Navigation Links
New therapeutic target for lung cancer
Date:3/31/2011

A new therapeutic target for lung cancer has been discovered by researchers at Seoul National University. It was found that a variant of the protein AIMP2 is highly expressed in lung cancer cells and also that patients demonstrating high expression of this variant show lower survival. The study is published on March 31 in the open-access journal PLoS Genetics.

Lung cancer is one of the world's most common cancers and a leading cause of death resulting from cancer. Despite treatment with a combination of surgery, radiation and drugs, the survival rate for patients has not drastically improved over the past few decades. It had previously been shown that the protein AIMP2 acted as a tumor-suppressor by interacting with another oncosuppressor, p53. However, whether AIMP2 was indeed pathologically linked to human cancer had not been definitively proved. This investigation discovered that a variant of AIMP2 is highly expressed in human lung cancer cells. AIMP2-DX2 compromises the tumor-suppressing activity of AIMP2 by competitively binding to p53. It was also shown that suppression of AIMP2-DX2 slowed tumor growth, suggesting that this could be an exciting new therapeutic target.

New innovative therapies are important not only because of the high mortality rate associated with lung cancer, but because the majority of the drugs are cytotoxic, causing many adverse effects. These findings could create an opportunity to develop new innovative cancer drugs, as well as presenting a new target that could also be applied to other cancers.


'/>"/>

Contact: Sunghoon Kim
sungkim@snu.ac.kr
822-880-8180
Public Library of Science
Source:Eurekalert

Page: 1

Related medicine news :

1. McCain gives $5 million to St. Michael’s Hospital for therapeutic endoscopy
2. Researchers discover possible biomarker and therapeutic target for melanoma
3. Study identifies therapeutic target for liver cancer and predictive biomarker of response
4. Therapeutic lifestyle changes as useful as drugs in improving mental health
5. Mayo Clinic researchers confirm value of therapeutic hypothermia after cardiac arrest
6. Study compares balanced propofol sedation with conventional sedation for therapeutic GI endoscopic procedures
7. Save messengers -- modified mRNAs open up new therapeutic possibilities
8. Transplanted human placenta-derived stem cells show therapeutic potential in stroke models
9. Optimizing patient outcomes after therapeutic hypothermia for traumatic brain injury
10. Does Club Drug Ecstasy Have Therapeutic Value?
11. Autism Consortium 2010 Symposium: New therapeutics focus, family resource guide announced
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... The report, “Specialty Synthetic Fibers & Glass Fiber ... defines and segments the specialty synthetic fibers and ... of the volumes and values of types such ... UHMW Polyethylene, carbon fiber, partially oxidized polyacrylonitrile fiber, ... fiber, and liquid crystal polymer fiber and glass ...
(Date:7/11/2014)... July 11, 2014 Datalogic brings a ... improving sanitation hospital wide. With their new Gryphon ... of disease, like the devastating MRSA, which claimed 5,500 ... GD4400-HC 2D and the Gryphon GM4400-HC 2D ... and can even read barcodes off of troublesome LCD ...
(Date:7/11/2014)... July 11, 2014 Operators ... $50 billion in fuel costs now that ... current GHG standards are phasing ... it upon themselves to install new features ... 1.    Idle reduction technologies , 2.    Efficient driveline components ...
(Date:7/11/2014)... 2014 (HealthDay News) -- Children who have emergency ... complications and potentially even death than those who ... However, the Johns Hopkins researchers noted that ... researchers analyzed data on nearly 440,000 simple emergency ... over a 22-year period. The surgeries are ...
(Date:7/11/2014)... Ticket Down is a reliable source ... When it comes to the summer concert schedule, it just ... native is one of the biggest names in country music and ... currently out on his “That’s My Kind of Night” tour featuring ... will be making through the rest of the summer and into ...
Breaking Medicine News(10 mins):Health News:Specialty Synthetic Fibers & Glass Fiber Market Poised to Reach $20.1 Billion at a CAGR of 5.2% by 2018 – Report by MarketsandMarkets 2Health News:Specialty Synthetic Fibers & Glass Fiber Market Poised to Reach $20.1 Billion at a CAGR of 5.2% by 2018 – Report by MarketsandMarkets 3Health News:Specialty Synthetic Fibers & Glass Fiber Market Poised to Reach $20.1 Billion at a CAGR of 5.2% by 2018 – Report by MarketsandMarkets 4Health News:Stop Spreading Disease with the New Disinfectant-Ready Bar Code Scanner 2Health News:Stop Spreading Disease with the New Disinfectant-Ready Bar Code Scanner 3Health News:LeaseQ Agrees the Latest Round of Greenhouse Gas Rules Could Increase the Cost of Truck Acquisition and Maintenance 2Health News:LeaseQ Agrees the Latest Round of Greenhouse Gas Rules Could Increase the Cost of Truck Acquisition and Maintenance 3Health News:Emergency Surgeries on Weekends Riskier for Kids: Study 2Health News:Luke Bryan Ticket Prices Slashed at Concord Pavilion 2Health News:Luke Bryan Ticket Prices Slashed at Concord Pavilion 3
... 31 ev3 Inc. (Nasdaq:,EVVV) today announced that Pat ... are scheduled to present at the,Canaccord Adams 28th Annual ... p.m. Eastern Time. The Canaccord Adams 28th Annual Global,Growth ... Boston,Massachusetts., To access the webcast, go to the ...
... Call Today at 5:00 p.m. Eastern Time -, ... Poniard,Pharmaceuticals, Inc. (Nasdaq: PARD ), a biopharmaceutical ... progress and financial results,for the second quarter ended ... are to develop picoplatin as an oncology,platform compound ...
... July 31 Mylan Inc. (NYSE: MYL ),today ... stock,issuance, the company has declared its quarterly dividend of ... 6.5% and a liquidation,preference of $1,000.00 per share) payable ... record as of August 1, 2008., Mylan Inc., ...
... PARAMUS, N.J., July 31 Smart Balance Inc.,(Nasdaq: ... marketing organization,today. Richard McWilliams has been named to ... brands, reporting to Gregory Venner, executive,vice president and ... the marketing efforts for the Company,s core brands., ...
... ARBOR, Mich. Pat Phalin learned she had hearing loss ... her local school. The pupils heard sounds she could not ... a pattern in his wife,s family history. Her mother, grandfather ... the Phalins, children had hearing problems before he reached school ...
... ST. LOUIS, July 31 Stereotaxis, Inc. (Nasdaq:,STXS) ... results for the,second quarter ended June 30, 2008, ... The Company will host a conference call and ... Eastern Time to discuss the Company,s,second quarter results ...
Cached Medicine News:Health News:Poniard Pharmaceuticals Reports Second Quarter 2008 Financial Results and Corporate Update 2Health News:Poniard Pharmaceuticals Reports Second Quarter 2008 Financial Results and Corporate Update 3Health News:Poniard Pharmaceuticals Reports Second Quarter 2008 Financial Results and Corporate Update 4Health News:Poniard Pharmaceuticals Reports Second Quarter 2008 Financial Results and Corporate Update 5Health News:Poniard Pharmaceuticals Reports Second Quarter 2008 Financial Results and Corporate Update 6Health News:Poniard Pharmaceuticals Reports Second Quarter 2008 Financial Results and Corporate Update 7Health News:Poniard Pharmaceuticals Reports Second Quarter 2008 Financial Results and Corporate Update 8Health News:Poniard Pharmaceuticals Reports Second Quarter 2008 Financial Results and Corporate Update 9Health News:Smart Balance Announces Marketing Organization Appointment 2Health News:Inherited form of hearing loss stems from gene mutation 2Health News:Inherited form of hearing loss stems from gene mutation 3
(Date:7/10/2014)... July 10, 2014 Decision Resources Group finds ... the U.S. Food and Drug Administration,s (FDA) approval of ... Velphoro, which was approved by the FDA in November ... disease (CKD) patients on dialysis. Other key ... (US) Q2 2014 : ...
(Date:1/15/2014)... Jan. 15, 2014 Most osteoporosis patients want a ... recent online survey* sponsored by Mission Pharmacal Company. The ... Osteoporosis Foundation online support community, revealed that 74 percent ... comes in a form other than a pill or ...
(Date:1/15/2014)... 15, 2014 AARP Foundation today announced it has established ... from the severe cold weather that has gripped much of ... those in need; so to support these emergency relief efforts ... $250,000, which could mean up to $500,000 in aid. The ...
Breaking Medicine Technology:Half of Surveyed Nephrologists Report Moderate Familiarity with Velphoro, Which Received FDA Approval Late Last Year for the Treatment of Hyperphosphatemia in Dialysis 2Half of Surveyed Nephrologists Report Moderate Familiarity with Velphoro, Which Received FDA Approval Late Last Year for the Treatment of Hyperphosphatemia in Dialysis 3Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 2Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 3AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 2AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 3
... N.J., Oct. 30 Novo Nordisk Inc. announced the ... hemophilia(TM) campaign through a rebranded Web site and ... face many daily challenges, and Novo Nordisk is committed ... a lifetime of possibilities. , These new online resources ...
... GUANGZHOU, China, Oct. 30 ... CHME) ("China Medicine" or "the Company"), a ... pharmaceuticals,traditional Chinese medicines ("TCM"), nutritional and dietary ... announced that through its,wholly-owned subsidiary in China, ...
Cached Medicine Technology:Novo Nordisk is Changing Possibilities in Hemophilia 2Novo Nordisk is Changing Possibilities in Hemophilia 3China Medicine Corporation to Acquire Pharmaceutical Manufacturer in Guangzhou 2China Medicine Corporation to Acquire Pharmaceutical Manufacturer in Guangzhou 3China Medicine Corporation to Acquire Pharmaceutical Manufacturer in Guangzhou 4
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: