Navigation Links
New test may predict spread of breast cancer
Date:3/24/2009

exposed to chemotherapy or radiation, which can have significant side effects or even worsen the disease, says Dr. Condeelis.

Recently, Dr. Condeelis found that breast cancer spreads only when a specific trio of cells are present together in the same microanatomic site: an endothelial cell (a type of cell that lines the blood vessels), a perivascular macrophage (a type of immune cell found near blood vessels), and a tumor cell that produces Mena. The protein Mena was shown to enhance a cancer cells invasiveness in a collaborative study from Dr. Condeelis and Frank Gertler at the Koch Institute for Integrative Cancer Research at MIT published in Developmental Cell in December. A site with these three cells constitutes what is called a tumor microenvironment of metastasis, or TMEM.

The NewYork-Presbyterian/Weill Cornell investigators, aided by the Einstein and MIT scientists, then developed a tissue test to detect the presence and density of TMEMs. The test consists of a triple immunostain containing antibodies to the three cell types. A high number of TMEMs in a tissue sample means that the tumor is likely to metastasize or has already done so. In the current study, the immunostain was tested on breast tissue biopsy samples taken from 30 patients with advanced metastatic breast cancer and 30 patients with localized breast cancer, all of whom had been followed for at least five years. The resulting immunostains were evaluated by two pathologists who were not aware of the patients clinical outcomes.

Their analysis confirmed that TMEM density was significantly higher in patients who had developed metastatic breast cancer than in those who had localized disease. For every ten-unit increase in TMEM density, the risk for metastatic disease doubled. The density of any of three TMEM components alone was not sufficient to predict clinical outcome.

The study also showed that the ability of the TMEM density test to predict metastatic disease was indep
'/>"/>

Contact: Deirdre Branley
dbranley@aecom.yu.edu
718-430-2923
Albert Einstein College of Medicine
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. How to predict post-operative enteral nutrition problems
2. 2-day results predict ultimate response to therapy in chronic hepatitis C
3. Abnormal EKG can predict death in stroke patients
4. Pregnant? Curious About the Babys Gender? Know if Its a Boy or Girl at Six Weeks With IntelliGenders(R) In-Home Gender Prediction Test(TM) Now Available at All Walgreens Stores
5. Leading Healthcare Organizations Share Successes Realized with MEDais Predictive Analytics
6. A simple balance test may predict cognitive decline in Alzheimers disease
7. Simple Test Helps Predict Heart Attack Risk
8. Water method for unsedated colonoscopy; interval between prep and colonoscopy predicts prep quality
9. Girls Anti-Social Behavior Predictive of Later Depression
10. Risk Score May Predict Abnormal Heart Rhythm
11. Alzheimers Association Releases Report That Predicts Doubling in Number of Californians With Neurological Disorder
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New test may predict spread of breast cancer
(Date:1/22/2015)... Jolla, Calif. (PRWEB) January 22, 2015 ... Assemblymembers Susan Bonilla (D-Concord) and Kristin Olsen (R-Modesto) ... for their leadership in advancing biotechnology, biomedical science, ... Bonilla and Olsen each received the “2014 Life ...
(Date:1/22/2015)... Four years since the release of their debut ... the marriage of Avasa & Matthew Love – the duo are ... for release through White Swan Records on February 24, 2015. , ... sacred path available to all of us to walk out of ...
(Date:1/22/2015)... As interest in the value of spiritual ... worldwide, Rev. Eric J. Hall , president and CEO ... will be the keynote speaker on January 27 at an ... system. , The conference, “Hope and Resilience: Innovative and Interdisciplinary ...
(Date:1/22/2015)... 2015 Lower-Auto-Insurance.com has released a new blog post ... car for reducing the costs of an auto insurance policy ... able to get lower prices for their vehicle insurance policies. The ... in determining policy costs. Because of this, drivers should always ...
(Date:12/26/2014)... The US represents the largest market for ... GlobalData’s forecast estimates that sales of branded therapies were $2.23 ... the high incidence of the disease, high drug treatment rate, ... China. Increased sales of CRC therapies over the forecast period ...
Breaking Medicine News(10 mins):Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 2Health News:THE ROAD by Avasa & Matthew Love -- A New Album 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 4Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 2Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 3Health News:Driving Safe And Other Factors That Make Auto Insurance Affordable! 2Health News:US Colorectal Cancer Drug Market Analysis and Forecast to 2023 Report Available at ReportsnReports.com 2Health News:US Colorectal Cancer Drug Market Analysis and Forecast to 2023 Report Available at ReportsnReports.com 3Health News:US Colorectal Cancer Drug Market Analysis and Forecast to 2023 Report Available at ReportsnReports.com 4
... Haneef, the man from Bangalore in southern India, continues . ... a small act of indiscretion, it looks like. He had allowed ... players in the failed Glasgow bombing. ,Intercepted when he ... the Glasgow incident, Haneef has been seeing his hopes soar only ...
... can more than double the risk of developing kidney cancer ... is a repeated loss and gain of body weight due ... aged between 50 and 79 for almost eight years to ... waist size to those with the large waistlines. ...
... chain 'PizzaExpress' has been named the most vegan-friendly food chain ... by the animal rights group for its cheese-free pizzas, the ... organisations recognised by PETA for 'animal-friendly progress'. ... and the first restaurant was opened in Wardour Street in ...
... fast food joint in Miami, Florida . ,The ... revealed that she has been hooked to the idea of ... ,"That was part of my L.A. education - on Sundays ... (cars)... FatBurger was, like, the centrepiece for it all," Contactmusic ...
... Combining medicines with the right food could improve the ... costs of treating patients, experts say . ... Ezra Cohen, MD, have released their expert comments after ... with fatty food, rather than on an empty stomach, ...
... the Varanavasi Village Panchayat near Kanchipuram in Tamil Nadu ... . ,Aghast over an ever-increasing trend of ... to ban the entry and consumption of tobacco products. ... consuming tobacco products like cigarette and gutka. Hence, the ...
Cached Medicine News:Health News:Haneefs Visa Revoked by Australia 2Health News:Right Foods Could Improve Drug Effectiveness, Lower Drug Costs 2Health News:Village Panchayat in Tamil Nadu Bans Tobacco Consumption 2
(Date:1/22/2015)... Therapeutics Inc. (OTCQX:PVTTF; CSE:PVO), ("Pivotal" or the "Company"), a specialty ... disease and overall health is pleased to provide you with ... outlook for 2015 from the CEO, Mr. Eugene Bortoluzzi ... like to take this opportunity to share with you the ...
(Date:1/22/2015)... MINNEAPOLIS , Jan. 22, 2015  Bio-Techne Corporation (NASDAQ: ... launched Ella, the first member of the new Simple ... ProteinSimple brand.  This launch represents the re-branding of the ... The Simple Plex platform is a transformative immunoassay technology ...
(Date:1/22/2015)... 2015 Increasing sophistication among enterprise buyers of language ... in 2015, says Moravia CMO, Renato ... by market research firm Common Sense Advisory, 15 percent ... translation and localization needs. "From a language industry perspective, ...
Breaking Medicine Technology:Pivotal Therapeutics: Year in Review and CEO Update 2Pivotal Therapeutics: Year in Review and CEO Update 3Pivotal Therapeutics: Year in Review and CEO Update 4Pivotal Therapeutics: Year in Review and CEO Update 5Pivotal Therapeutics: Year in Review and CEO Update 6Pivotal Therapeutics: Year in Review and CEO Update 7Bio-Techne Launches Simple Plex Platform 2Bio-Techne Launches Simple Plex Platform 3Moravia Sees Single-Sourcing as Key Localization Trend in 2015 2
... introduces new high precision femtosecond laser technology ... opportunity to offer their patients a safer, ... creating the corneal flap. By using ... IntraLASIK software, surgeons may avoid the complications ...
... Teco Diagnostics manufactures fine urine chemistry ... urine chemistry reagent strips from start ... offer more economical prices compared to ... quality. Teco Diagnostics urine reagent strips ...
... Long term complications associated with diabetes ... the health and quality of life of ... costs. These complications are known to be ... The discovery that the level of haemoglobin ...
The Lifestream Plus Cholesterol Monitor provides you with a comprehensive tool to help you monitor your cholesterol as part of your wellness program....
Medicine Products: