Navigation Links
New therapeutic target for most common solid cancer in childhood?
Date:2/15/2010
A team of researchers, led by Patrick Mehlen, at Universit de Lyon, France, has identified the protein NT-3 and the cell-surface molecule to which it binds (TrkC) as potential therapeutic targets for the treatment of neuroblastoma the most frequent solid tumor in young children by studying human neuroblastoma cells in vitro and after xenotransplantation into mice and chicks.
In the study, NT-3 was found to be expressed at increased levels in aggressive human neuroblastomas and to block the ability of TrkC to induce tumor cell death by a process known as apoptosis. In vitro analysis of human neuroblastoma cell lines indicated that both decreasing NT-3 expression and culturing in the presence of an antibody that blocked NT-3 binding to TrkC triggered the cells to undergo apoptosis. More importantly, blocking the NT-3/TrkC interaction inhibited tumor growth and metastasis in both a chick and a mouse xenograft model of neuroblastoma. The authors therefore suggest that disrupting the NT-3/TrkC interaction might provide a new approach to treating neuroblastoma, a form of cancer for which treatment options are currently limited.
'/>"/>
| Contact: Karen Honey press_releases@the-jci.org 215-573-1850 Journal of Clinical Investigation Source:Eurekalert |
Related medicine news :
1. Northwest Biotherapeutics Inc. Appoints Market Media Connect as Communications Agency of Record
2. Echo Therapeutics Provides Business Update
3. SaltWorks Launches Two All-Natural Bath Salt Lines Featuring Therapeutic Salt from the Dead Sea
4. Reportlinker Adds The Future of Respiratory Diseases Therapeutics - Market Forecasts to 2015, Competitive Benchmarking, Product Pipeline and Deals Analysis
5. Reportlinker Adds The Future of Cardiovascular Diseases Therapeutics - Market Forecasts to 2015, Competitive Benchmarking, Product Pipeline and Deals Analysis
6. Reportlinker Adds The Future of Autoimmune Diseases Therapeutics - Market Forecasts to 2015, Competitive Benchmarking, Product Pipeline and Deals Analysis
7. Anesiva Stockholders Approved Merger With Arcion Therapeutics but Merger Remains Contingent on Other Closing Conditions
8. Osseon Therapeutics, Inc. Announces it has Received Canadian Medical Device Licenses From Health Canada
9. Development of Newer Therapies to Treat Lifestyle Disorders and Reduce the Risk of Co-morbidities is Key to the Expansion of the European Lifestyle Disorders Therapeutics Market, Says Frost & Sullivan
10. Reportlinker Adds The Future of Central Nervous System Diseases Therapeutics - Market Forecasts to 2015, Competitive Benchmarking, Product Pipeline and Deals Analysis
11. Cell Therapeutics, Inc. (CTI) Piper Jaffray Presentation to be Webcast
Post Your Comments:
(Date:5/22/2013)... -- Fish oil supplements could help reduce the ... The supplements, also known as omega-3 ... adiponectin that,s linked to insulin sensitivity, Harvard researchers ... bloodstream have also been linked to a lower ... studies found fish oil increased circulating adiponectin, whether ...
(Date:5/22/2013)... A 2012 survey of internal medicine residents at Massachusetts ... teaching hospitals found that more than half rated ... substance use disorders as fair or poor. Significant numbers ... similar to surveys of practicing physicians. In response to ... Substance Abuse , the MGH has increased residents, training ...
(Date:5/22/2013)... depression have on his young son or daughter? When fathers ... their children benefit, said a University of Illinois study. , ... to be able to attend to the child,s emotional state, ... notice whether he is getting frustrated or needs help. Depressed ... U of I professor of human development. , But if ...
(Date:5/22/2013)... IL A new study suggests that disturbed ... of depression and greater uncertainly about future success. ... and teachers appears to have a protective effect. ... significantly associated with depressed mood and greater uncertainty ... from parents and from teachers were associated with ...
(Date:5/22/2013)... to the "power plants" that make energy to keep ... preventing emergence of the drug-resistant forms of cancer ... That,s the conclusion of a new study published in ... Shana Kelley and colleagues explain that doxorubicin and other ... inside the nucleus of cancer cells. Cancer cells divide ...
Breaking Medicine News(10 mins):Health News:Fish Oil Pills Might Cut Diabetes Risk, Researchers Say 2Health News:Survey points out deficiencies in addictions training for medical residents 2Health News:Survey points out deficiencies in addictions training for medical residents 3Health News:Survey points out deficiencies in addictions training for medical residents 4Health News:Good marriage can buffer effects of dad's depression on young children 2Health News:Parent and teacher support protects teens from sleep problems and depression 2[0] Fish Oil Pills Might Cut Diabetes Risk, Researchers Say[0] Survey points out deficiencies in addictions training for medical residents[0] Good marriage can buffer effects of dad's depression on young children[0] Parent and teacher support protects teens from sleep problems and depression[0] Overcoming resistance to anti-cancer drugs by targeting cell 'powerhouses'
... of Psychiatry at Case Western Reserve University School of Medicine ... Institute of Mental Health (NIMH) for the long-term study of ... NIMH, one of the National Institutes of Health (NIH), funds ... which 707 children between the ages of six and 12 ...
... By Maryann Mott HealthDay Reporter , THURSDAY, ... twice before snuggling in bed at night with Fido or ... issue of the public health journal Emerging Infectious Diseases ... that cause mild to life-threatening illness in people. Of ...
... HealthDay Reporter , THURSDAY, Jan. 20 (HealthDay ... greatly increases the chances of dying, new research ... analysis, of previously published studies that looked at ... Six of seven studies found pre-existing diabetes was ...
... (HealthDay News) -- Many young American couples can,t agree on ... a new study shows. Oregon State University researchers analyzed ... 18 to 25. In 40 percent of those couples, one ... the other partner said there was no such deal. ...
... paper published Jan. 21 in the journal Science , ... Blossom Damania, PhD, has shown for the first time that ... a key molecule involved in the human immune response. ... Kenan, Jr. Distinguished Professor, Jenny Ting, PhD. First ...
... Ky. Healthcare workers can most directly affect quality of ... helping manage symptoms such as pain, lack of energy, shortness ... a study recently published in the journal Oncology Nursing ... or the degree to which a symptom bothers a person, ...
Cached Medicine News:Health News:Case Western Reserve receives $7.8M to study manic symptoms in children 2Health News:Case Western Reserve receives $7.8M to study manic symptoms in children 3Health News:Pets May Pass Illnesses to Owners 2Health News:Pets May Pass Illnesses to Owners 3Health News:Breast Cancer Patients With Diabetes May Fare Worse 2Health News:Breast Cancer Patients With Diabetes May Fare Worse 3Health News:Young Couples Often Disagree About Monogamy, Study Finds 2Health News:Viral protein mimic keeps immune system quiet 2Health News:Controlling symptoms can lead to improved quality of life for end-of-life patients 2Case Western Reserve receives $7.8M to study manic symptoms in childrenPets May Pass Illnesses to OwnersBreast Cancer Patients With Diabetes May Fare WorseYoung Couples Often Disagree About Monogamy, Study FindsViral protein mimic keeps immune system quietControlling symptoms can lead to improved quality of life for end-of-life patients
(Date:5/22/2013)... May 22, 2013 Healthcare providers are ... content management (ECM) solution, for a ... System . These organizations identified enterprise content ... will use OnBase to optimize their Meditech ... (Logo: http://photos.prnewswire.com/prnh/20090130/65710LOGO ) ...
(Date:5/22/2013)... , May 22, 2013 STEPh, Inc., a ... the launch of their web site ( http://www.stephreports.com ... About STEPh Reports STEPh ... Each STEPh Report assesses the competitive ... projected launch year, company, and specific key issues. STEPh ...
(Date:5/22/2013)... 22, 2013 Life Line Screening (LLS), ... today the creation of a unique partnership with ... MCM is a population health management organization. LLS ... of clients. These important expanded services will help MCM ... Effective prevention reduces cost of care when individuals are ...
Breaking Medicine Technology:Three New Health Systems Integrate Hyland Software's OnBase with Meditech Hospital Information System 2Three New Health Systems Integrate Hyland Software's OnBase with Meditech Hospital Information System 3Scientific and Technical Evaluation of Pharmaceuticals, Inc. [STEPh, Inc.], Launches New Competitive Intelligence Web Site 2Life Line Screening and MCM Solutions for Better Health Announce New Partnership 2[0] Three New Health Systems Integrate Hyland Software's OnBase with Meditech Hospital Information System[0] Scientific and Technical Evaluation of Pharmaceuticals, Inc. [STEPh, Inc.], Launches New Competitive Intelligence Web Site[0] Life Line Screening and MCM Solutions for Better Health Announce New Partnership
... a Deadly ... but Vaccine-Preventable Disease, WASHINGTON, Oct. 16 Parents ... its national,educational campaign "Silence the Sounds of Pertussis" with actress ... about the dangers of pertussis and alerts,parents to the need ...
... Specialists Meet for First Time to Discuss,Joint Research ... LAFAYETTE, Ind., Oct. 16 In what ... United States and the United,Kingdom, animal and human ... to effective treatments for deadly diseases that affect ...
Cached Medicine Technology:Actress and New Mom Keri Russell Joins PKIDs to launch 'Silence the Sounds of Pertussis' Campaign 2Actress and New Mom Keri Russell Joins PKIDs to launch 'Silence the Sounds of Pertussis' Campaign 3Man's Best Friend May Open Door to Understanding Fibrotic Lung Disease in Human and Animal Populations 2Man's Best Friend May Open Door to Understanding Fibrotic Lung Disease in Human and Animal Populations 3Man's Best Friend May Open Door to Understanding Fibrotic Lung Disease in Human and Animal Populations 4Man's Best Friend May Open Door to Understanding Fibrotic Lung Disease in Human and Animal Populations 5... the highest g-force ever. But optimal productivity ... Optima MAX combines maximum force, capacity, and ... that's worlds apart from any other system. ... enhanced efficiency, Optima takes productivity to the ...
... generating 694,000 x g at ... Beckman Coulter's Optima L-90K Ultracentrifuge ... separations in less time. This ... a broad range of superb ...
... With the ability to provide a simple, ... in lipemic samples), the Airfuge CLS delivers ... can be cleaned in 10 minutes, eliminating ... tabletop centrifuge: Reaches top speed in as ...
The Dimension RxL Max is an integrated chemistry system and is the most powerful and technologically advanced Dimension analyze with new standard for excellence in clinical diagnostics. Simply put, t...
Medicine Products:| Copyright © 2003-2012 Bio-Medicine. All rights reserved. ABOUT | CONTACT US | DISCLAIMER | PRIVACY POLICY | TERMS AND CONDITIONS |  |