Navigation Links
New theory turns cancer on its head

A new theory of how cancer works could lead to the next generation of treatments of the disease.

The theory suggests that cancer forms when recently evolved genes are damaged, and cells have to revert to using older, inappropriate genetic pathways.

Astrobiologists Dr Charley Lineweaver from The Australian National University and Professor Paul Davies from Arizona State University teamed up with oncologist Dr Mark Vincent from the University of Western Ontario to develop the new model.

"The rapid proliferation of cancer cells is an ancient, default capability that became regulated during the evolution of multicellularity about a billion years ago," says Dr Lineweaver.

"Our model suggests that cancer progression is the accumulation of damage to the more recently acquired genes. Without the regulation of these recent genes, cell physiology reverts to earlier programs, such as unregulated cell proliferation."

In 2012 about 14.1 million new cases of cancer occurred globally, yet an underlying cause of the many forms of the disease has not yet been identified. To understand the disease better the team turned to the wealth of knowledge being revealed in the genome sequences from a large range of our distant relatives, including fish, corals and sponges.

This new knowledge has allowed scientists to establish the order in which genes evolved and is the basis of the new therapeutic implications of the model, said Dr Lineweaver.

"The adaptive immune system that humans have has evolved relatively recently, and it seems cancer cells do not have the ability to talk to and be protected by it. The new therapeutic strategies we are proposing target these weaknesses," he said.

"These strategies are very different from current therapies, which attack cancer's strength its ability to proliferate rapidly."

Professor Davies says the new model will not provide an overnight cure.

"It is a work in progress but we think it gives a more consistent interpretation of what is currently known about cancer than other models do," he said.

Dr Lineweaver says that his research in astrobiology led him to look at cancer.

"Paul and I have always been interested in trying to answer big questions. This led us to astrobiology and trying to answer the question 'Are we alone?' To answer that, you need to know about how life got started and evolved on this planet, and that involves understanding the evolution of multicellularity. That is an obviously missing piece from our current models of cancer."

A video summary of the research is available at


Contact: Dr Charley Lineweaver
Australian National University

Related medicine news :

1. Queuing theory helps physicist understand protein recycling
2. New theory on cause of endometriosis
3. Study casts doubt on theory that retired NFL players suffer CTE
4. Liz Deppe Joins Orangetheory Fitness
5. Orangetheory Fitness Set to Open First Southern Colorado Location in Early 2014
6. Conversations between lovers about STIs are important in theory but difficult in bed
7. Study offers new theory of cancer development
8. Study casts doubt on theory that retired NFL players suffer unique cognitive disorder
9. New theory uncovers cancers deep evolutionary roots
10. Announces Support For New Weight Loss Theory by author Dr. Khandee Ahnaimugan
11. Theory: Music underlies language acquisition
Post Your Comments:
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... As health ... medicine known as “patient engagement.” The patient is doing more than filling out a ... , “There is an increasing emphasis in health care and research on the ...
(Date:10/13/2017)... Ky. (PRWEB) , ... October 13, 2017 , ... The ... MPH to become its next President and Chief Executive Officer, succeeding Dr. James C. ... CEO Elect beginning July 1, 2018 until Dr. Puffer’s retirement at the end of ...
(Date:10/13/2017)... ... October 13, 2017 , ... PurhealthRX , a leading ... Purzorb™ technology. Applying the Purzorb™process to full spectrum CBD oil will revolutionize the rapidly ... CBD form that can be easily incorporated into liquid products, while reducing costs to ...
(Date:10/13/2017)... QUEENS, N.Y (PRWEB) , ... October 13, 2017 , ... ... recently became a member of ElderCounsel, a national organization of elder law and special ... constantly changing laws and rules. It also provides a forum to network with elder ...
(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term insurance that covers care ... have a waiver for care if the client has a cognitive impairment diagnosis. ... for care, is often waived, so the benefits from their insurance start immediately,” said ...
Breaking Medicine News(10 mins):
(Date:9/19/2017)... , Sept. 19, 2017   ZirMed Inc ., a ... today announced that it has been ranked #1 by its ... Book™ Rankings 2017 User Survey. ZirMed was recognized as ... large hospitals and medical centers over 200 beds and holds ... healthcare technology user survey history. ...
(Date:9/13/2017)... OrthoAtlanta has been named the official orthopedic and sports ... the 2018 College Football Playoff (CFP) National Championship to be ... Atlanta, Georgia . OrthoAtlanta is proud to ... in many activities leading up to, and including the national ... OrthoAtlanta ...
(Date:9/12/2017)... Sept. 12, 2017  ValGenesis Inc., the global ... is pleased to announce the appointment of Dr. ... its Board of Directors and Chairman of Advisory ... life science companies to manage their entire validation ... paper in this process. Furthermore, ValGenesis VLMS enables ...
Breaking Medicine Technology: