Navigation Links
New theory turns cancer on its head
Date:7/14/2014

A new theory of how cancer works could lead to the next generation of treatments of the disease.

The theory suggests that cancer forms when recently evolved genes are damaged, and cells have to revert to using older, inappropriate genetic pathways.

Astrobiologists Dr Charley Lineweaver from The Australian National University and Professor Paul Davies from Arizona State University teamed up with oncologist Dr Mark Vincent from the University of Western Ontario to develop the new model.

"The rapid proliferation of cancer cells is an ancient, default capability that became regulated during the evolution of multicellularity about a billion years ago," says Dr Lineweaver.

"Our model suggests that cancer progression is the accumulation of damage to the more recently acquired genes. Without the regulation of these recent genes, cell physiology reverts to earlier programs, such as unregulated cell proliferation."

In 2012 about 14.1 million new cases of cancer occurred globally, yet an underlying cause of the many forms of the disease has not yet been identified. To understand the disease better the team turned to the wealth of knowledge being revealed in the genome sequences from a large range of our distant relatives, including fish, corals and sponges.

This new knowledge has allowed scientists to establish the order in which genes evolved and is the basis of the new therapeutic implications of the model, said Dr Lineweaver.

"The adaptive immune system that humans have has evolved relatively recently, and it seems cancer cells do not have the ability to talk to and be protected by it. The new therapeutic strategies we are proposing target these weaknesses," he said.

"These strategies are very different from current therapies, which attack cancer's strength its ability to proliferate rapidly."

Professor Davies says the new model will not provide an overnight cure.

"It is a work in progress but we think it gives a more consistent interpretation of what is currently known about cancer than other models do," he said.

Dr Lineweaver says that his research in astrobiology led him to look at cancer.

"Paul and I have always been interested in trying to answer big questions. This led us to astrobiology and trying to answer the question 'Are we alone?' To answer that, you need to know about how life got started and evolved on this planet, and that involves understanding the evolution of multicellularity. That is an obviously missing piece from our current models of cancer."

A video summary of the research is available at http://www.youtube.com/user/WBLifeSciences


'/>"/>

Contact: Dr Charley Lineweaver
charley.lineweaver@anu.edu.au
61-261-256-717
Australian National University
Source:Eurekalert

Related medicine news :

1. Queuing theory helps physicist understand protein recycling
2. New theory on cause of endometriosis
3. Study casts doubt on theory that retired NFL players suffer CTE
4. Liz Deppe Joins Orangetheory Fitness
5. Orangetheory Fitness Set to Open First Southern Colorado Location in Early 2014
6. Conversations between lovers about STIs are important in theory but difficult in bed
7. Study offers new theory of cancer development
8. Study casts doubt on theory that retired NFL players suffer unique cognitive disorder
9. New theory uncovers cancers deep evolutionary roots
10. PhenObestin.com Announces Support For New Weight Loss Theory by author Dr. Khandee Ahnaimugan
11. Theory: Music underlies language acquisition
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/27/2017)... ... 27, 2017 , ... Much attention has been paid to the problem of ... opioid painkillers has fallen short. From 1999 until 2010, fatal overdoses from prescription pain ... overdoses in male populations.(1) , The proportion of women using illicit drugs is also ...
(Date:2/27/2017)... ... 2017 , ... Elisa Guajardo Carothers is not your typical author. She went from working as ... Now, she writes about God, when she isn’t swimming as a performing mermaid. , Her ... BS! (Before Satan),” she offers a comedic look at the dysfunctions of God’s family, before ...
(Date:2/27/2017)... ... February 27, 2017 , ... ... on laser diffraction analysis as a tool to characterize particle size distributions in ... to obtain improved results and novel scientific findings. It describes methods of optimized ...
(Date:2/27/2017)... POUGHKEEPSIE, N. Y. (PRWEB) , ... February 27, 2017 , ... ... Society ( ILADS ) has disclosed that despite scientific studies, the Center for Disease ... of chronic Lyme disease . Kenneth B. Liegner, M.D. has compiled into ...
(Date:2/27/2017)... , ... February 27, 2017 , ... ... and alcohol treatment programs in British Columbia, Canada, at https://www.sunshinecoasthealthcentre.ca/ , is ... team. The new hire, Mackenzie Alsager, showcases the Centre's commitment to innovation in ...
Breaking Medicine News(10 mins):
(Date:2/28/2017)... 27, 2017  Market Research presents an all-encompassing and one ... market titled ,Medical Fiber Optics Market: Global Industry Analysis and ... globally across the five key regions of North ... Europe , APAC and MEA which influence the ... optics market over the forecast period. In this report, Persistence ...
(Date:2/28/2017)... TRIANGLE PARK, N.C. , Feb. 28, 2017 ... that Martine Rothblatt , Ph.D., Chairman and Chief Executive ... on the company,s business at the Cowen and Company 37 ... Massachusetts . The presentation will take place ... and can be accessed via a live webcast on the ...
(Date:2/28/2017)... 27, 2017  Clarivate Analytics marks the passing of one if its ... contributions to information science in the service of scientific and scholarly research. ... an indexing system that revolutionized the way researchers work with the literature, ... Continue Reading ... ...
Breaking Medicine Technology: