognitive ... injury are reported in an article in ... Mary Ann Liebert, Inc., publishers. The article is ...
(Date:4/17/2014)... By discovering a new mechanism that allows blood ... at UC Irvine and the Salk Institute have opened ... prevent stroke-induced brain damage. , A complex and devastating ... and primary reason for disability in the U.S. The ... lets blood-borne material into the brain, causing the permanent ...
Breaking Medicine News(10 mins):Health News:New research shows people are thinking about their health early in the week 2Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 2Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 3Health News:The ilk of human kindness 2Health News:Long-term effects of battle-related 'blast plus impact' concussive TBI in US military 2Health News:Study IDs new cause of brain bleeding immediately after stroke 2
... lead to better treatment when problems occur , , THURSDAY, June ... -- the brain,s "smell center" -- may change in size ... reports. , In this study, researchers at the University ... sense of smell. At the start of the study, the ...
... to announce that KARE 11 TV has named the ... Over the years, Twin Cities based KARE TV,s Eleven ... including 2008) community,volunteers. The story of each recipient is ... volunteers (including three pairs of,volunteers) have been honored with ...
... Long-Term Progress, DEERFIELD, Ill., June 19 ... today released its 2007 Sustainability Report -- ... 2007 social,economic and environmental performance. The report ... the company,s sustainability,priorities announced in 2007. The ...
... be the culprit, experts say , , THURSDAY, June 19 (HealthDay ... alive and relatively healthy for years, even decades. But studies ... long-term survivors: increased odds for heart attack and stroke. , ... or the drugs used to treat it, said Dr. Steven ...
... of Medicine will be home to the nation,s sole ... for gene therapy research with a three-year, $3 million ... The program is directed by Kenneth Cornetta, M.D, Joe ... Genetics and professor of medicine and of microbiology and ...
... database, AUBURN HILLS, Mich., June 19 ... on-demand software for the manufacturing,enterprise, today announced ... using Plexus Online to facilitate collaboration,coordination and ... academic., (Logo: http://www.newscom.com/cgi-bin/prnh/20070627/CLW071LOGO ), ...
Cached Medicine News:Health News:Brain's Olfactory Bulb Grows With Sense of Smell 2Health News:Courage Center Honored With KARE TV's 2008 Eleven Who Care Agency of Distinction 2Health News:Baxter Releases Ninth Annual Sustainability Report 2Health News:Baxter Releases Ninth Annual Sustainability Report 3Health News:Heart Risks Emerging in People With HIV 2Health News:Heart Risks Emerging in People With HIV 3Health News:Indiana University to host national biorepository for gene therapy 2Health News:Plexus Online Enables Business-Government-Academic Collaboration for Advanced Technology Institute 2Health News:Plexus Online Enables Business-Government-Academic Collaboration for Advanced Technology Institute 3Health News:Plexus Online Enables Business-Government-Academic Collaboration for Advanced Technology Institute 4
(Date:1/15/2014)... GENEVA, Ill. , Jan. 15, 2014 The ... a Medical Fitness Center by the Medical Fitness Association, ... centers to achieve their full potential. The Cadence Fitness ... in the western suburbs and second in the Chicagoland ...
(Date:1/15/2014)... 15, 2014 Reportlinker.com announces that a ... its catalogue: Insulin ... http://www.reportlinker.com/p01957812/Insulin-Pump-Market--Forecast-–-Worldwide-Analysis.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Medical_Equipment_and_Supply ... Insulin Pumps are gaining strong ...
(Date:1/15/2014)... Jan. 15, 2014  Valeant Pharmaceuticals International, Inc. (NYSE: ... applicable waiting period under the Hart-Scott-Rodino Antitrust Improvements Act ... tender offer by its indirect wholly-owned subsidiary, Sapphire Subsidiary ... common stock of Solta Medical, Inc. (NASDAQ: ...
Breaking Medicine Technology:Cadence Fitness & Health Center Certified as Medical Fitness Facility 2Cadence Fitness & Health Center Certified as Medical Fitness Facility 3Insulin Pump Market & Forecast - Worldwide Analysis 2Insulin Pump Market & Forecast - Worldwide Analysis 3Insulin Pump Market & Forecast - Worldwide Analysis 4Insulin Pump Market & Forecast - Worldwide Analysis 5Insulin Pump Market & Forecast - Worldwide Analysis 6Insulin Pump Market & Forecast - Worldwide Analysis 7Insulin Pump Market & Forecast - Worldwide Analysis 8Insulin Pump Market & Forecast - Worldwide Analysis 9Insulin Pump Market & Forecast - Worldwide Analysis 10Insulin Pump Market & Forecast - Worldwide Analysis 11Insulin Pump Market & Forecast - Worldwide Analysis 12Insulin Pump Market & Forecast - Worldwide Analysis 13Insulin Pump Market & Forecast - Worldwide Analysis 14Insulin Pump Market & Forecast - Worldwide Analysis 15Insulin Pump Market & Forecast - Worldwide Analysis 16Insulin Pump Market & Forecast - Worldwide Analysis 17Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 2Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 3
0.6mm Tip x10mm Shaft, Straight Shaft, 90 Degree Hook at Tip; overall length 120mm; in Titianium....
... SURPASS Perfusion Catheter is indicated ... stenotic portion of a coronary ... for the purpose of improving ... Catheters are also designed to ...
16mm from Mid-screw to Tips, blunt tips; overall length 110mm; Stainless Steel...
16mm from Mid-Screw to Blunt Tips, Gently Curved Blades; overall length 120mm; Stainless Steel...
Medicine Products: