Navigation Links
New theory turns cancer on its head
Date:7/14/2014

A new theory of how cancer works could lead to the next generation of treatments of the disease.

The theory suggests that cancer forms when recently evolved genes are damaged, and cells have to revert to using older, inappropriate genetic pathways.

Astrobiologists Dr Charley Lineweaver from The Australian National University and Professor Paul Davies from Arizona State University teamed up with oncologist Dr Mark Vincent from the University of Western Ontario to develop the new model.

"The rapid proliferation of cancer cells is an ancient, default capability that became regulated during the evolution of multicellularity about a billion years ago," says Dr Lineweaver.

"Our model suggests that cancer progression is the accumulation of damage to the more recently acquired genes. Without the regulation of these recent genes, cell physiology reverts to earlier programs, such as unregulated cell proliferation."

In 2012 about 14.1 million new cases of cancer occurred globally, yet an underlying cause of the many forms of the disease has not yet been identified. To understand the disease better the team turned to the wealth of knowledge being revealed in the genome sequences from a large range of our distant relatives, including fish, corals and sponges.

This new knowledge has allowed scientists to establish the order in which genes evolved and is the basis of the new therapeutic implications of the model, said Dr Lineweaver.

"The adaptive immune system that humans have has evolved relatively recently, and it seems cancer cells do not have the ability to talk to and be protected by it. The new therapeutic strategies we are proposing target these weaknesses," he said.

"These strategies are very different from current therapies, which attack cancer's strength its ability to proliferate rapidly."

Professor Davies says the new model will not provide an overnight cure.

"It is a work in progress but we think it gives a more consistent interpretation of what is currently known about cancer than other models do," he said.

Dr Lineweaver says that his research in astrobiology led him to look at cancer.

"Paul and I have always been interested in trying to answer big questions. This led us to astrobiology and trying to answer the question 'Are we alone?' To answer that, you need to know about how life got started and evolved on this planet, and that involves understanding the evolution of multicellularity. That is an obviously missing piece from our current models of cancer."

A video summary of the research is available at http://www.youtube.com/user/WBLifeSciences


'/>"/>

Contact: Dr Charley Lineweaver
charley.lineweaver@anu.edu.au
61-261-256-717
Australian National University
Source:Eurekalert

Related medicine news :

1. Queuing theory helps physicist understand protein recycling
2. New theory on cause of endometriosis
3. Study casts doubt on theory that retired NFL players suffer CTE
4. Liz Deppe Joins Orangetheory Fitness
5. Orangetheory Fitness Set to Open First Southern Colorado Location in Early 2014
6. Conversations between lovers about STIs are important in theory but difficult in bed
7. Study offers new theory of cancer development
8. Study casts doubt on theory that retired NFL players suffer unique cognitive disorder
9. New theory uncovers cancers deep evolutionary roots
10. PhenObestin.com Announces Support For New Weight Loss Theory by author Dr. Khandee Ahnaimugan
11. Theory: Music underlies language acquisition
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... AR (PRWEB) , ... October 13, 2017 , ... ... with locations throughout Arkansas that offers insurance and financial preparation services, is providing ... the Rock City Rescue organization. , Rock City Rescue is a locally recognized ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... process to promote standards of excellence for the field of eating disorders, announces ... 22 – 25, 2018 in Orlando, Florida at the Omni Resort at ChampionsGate. ...
(Date:10/13/2017)... ... 2017 , ... Apple Rehab Shelton Lakes , which specializes in the ... facility as part of a disaster drill on October 3rd. , Apple Rehab participated ... Emergency Manager, as well as the Connecticut Long Term Care Mutual Aid Plan ...
(Date:10/13/2017)... NJ (PRWEB) , ... October 13, 2017 , ... Global ... at scenic Alexandria Park in Milford, NJ. This free event, sponsored by Global ... physical activity. The fun run is geared towards children of all ages; it ...
(Date:10/13/2017)... , ... October 13, 2017 , ... “The Journey: From ... every danger possible to save lost souls in the Philippines. “The Journey: From the ... is a dedicated teacher of the Bible. She has taught all ages and currently ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... IRVING, Texas , Oct. 11, 2017  Caris ... science focused on fulfilling the promise of precision medicine, ... Institute has joined Caris, Precision Oncology Alliance™ (POA) as ... leading cancer centers, the St. Jude Crosson Cancer Institute ... to advance the use of tumor profiling, making cancer ...
(Date:10/10/2017)... 2017   West Pharmaceutical Services, Inc. (NYSE: ... drug administration, today shared the results of a study ... the intradermal administration of polio vaccines. The study results ... May 2017 by Dr. Ondrej Mach , Clinical ... Organization (WHO), and recently published in the journal ...
(Date:10/4/2017)... the Centers for Disease Control and Prevention (CDC), influenza vaccination should ... helping communities across Massachusetts , Connecticut ... shots through the end of the month. *Some exclusions apply ... ... is by the end of October, according to the Centers for Disease ...
Breaking Medicine Technology: