Navigation Links
New test predicted presence of harmful BRCA mutations
Date:1/22/2013

PHILADELPHIA A new multiple gene expression profile test was able to predict the presence of harmful BRCA1 or BRCA2 mutations in otherwise healthy women carrying the mutations, according to data published in Cancer Prevention Research, a journal of the American Association for Cancer Research.

"This novel technology aims to provide a layer of information regarding the cell functionality aspect of BRCA mutations that could greatly enhance the doctor's ability to identify high-risk carriers," said Asher Y. Salmon, M.D., a breast cancer specialist at the Hadassah Hebrew University Medical Center in Jerusalem, Israel.

Women with a mutation in their BRCA1 or BRCA2 gene have a significantly increased risk for developing breast cancer or ovarian cancer, and for many of those at risk disease may develop at an early age. Researchers are investigating ways to detect these genetic mutations so women carrying the genes can consider taking measures to reduce their cancer risk or increase the chance for detecting cancer in its early stages.

"The current tool for mutation detection is gene sequencing, which is expensive, time-consuming and, in many cases, lacking clear and decisive clinical decision making information," said Salmon. "In many cases, the current sequencing tool identifies a mutation, but we do not know if the mutation is neutral or harmful."

According to Salmon, emerging evidence has revealed that cells with a mutation in one of the two copies of the BRCA1 or BRCA2 genes have a distinct gene expression profile when exposed to causes of DNA damage, such as radiation.

After collecting white blood cells from blood samples donated by nine healthy women with a mutated BRCA1 gene and eight healthy women with a mutated BRCA2 gene, Salmon and his colleagues cultured the cells and exposed them to radiation. They then extracted the total RNA from these cells and compared it to the total RNA from identically treated
'/>"/>

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Sharp spike in computer-related injuries predicted for medical workers, find studies
2. Flu outbreaks predicted with weather forecast techniques
3. Can breast cancer cells reaction to cancer drugs be predicted?
4. Population displacement during disasters predicted using mobile data
5. Worldwide Cancer Incidence Predicted to Rise 75% by 2030
6. Damaka introduces Xabr™, a Native Mobile Video & Collaboration Client for Cisco® Jabber®, CallManager, and TelePresence
7. Robot allows remote presence in programming brain and spine stimulators
8. Catalyst Exhibits Brings Big Presence to 2012 RSNA Show
9. Indesign, LLC Broadens Presence in Bluetooth with Bluetooth Low Energy - BLE
10. Presence of fetal cells in women lowers risk of breast cancer but raises risk of colon cancer
11. Harmful effects of bisphenol A proved experimentally
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/12/2014)... The rise in the number of mobility ... network architectures to suit the upsurge. Virtualization has become ... cloud storage technologies. The data traffic has increased by ... This has resulted in larger and more complex networks. ... the SDN market. , The North American (NA) region ...
(Date:7/12/2014)... July 12, 2014 In ... report, ‘cognitive assessment and training’ is defined ... assess, train, or enhance cognitive functions. These ... as in dementia screening, clinical trials, driver’s ... learning, self assessment, brain training, and employers’ ...
(Date:7/12/2014)... New York, New York (PRWEB) July 12, 2014 ... involving liver damage allegations continue to move forward ... District Court, Eastern District of Pennsylvania, Bernstein Liebhard ... 1, 2014, U.S. District Judge Lawrence F. Stengel ... president. Among other things, Judge Stengel found that ...
(Date:7/12/2014)... 12, 2014 "The second toes cross over ... painful to wear shoes," said an inventor from East Hartford, ... prevents this from happening. , He then created a prototype ... prevent the second and big toes from overlapping. This avoids ... shoes. Ergonomic and easy to use, it's ideal for people ...
(Date:7/12/2014)... 2014 As DePuy Pinnacle hip lawsuits ... courts, Bernstein Liebhard LLP notes the publication of a ... the failure of metal-on-metal hip replacements. The research, which ... of Bone & Joint Surgery, looked at 597 ... prostheses at least twelve months earlier. The blood metal ...
Breaking Medicine News(10 mins):Health News:North America Software Defined Network (SDN) Market Worth $1,443.8 Million by 2019 - New Report by MicroMarket Monitor 2Health News:North America Software Defined Network (SDN) Market Worth $1,443.8 Million by 2019 - New Report by MicroMarket Monitor 3Health News:North America Software Defined Network (SDN) Market Worth $1,443.8 Million by 2019 - New Report by MicroMarket Monitor 4Health News:North America Software Defined Network (SDN) Market Worth $1,443.8 Million by 2019 - New Report by MicroMarket Monitor 5Health News:Global Cognitive Assessment & Training Market: 27.3% CAGR to 2018 Says a New Research Report Available at LifeScienceIndustryResearch.com 2Health News:Global Cognitive Assessment & Training Market: 27.3% CAGR to 2018 Says a New Research Report Available at LifeScienceIndustryResearch.com 3Health News:Global Cognitive Assessment & Training Market: 27.3% CAGR to 2018 Says a New Research Report Available at LifeScienceIndustryResearch.com 4Health News:Global Cognitive Assessment & Training Market: 27.3% CAGR to 2018 Says a New Research Report Available at LifeScienceIndustryResearch.com 5Health News:Tylenol Lawsuit News: U.S. District Judge Overseeing Federal Tylenol Liver Damage Litigation Orders Deposition of Former McNeil President, Bernstein Liebhard LLP Reports 2Health News:Tylenol Lawsuit News: U.S. District Judge Overseeing Federal Tylenol Liver Damage Litigation Orders Deposition of Former McNeil President, Bernstein Liebhard LLP Reports 3Health News:Tylenol Lawsuit News: U.S. District Judge Overseeing Federal Tylenol Liver Damage Litigation Orders Deposition of Former McNeil President, Bernstein Liebhard LLP Reports 4Health News:DePuy Pinnacle Hip Lawsuit News: Bernstein Liebhard LLP Notes Release of New Study Tying Elevated Metal Ions to Metal-on-Metal Hip Failure 2Health News:DePuy Pinnacle Hip Lawsuit News: Bernstein Liebhard LLP Notes Release of New Study Tying Elevated Metal Ions to Metal-on-Metal Hip Failure 3Health News:DePuy Pinnacle Hip Lawsuit News: Bernstein Liebhard LLP Notes Release of New Study Tying Elevated Metal Ions to Metal-on-Metal Hip Failure 4
... was a key aspect for countries that recently have made ... on Monday by Save the Children, the New York ... Saving the Lives of Children Under 5," ranked the best ... 60 developing countries where 94% of child deaths occur. The ...
... is to be amputated with no recourse, injected stem cells ... stem cells offer immense hope to scientists, when the ... scientists have explored the potential of stem cells to cure ... it came to light, that special class of stem cells ...
... of its kind, researchers from Wake Forest University School ... other races to become living kidney donors, and ... donor evaluation. ,"Obesity is a growing problem ... reflects what we found in the study," said Amber ...
... for the first time in the United States a ... deadly blood clot in a patient suffering from deep ... Abbas Chamsuddin, MD, associate professor of interventional radiology in ... major system of clotting that filled the veins of ...
... kidney stones, Indrajit Roy wanted to get the best cure ... to remove the stone in a bloodless laser-aided operation ... his prayers were answered. ,Roy, 32, of Bally ... in Salt Lake, where doctors found a 500-gram stone embedded ...
... supplements have skyrocketed by 100 percent in the United ... people dont consider evidence-based indications before using them, according ... months Mayo Clinic Proceedings. ,Two-thirds of people ... scientific guidelines, according to the article. Meanwhile, sales of ...
Cached Medicine News:Health News:Family Planning Initiatives Central To Reducing Child Mortality in Developing Countries 2Health News:Study Evaluates the Incompetence of Blacks as Living Kidney Donors 2Health News:First Ultrasound Thrombolysis in U.S. Performed at Emory University Hospital 2
(Date:7/10/2014)... Ariz. , July 10, 2014   Ventana ...  Group, today announced it has entered into an agreement ... which operates as EMD Serono in the ... , to collaborate with Merck KGaA,s biopharmaceutical division on ... for an undisclosed target using Ventana,s proprietary diagnostic assays. ...
(Date:1/15/2014)... MILTON, N.Y. , Jan. 15, 2014 Sono-Tek Corporation ... three months ended November 30, 2013, compared to sales of ... or 20%. Once again, this quarter has also shown growth ... in the first quarter of this fiscal year. Markets that ...
(Date:1/15/2014)... , Jan. 15, 2014 AARP Foundation today announced ... older adults suffering from the severe cold weather that has ... committed to helping those in need; so to support these ... contributions up to $250,000, which could mean up to $500,000 ...
Breaking Medicine Technology:Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 2Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 3Sono-Tek Announces Third Quarter Results 2Sono-Tek Announces Third Quarter Results 3Sono-Tek Announces Third Quarter Results 4AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 2AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 3
... Eurotech , a leading supplier of embedded technologies, ... to supply embedded computers to a medical ...  The value of the six-month contract is about 1.5M ... Sphere II will allow the customer to meet market ...
... GENEVA and LOS ANGELES, Aug. 30, 2011 ... and consulting firm serving the life sciences industry, ... Switzerland consistent with its global growth strategy. The ... linguistic regions. They will be closely aligned with ...
Cached Medicine Technology:Eurotech Awarded 1.5M USD Contract to Supply Embedded Computers for Medical Application 2Bench International Expands Presence in Europe with Opening of Offices in Switzerland 2
... the advance of digital imaging technology, ... towards digital formats, allowing for easier ... advance in digital pathology imaging is ... in radiology, and which is continuing ...
Inquire...
PRINCIPLE: The QC-SLIDES™ are specifically designed microscope slides intended to be part of the quality control program to monitor microbiological stains and staining techniques....
Each slide contains a gram positive control of Staphylococcus aureus ATCC ® 25923 and a gram negative control of Escherichia coli ATCC ® 25922....
Medicine Products: