Navigation Links
New theory on cause of endometriosis
Date:3/7/2014

Changes to two previously unstudied genes are the centerpiece of a new theory regarding the cause and development of endometriosis, a chronic and painful disease affecting 1 in 10 women.

The discovery by Northwestern Medicine scientists suggests epigenetic modification, a process that enhances or disrupts how DNA is read, is an integral component of the disease and its progression. Matthew Dyson, research assistant professor of obstetrics and gynecology at Northwestern University Feinberg School of Medicine and and Serdar Bulun, MD, chair of obstetrics and gynecology at Feinberg and Northwestern Memorial Hospital, also identified a novel role for a family of key gene regulators in the uterus.

"Until now, the scientific community was looking for a genetic mutation to explain endometriosis," said Bulun, a member of the Center for Genetic Medicine and the Robert H. Lurie Comprehensive Cancer Center of Northwestern University. "This is the first conclusive demonstration that the disease develops as a result of alterations in the epigenetic landscape and not from classical genetic mutations."

The findings were recently published in PLoS Genetics.

Women develop endometriosis when cells from the lining of the uterus, usually shed during menstruation, grow in other areas of the body. The persistent survival of these cells results in chronic pelvic pain and infertility. Although the cause of the disease has remained unknown on a cellular level, there have been several different models established to explain its development.

Endometriosis only occurs in menstruating primates, suggesting that the unique evolution behind uterine development and menstruation are linked to the disease. Scientists consider retrograde menstruation cells moving up the fallopian tubes and into the pelvis as one probable cause. Previous models, however, have been unable to explain why only 10 percent of women develop the disease when most experience retrograde menstruation at some point. Nor do they explain instances of endometriosis that arise independent of menstruation.

Bulun and Dyson propose that an epigenetic switch permits the expression of the genetic receptor GATA6 rather than GATA2, resulting in progesterone resistance and disease development.

"We believe an overwhelming number of these altered cells reach the lining of the abdominal cavity, survive and grow," Bulun said. "These findings could someday lead to the first noninvasive test for endometriosis."

Clinicians could then prevent the disease by placing teenagers predisposed to this epigenetic change on a birth control pill regimen, preventing the possibility of retrograde menstruation in the first place, Bulun said.

Dyson will also look to use the epigenetic fingerprint resulting from the presence of GATA6 rather than GATA2 as a potential diagnostic tool, since these epigenetic differences are readily detectable.

"These findings have the potential to shift how we view and treat the disease moving forward," Bulun said.


'/>"/>

Contact: Marla Paul
marla-paul@northwestern.edu
312-503-8928
Northwestern University
Source:Eurekalert

Related medicine news :

1. Study casts doubt on theory that retired NFL players suffer CTE
2. Liz Deppe Joins Orangetheory Fitness
3. Orangetheory Fitness Set to Open First Southern Colorado Location in Early 2014
4. Conversations between lovers about STIs are important in theory but difficult in bed
5. Study offers new theory of cancer development
6. Study casts doubt on theory that retired NFL players suffer unique cognitive disorder
7. New theory uncovers cancers deep evolutionary roots
8. PhenObestin.com Announces Support For New Weight Loss Theory by author Dr. Khandee Ahnaimugan
9. Theory: Music underlies language acquisition
10. New Study Debunks Virus Theory for Chronic Fatigue Syndrome
11. Researchers hit back at early bodycheck theory
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/20/2017)... ... ... Population Health Software Company, is pleased to announce a move to a larger office building ... size of the previous location while bringing life back to a medical practice building that ... excited to expand our footprint to better serve our growing client base. We are ...
(Date:2/20/2017)... Tampa, FL (PRWEB) , ... February 20, 2017 ... ... $20,000 gift from Constellation Brands to purchase a new ultrasound-enhanced thrombolysis machine, a ... ultrasonic waves. The gift was facilitated by the Pepin Family Foundation. , “We ...
(Date:2/19/2017)... , ... February 19, 2017 , ... ... for connected home healthcare, will join forces with Healthwise ® at ... Healthwise, the industry leader in evidence-based health education, technology and services, will ...
(Date:2/18/2017)... Texas (PRWEB) , ... February 17, 2017 , ... Park ... Moore’s “Oh Behave” Show on the Pet Life Radio network. The episode, which ... a number of topics including: what factors led to Park Cities Pet Sitter’s being ...
(Date:2/17/2017)... ... February 17, 2017 , ... The ... systems change designed to further positively impact the health and wellness of our ... long considered it our duty to seriously consider releasing our assets beyond our ...
Breaking Medicine News(10 mins):
(Date:2/20/2017)... ORLANDO, Fla. , Feb. 20, 2017 /PRNewswire/ ... are helping physicians diagnose and treat patients with ... will provide wireless connectivity for ZywiePro, Zywie,s cardiac ... AT&T Control Center . AT&T ... accessible monitoring for those with the disease. The ...
(Date:2/20/2017)... , Feb. 20, 2017 Seal Shield LLC ... IT solution for mobile device management and disinfection, the ... Conference and Exhibition in Orlando, Fla. ... Mobile devices have become commonplace in today,s healthcare ... new set of concerns, including the disinfection and tracking ...
(Date:2/20/2017)... Feb. 20, 2017 Research and Markets has ... Freezer Market Analysis and Trends - Product (RFID refrigerators and RFID ... 2025" report to their offering. ... The Global RFID Blood Refrigerator and Freezer ... from 2015 to 2025. This industry report analyzes ...
Breaking Medicine Technology: