Navigation Links
New test offers greater accuracy in early detection of colorectal cancer
Date:1/19/2012

he polyps and prevent a subsequent cancer from forming, Dr. Ahlquist says.

First Study Highlights Stool DNA Test's Accuracy

Titled "Next-Generation Stool DNA Testing for Detection of Colorectal Neoplasia: Early Clinical Evaluation," the first article features results from the first large-scale study to measure the test's accuracy:

  • Across nearly 400 cases, the stool DNA test detected 87 percent of curable-stage colorectal cancer. Importantly, detection sensitivity was not affected by tumor location or stage.
  • The test detected the majority of large precancerous polyps at high risk for cancer progression.
  • Sensitivity was 64 percent for polyps larger than 1 centimeter (cm), 77 percent for those larger than 2 cm and 92 percent for those larger than 4 cm.

"These data illustrate the strength of the multi-marker stool DNA test to the critical screening targets -- pre-cancers and early-stage cancer," says co-investigator Stephen Thibodeau, Ph.D., a genetics researcher at Mayo Clinic." And, importantly, this test appears to uniquely represent an accurate noninvasive approach to large polyp detection, which offers the promise of actually preventing cancers from developing."

Second Publication Compares Screening Methods

The second article, titled "Stool DNA vs. Plasma Septin 9 Testing," uses the results of the first study to compare the sensitivities of the stool DNA test and a plasma test for methylated Septin 9 (SEPT9) in identifying patients with large adenomas or colorectal cancer. Highlights include:

  • The stool DNA test detected 82 percent of precancerous polyps compared to only 14 percent detected by SEPT9.
  • The stool DNA identified 87 percent of cancers at any stage, compared to 60 percent with SEPT9.
  • Stool DNA was even more effective at detecting curable-stage cancer (Stage I, II or III), detecting such cases 91 percent of the time, compared to just 50 percent w
    '/>"/>

Contact: Brian Kilen
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Theravive.com Offers A Free Therapist Listing For Credentialed Counselors and Psychologists
2. Autism Science Foundation Offers IMFAR Grants to Autism Stakeholders
3. PERSONALABS Offers Discounted Healthy Heart Online Blood Tests in February
4. CED Solutions Offers Free 3-Day Technical Windows 7 Certification Course for Unemployed Individuals
5. Is a Tummy Tuck Right for Me? Alabama Plastic Surgeon Dr. David Durst Offers Tips as the Popularity of Surgical Cosmetic Enhancement Continues to Rise
6. AGA offers new recommendations for CRC surveillance for certain patients with IBD
7. Research validates surgery alone offers reasonable overall survival for stage I SCLC
8. Electronic Interconnect Offers Medical Electronics, PCBs, Design Engineering
9. Lo Cest Offers a Free Download of a New Bible for the Gay Community
10. MU offers training program to improve health literacy
11. Hawaiian-shirt.net Offers 10 Tips To Beat The Winter Blues: Things You Can Do Right Now to Have a Better Day
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Blue Cross and Blue Shield of Minnesota (Blue ... means to “Live Fearless.” , The “Faces of ... stories about how they or someone they know has faced ... in the moment. By telling these types of stories through ...
(Date:1/22/2015)... A new white paper by The ... in the long-term care environment as well as provides ... The paper, “The Power of Person-Centeredness in Long-Term Care: ... of the patient, resident and family experience in long-term ...
(Date:1/22/2015)... 22, 2015 Carinsurancesavings.biz has released a new ... and dismemberment insurance . , Purchasing an accidental death ... very advantageous. This type of rider provides benefits if the ... be considered a lesser form of life insurance. , ...
(Date:1/22/2015)... (PRWEB) January 23, 2015 Recently, Weddingshe.com has ... catalog, and has announced its highest annual revenues in the ... on its popular glamorous wedding dresses. , According to the ... important wedding dress promotions for them in 2015. This point ...
(Date:1/22/2015)... IPSWICH, Mass. (PRWEB) January 22, 2015 ... Association (AMA) are expanding their relationship in an effort ... journals around the world. While EBSCO has long made AMA ... as a sales agent for The JAMA Network. ...
Breaking Medicine News(10 mins):Health News:Blue Cross and Blue Shield of Minnesota to Showcase “Faces of Fearless” 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3Health News:Accidental Death and Dismemberment Insurance Can Be Purchased at Low Prices Online 2Health News:Weddingshe Announces A Special Offer On Its Popular Glamorous Wedding Dresses 2Health News:EBSCO Expands Partnership with the American Medical Association 2Health News:EBSCO Expands Partnership with the American Medical Association 3Health News:EBSCO Expands Partnership with the American Medical Association 4
... New England,s largest fertility clinics expands to 12 ... Science Center,(RSC) of New England, the seventh largest ... partnership with Lowell General Hospital with,the opening of ... North Chelmsford at 10 Research Place, Suite 250., ...
... of low-risk patients are almost always benign and do not ... patients. This finding is significant because incidental adrenal lesions ... say. , The study included 973 patients with 1,049 adrenal ... of a hormonally active adrenal mass, said Julie H. Song, ...
... for evaluation of small bowel pathologies (e.g., bleeding sources). ... time and reduced visibility by air and residual material. ... defoaming agents) have been tried to improve the quality ... has been recommended for bowel preparation for CE. , ...
... Na+/H+ exchanger (NHE1) is a transmembrane protein found in ... evacuate excessive H+ in the cytoplasm by means of ... of the upregulation of NHE-1 gene expression in human ... apoptosis of tumor cells, which is helpful for the ...
... Palmetto GBA, a,leading provider of technical and administrative services ... a retired Air Force,colonel and former executive with health ... board of directors., Shields, a resident of Isle ... for Louisville, Ky.-based Humana, where he had served as ...
... interferes with abnormal cell growth seen in pulmonary hypertension ... drug sorafenib (Nexavar) shows promise as a treatment for ... Center study. , During the study, nine patients took ... those given to cancer patients. The patients also continued ...
Cached Medicine News:Health News:Reproductive Science Center and Lowell General Hospital Announce Partnership in Infertility Treatment 2Health News:How does sodium phosphate combined with bisacodyl affect small intestine? 2Health News:Sorafenib Shows Promise for Heart-Lung Disease 2
(Date:1/23/2015)... Jan. 23, 2015  Pete Rose, baseball,s all-time hits leader, is ... pain reliever Myoflex, Ducere Pharma has announced. "Pete,s ... excited to have him on board with Myoflex," said Ducere ... a legendary player who is known across all generations. The ...
(Date:1/23/2015)... Jan. 23, 2015  iMD Companies, Inc. (ICBU) has repositioned itself ... share and grab a foothold in the hydroponic, hemp and ... and a presence in the sector, and recently partnering with ... of hemp and medical marijuana, iMD is committing to bring ...
(Date:1/23/2015)... 23, 2015   Leatt Corporation  (OTCQB: LEAT), a global ... all forms of sports, including extreme motor sports, and ... today that the UISP Lega Motociclismo Lombardia, an Italian ... to wear a neck brace during its racing competitions.  ...
Breaking Medicine Technology:Pete Rose bets on Myoflex to relieve aches and pains 2iMD Companies Poised to Make Impact in Multi-Billion Dollar Medical Marijuana Sector With Recent Investments and Strategic Partnerships 2Leatt Announces Neck Braces Now Required For Motocross/Minicross Racing In Italy 2Leatt Announces Neck Braces Now Required For Motocross/Minicross Racing In Italy 3
... Expected to be Reported in Q2 2008, ... (Nasdaq: ALXA ) announced today that it ... clinical trial with AZ-002,(Staccato(R) alprazolam) in patients with ... developed for the acute treatment of,panic attacks associated ...
... Quantum Immunologics, Inc. ("QI"),announces the commencement of ... and efficacy of a novel anti-cancer vaccine/immunotherapy that ... breast cancer. Patients accepted,into the study have previously ... radiation and/or chemotherapy. QI has commissioned,the study to ...
Cached Medicine Technology:Alexza Completes Enrollment in Phase 2a Clinical Trial With AZ-002 (Staccato(R) Alprazolam) in Panic Disorder Patients 2Alexza Completes Enrollment in Phase 2a Clinical Trial With AZ-002 (Staccato(R) Alprazolam) in Panic Disorder Patients 3Alexza Completes Enrollment in Phase 2a Clinical Trial With AZ-002 (Staccato(R) Alprazolam) in Panic Disorder Patients 4Quantum Immunologics, Inc. and the South Alabama Medical Science Foundation Announce an Early Clinical Evaluation of a Novel Immuno-therapeutic Vaccine for Treating Advanced Human Breast Carcinomas 2Quantum Immunologics, Inc. and the South Alabama Medical Science Foundation Announce an Early Clinical Evaluation of a Novel Immuno-therapeutic Vaccine for Treating Advanced Human Breast Carcinomas 3
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: