Navigation Links
New therapeutic target for lung cancer
Date:3/31/2011

A new therapeutic target for lung cancer has been discovered by researchers at Seoul National University. It was found that a variant of the protein AIMP2 is highly expressed in lung cancer cells and also that patients demonstrating high expression of this variant show lower survival. The study is published on March 31 in the open-access journal PLoS Genetics.

Lung cancer is one of the world's most common cancers and a leading cause of death resulting from cancer. Despite treatment with a combination of surgery, radiation and drugs, the survival rate for patients has not drastically improved over the past few decades. It had previously been shown that the protein AIMP2 acted as a tumor-suppressor by interacting with another oncosuppressor, p53. However, whether AIMP2 was indeed pathologically linked to human cancer had not been definitively proved. This investigation discovered that a variant of AIMP2 is highly expressed in human lung cancer cells. AIMP2-DX2 compromises the tumor-suppressing activity of AIMP2 by competitively binding to p53. It was also shown that suppression of AIMP2-DX2 slowed tumor growth, suggesting that this could be an exciting new therapeutic target.

New innovative therapies are important not only because of the high mortality rate associated with lung cancer, but because the majority of the drugs are cytotoxic, causing many adverse effects. These findings could create an opportunity to develop new innovative cancer drugs, as well as presenting a new target that could also be applied to other cancers.


'/>"/>

Contact: Sunghoon Kim
sungkim@snu.ac.kr
822-880-8180
Public Library of Science
Source:Eurekalert

0

GOOD

Page: 1

Related medicine news :

1. McCain gives $5 million to St. Michael’s Hospital for therapeutic endoscopy
2. Researchers discover possible biomarker and therapeutic target for melanoma
3. Study identifies therapeutic target for liver cancer and predictive biomarker of response
4. Therapeutic lifestyle changes as useful as drugs in improving mental health
5. Mayo Clinic researchers confirm value of therapeutic hypothermia after cardiac arrest
6. Study compares balanced propofol sedation with conventional sedation for therapeutic GI endoscopic procedures
7. Save messengers -- modified mRNAs open up new therapeutic possibilities
8. Transplanted human placenta-derived stem cells show therapeutic potential in stroke models
9. Optimizing patient outcomes after therapeutic hypothermia for traumatic brain injury
10. Does Club Drug Ecstasy Have Therapeutic Value?
11. Autism Consortium 2010 Symposium: New therapeutics focus, family resource guide announced
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2013)... Los Angeles, CA (PRWEB) May 22, 2013 ... board, The J. M. Smucker Company, and Danny ... Awards yesterday at the GS1 General Assembly and Global ... Mr. Smucker and Mr. Wegman were recognized for their ... Standards - the most broadly used supply chain standards ...
(Date:5/22/2013)... report these findings in the current online edition ... pan-European study could open up new possibilities of ... which tackle diseases before the patient,s nervous system ... group of genetic diseases of the cerebellum and ... have limited control of their muscles. They also ...
(Date:5/22/2013)... new guidelines the first in more than 35 ... for surgical patients. The recommendations, based on a lengthy ... (JHH), can potentially save the medical center more than ... , A report on the research that led up ... Anesthesiology , suggests millions of dollars a year ...
(Date:5/22/2013)... Toppik and Bosley hair fibers, two hair loss concealer products ... hair. Hair loss treatments can be a lengthy process. In ... waiting period, one can use these hair loss concealers. They ... surgery in general. , Bosley and Toppik Hair Thickening ... eliminate the appearance of balding and thinning hair. It is ...
(Date:5/22/2013)... NC (PRWEB) May 22, 2013 The 2013 ... (DSM-5) is the largest change to hit the field ... Jung Center is will help prepare for the release with ... therapists has been trained knowing no other diagnostic scheme besides ... DSM-5 diagnostic manual will be released worldwide. In honor of ...
Breaking Medicine News(10 mins):Health News:Tim Smucker and Danny Wegman Honored With GS1 Lifetime Achievement Awards 2Health News:Tim Smucker and Danny Wegman Honored With GS1 Lifetime Achievement Awards 3Health News:A pan-European study: Signs of motor disorders can appear years before disease manifestation 2Health News:A pan-European study: Signs of motor disorders can appear years before disease manifestation 3Health News:Johns Hopkins rewrites obsolete blood-ordering rules 2Health News:Johns Hopkins rewrites obsolete blood-ordering rules 3Health News:TheBeautyPlace.com Divulges Two Innovative Hair Loss Concealers on the Market Today: Bosley Hair Thickening Fibers and Toppik Hair Building Fibers 2Health News:What You Need to Know About DSM-5: The Asheville Jung Center is Hosting a Webinar Tonight on the New Material in DSM-5 2
... STOCKHOLM, March 25 Dr. Bindeshwar Pathak, founder of,Sulabh ... Stockholm Water,Prize Laureate. , To ... , As the Founder of ... around the world for his wide ranging work in ...
... PARSIPPANY, N.J., March 25 It,s a different era ... of an ever-changing industry while battling an uncertain economy. ... the key to retaining market share and maintaining hard-earned ... tools of pharmaceutical competitive intelligence. , ...
... Bulls Legend BJ Armstrong Rallies Students to Get Fit By ... Grant CHICAGO, March 25 Chicago Bulls legend BJ ... fitness game as part of a new national campaign called ... of a new partnership between the "got milk?" Body By Milk(R) ...
... thickness, study finds , , WEDNESDAY, March 25 (HealthDay News) -- ... be associated with a higher risk for depression, U.S. researchers ... 54, including those who did and did not have a ... depression in their family history had a 28 percent thinning ...
... Solution Offers Proactive Monitoring of Critical Systems to ... Patient Care EnhancementNEW YORK, March 25 CareTech ... and services provider for hospitals and health systems, ... desk solution across all hospitals that together comprise ...
... --Company Now Has Until October 26, 2009 to Regain Compliance ... 25 Peregrine Pharmaceuticals, Inc. (Nasdaq: PPHM) today ... provides Peregrine with an additional three months to ... now has until October 26, 2009 to regain compliance with ...
Cached Medicine News:Health News:Indian Sanitation Innovator and Social Reformer Awarded 2009 Stockholm Water Prize 2Health News:Support at Fever Pitch for Dynamic, Fresh Approach to Pharmaceutical Competitive Intelligence 2Health News:Got Milk?(R) and the NBA Showcase New National Teen Health and Fitness Initiative at Cesar E. Chavez Multicultural Center 2Health News:Got Milk?(R) and the NBA Showcase New National Teen Health and Fitness Initiative at Cesar E. Chavez Multicultural Center 3Health News:Got Milk?(R) and the NBA Showcase New National Teen Health and Fitness Initiative at Cesar E. Chavez Multicultural Center 4Health News:Got Milk?(R) and the NBA Showcase New National Teen Health and Fitness Initiative at Cesar E. Chavez Multicultural Center 5Health News:Brain 'Thinning' May Indicate Susceptibility to Depression 2Health News:CareTech Solutions Launches Robust Service Desk Solution to Support Clinical Applications and Technology within Continuum Health Partners Hospitals 2Health News:CareTech Solutions Launches Robust Service Desk Solution to Support Clinical Applications and Technology within Continuum Health Partners Hospitals 3Health News:Peregrine Pharmaceuticals Receives Additional Time to Regain Compliance With NASDAQ's Minimum Bid Price Rule 2
(Date:5/22/2013)... 22, 2013  MGT Capital Investments, Inc. (NYSE MKT: ... the Second Annual Marcum LLP MicroCap Conference on Thursday, ... at the Grand Hyatt Hotel.  ... will update investors and answer questions. (Logo: ... is scheduled to begin at 9:30 a.m. EDT.  MGT,s ...
(Date:5/22/2013)... MANALAPAN, N.J. , May 22, 2013 ... this opportunity to update shareholders about some recent company ... will expand its avenues of communication with shareholders. Integrating ... has launched a Facebook page and will post updates ... the Twitter hashtag is #medifirstusa. Says ...
(Date:5/22/2013)... May 22, 2013  Avanir Pharmaceuticals, Inc. (NASDAQ: ... overview of the company at the following conferences. ... Presentation date: Wednesday May 29, 2013 , Presentation time: ... Healthcare Conference , Presentation date: Wednesday June 5, 2013 ... A live webcast and 30-day archive of ...
Breaking Medicine Technology:MGT Capital Investments, Inc. To Present At The Second Annual Marcum LLP MicroCap Conference 2MGT Capital Investments, Inc. To Present At The Second Annual Marcum LLP MicroCap Conference 3MGT Capital Investments, Inc. To Present At The Second Annual Marcum LLP MicroCap Conference 4Medifirst Solutions, Inc. Announces Update To Shareholders 2Avanir Pharmaceuticals to Participate in Two Upcoming Investor Conferences 2
... May 18, 2011 Oclaro, Inc. (NASDAQ: ... communications and laser solutions, today outlined its complete line ... of future products.  As a leading provider of diodes ... leverage its world-class manufacturing operations, technology expertise and packaging ...
... 18, 2011 Cempra Pharmaceuticals Inc. today announced that Prabhavathi ... two upcoming investor conferences in Paris.  Dr. Fernandes will present ... a.m. CET, May 24, at the Hilton Arc de Triomphe. ... at 3:00 p.m. CET, May 24, at the Paris ...
Cached Medicine Technology:Oclaro Provides Complete Fiber Laser Diode Solutions Portfolio; Outlines Future Innovation and Technology Advancements 2Oclaro Provides Complete Fiber Laser Diode Solutions Portfolio; Outlines Future Innovation and Technology Advancements 3Cempra Pharmaceuticals to Present at Two Investor Conferences in Paris 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: