Navigation Links
New theory turns cancer on its head
Date:7/14/2014

A new theory of how cancer works could lead to the next generation of treatments of the disease.

The theory suggests that cancer forms when recently evolved genes are damaged, and cells have to revert to using older, inappropriate genetic pathways.

Astrobiologists Dr Charley Lineweaver from The Australian National University and Professor Paul Davies from Arizona State University teamed up with oncologist Dr Mark Vincent from the University of Western Ontario to develop the new model.

"The rapid proliferation of cancer cells is an ancient, default capability that became regulated during the evolution of multicellularity about a billion years ago," says Dr Lineweaver.

"Our model suggests that cancer progression is the accumulation of damage to the more recently acquired genes. Without the regulation of these recent genes, cell physiology reverts to earlier programs, such as unregulated cell proliferation."

In 2012 about 14.1 million new cases of cancer occurred globally, yet an underlying cause of the many forms of the disease has not yet been identified. To understand the disease better the team turned to the wealth of knowledge being revealed in the genome sequences from a large range of our distant relatives, including fish, corals and sponges.

This new knowledge has allowed scientists to establish the order in which genes evolved and is the basis of the new therapeutic implications of the model, said Dr Lineweaver.

"The adaptive immune system that humans have has evolved relatively recently, and it seems cancer cells do not have the ability to talk to and be protected by it. The new therapeutic strategies we are proposing target these weaknesses," he said.

"These strategies are very different from current therapies, which attack cancer's strength its ability to proliferate rapidly."

Professor Davies says the new model will not provide an overnight cure.

"It is a work in progress but we think it gives a more consistent interpretation of what is currently known about cancer than other models do," he said.

Dr Lineweaver says that his research in astrobiology led him to look at cancer.

"Paul and I have always been interested in trying to answer big questions. This led us to astrobiology and trying to answer the question 'Are we alone?' To answer that, you need to know about how life got started and evolved on this planet, and that involves understanding the evolution of multicellularity. That is an obviously missing piece from our current models of cancer."

A video summary of the research is available at http://www.youtube.com/user/WBLifeSciences


'/>"/>

Contact: Dr Charley Lineweaver
charley.lineweaver@anu.edu.au
61-261-256-717
Australian National University
Source:Eurekalert

Related medicine news :

1. Queuing theory helps physicist understand protein recycling
2. New theory on cause of endometriosis
3. Study casts doubt on theory that retired NFL players suffer CTE
4. Liz Deppe Joins Orangetheory Fitness
5. Orangetheory Fitness Set to Open First Southern Colorado Location in Early 2014
6. Conversations between lovers about STIs are important in theory but difficult in bed
7. Study offers new theory of cancer development
8. Study casts doubt on theory that retired NFL players suffer unique cognitive disorder
9. New theory uncovers cancers deep evolutionary roots
10. PhenObestin.com Announces Support For New Weight Loss Theory by author Dr. Khandee Ahnaimugan
11. Theory: Music underlies language acquisition
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... ... May 24, 2016 , ... ... today announced the official relaunch of its community and education hub for women ... Eggsurance's mission is to create a safe and welcoming place for women to ...
(Date:5/24/2016)... ... May 24, 2016 , ... The Radiosurgery Society (RSS), ... radiosurgery, is recognizing five medical residents and students for their outstanding contributions to ... The awards will be presented at the 2016 SRS/SBRT Scientific Meeting taking place ...
(Date:5/24/2016)... ... May 24, 2016 , ... The number of health ... or 10% over last year, according to data in the forthcoming AIS’s Directory ... comparatively stable, with a slight decrease in risk-based groups and a slight increase ...
(Date:5/24/2016)... ... May 24, 2016 , ... Bio-Logic Aqua® Research Water ... years and a trainer for Ageless Grace ( http://www.agelessgrace.com ) to discuss healthier ... May 16, 2016. , Formerly a Northwestern University Literature Professor, Kinst gravitated to ...
(Date:5/24/2016)... ... ... WaterAid launched the #perioddrama campaign to mark Menstrual Hygiene Day on May 28 ... world who do not have access to a toilet, even when they’re on their periods. ... #perioddrama. The (sometimes hilarious) results help shine a light on the awkwardness that women face ...
Breaking Medicine News(10 mins):
(Date:5/23/2016)... SAN FRANCISCO , May 23, 2016 ... expected to reach USD 5.0 billion by 2022, according ... The increasing generation of medical waste coupled with the ... healthcare industry is expected to drive the demand for ... with these devices as compared to that of the ...
(Date:5/20/2016)... 2016 The Biotech arena remains ... the industry is not far from recovering. There are ... the following four equities: Anacor Pharmaceuticals Inc. (NASDAQ: ... ), Aralez Pharmaceuticals Inc. (NASDAQ: ARLZ ), ... Sign up for your free trading alerts on these ...
(Date:5/19/2016)... Calif. , May 19, 2016  According ... thirds of the world lacks basic diagnostic imaging. ... in the United States , ... to such technology. In fact, the WHO reports ... risk of avoidable or treatable death, simply due ...
Breaking Medicine Technology: