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New test offers greater accuracy in early detection of colorectal cancer
Date:1/19/2012

he polyps and prevent a subsequent cancer from forming, Dr. Ahlquist says.

First Study Highlights Stool DNA Test's Accuracy

Titled "Next-Generation Stool DNA Testing for Detection of Colorectal Neoplasia: Early Clinical Evaluation," the first article features results from the first large-scale study to measure the test's accuracy:

  • Across nearly 400 cases, the stool DNA test detected 87 percent of curable-stage colorectal cancer. Importantly, detection sensitivity was not affected by tumor location or stage.
  • The test detected the majority of large precancerous polyps at high risk for cancer progression.
  • Sensitivity was 64 percent for polyps larger than 1 centimeter (cm), 77 percent for those larger than 2 cm and 92 percent for those larger than 4 cm.

"These data illustrate the strength of the multi-marker stool DNA test to the critical screening targets -- pre-cancers and early-stage cancer," says co-investigator Stephen Thibodeau, Ph.D., a genetics researcher at Mayo Clinic." And, importantly, this test appears to uniquely represent an accurate noninvasive approach to large polyp detection, which offers the promise of actually preventing cancers from developing."

Second Publication Compares Screening Methods

The second article, titled "Stool DNA vs. Plasma Septin 9 Testing," uses the results of the first study to compare the sensitivities of the stool DNA test and a plasma test for methylated Septin 9 (SEPT9) in identifying patients with large adenomas or colorectal cancer. Highlights include:

  • The stool DNA test detected 82 percent of precancerous polyps compared to only 14 percent detected by SEPT9.
  • The stool DNA identified 87 percent of cancers at any stage, compared to 60 percent with SEPT9.
  • Stool DNA was even more effective at detecting curable-stage cancer (Stage I, II or III), detecting such cases 91 percent of the time, compared to just 50 percent w
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Contact: Brian Kilen
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

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