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New therapies and gene target advance the treatment and understanding of hard-to-treat leukemias
Date:12/6/2010

atinib, show significant differences in outcomes between the three different groups after three years of follow-up. The researchers found that overall survival reached 25 percent in the pre-imatinib arm, 34 percent in the late-imatinib arm, and 48 percent in the early-imatinib arm. Event-free survival was 19 percent in the pre-imatinib arm, 29 percent in the late-imatinib arm, and 35 percent in the early-imatinib arm. Additionally, relapse-free survival reached 36 percent, 45 percent, and 62 percent respectively.

Prior to the introduction and availability of imatinib, only 28 percent of patients went on to receive an allogeneic stem cell transplant per the study protocol. In these pre-imatinib patients, five-year overall survival was 40 percent for those patients who received an allogeneic stem cell transplant compared with 19 percent for non-transplanted patients. Of patients in the "late" and "early" arms who received imatinib, 44 percent were able to undergo the allogeneic stem cell transplant. Three-year overall survival was 59 percent for these transplant patients compared with 28 percent for those who did not receive a transplant.

"The Philadelphia chromosome is the single most common chromosome abnormality for adults with ALL, and therefore it is important to know that a targeted therapy like imatinib can help improve outcomes in these patients," said lead study author Adele K. Fielding, MBBS, PhD, FRCPath, FRCP, Senior Lecturer, University College London. "These study results demonstrate for the first time that there is a long-term survival advantage of being treated with imatinib earlier in the treatment protocol."

Dr. Fielding will present this study in an oral presentation on Monday, December 6, at 7:00 a.m. in Room 311 ABCD.

Excellent Outcomes at 3 Years With Nilotinib 800 mg Daily in Early Chronic Phase, Ph+ Chronic Myeloid Leukemia (CML): Results of a Phase 2 GIMEMA CML WP Clinical Trial

Contact: Lindsey Love
llove@hematology.org
540-538-9326
American Society of Hematology
Source:Eurekalert

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