Navigation Links
New test announced for major killer of lung transplant patients
Date:12/30/2010

ANN ARBOR, Mich. A lung transplant can mean a new chance at life. But many who receive one develop a debilitating, fatal condition that causes scar tissue to build up in the lungs and chokes off the ability to breathe.

University of Michigan researchers hope a new diagnostic tool they developed to predict bronchiolitis obliterans syndrome (BOS) will allow doctors to intervene earlier and, ultimately, to provide life-saving treatments.

BOS is the leading cause of death for those who survive one year after lung transplantation and more than half of recipients will develop BOS within five years. There is currently no cure.

Vibha Lama, M.D., M.S., an assistant professor of pulmonary and critical care medicine at the University of Michigan Medical School, led a team of U-M researchers who recently discovered that patients who had a high number of stem cells in their lungs six months after transplantation were much more likely to develop BOS than those with lower counts.

"Our study provides the first indication of the important role these cells play in both human repair and disease," Lama says. "It's very important from the clinical perspective because we didn't previously have any strong biomarkers for BOS."

The findings were recently published online ahead of print publication in the American Journal of Respiratory and Critical Care Medicine.

The translational study also highlights the importance of the lab-to-bedside cooperation of basic and clinical research, Lama says.

While the exact relationship between the mesenchymal stromal cells and BOS remains unclear, doctors know that most of the cells originate with the donor and not the recipient. Spikes in cell counts are seen shortly after transplantation as the body responds to the injury; those levels usually taper off, but a second rise of cell counts after about six months is linked to a patient's likelihood of developing BOS.

In 2007, Lama and her colleagues published another discovery about the stem cells, revealing that the cells reside in the transplanted organs, independent of their more commonly known association with bone marrow. That study led to the further exploration of the cells' involvement with chronic transplant rejection.

The new findings also have the potential to spur research that will help people suffering from other types of lung disease, such as idiopathic pulmonary fibrosis, known as IPF.

Having the biomarker will also allow researchers to readily identify a population of patients ideal for testing new drug interventions and therapies.

"By the time we usually diagnose BOS, there's already been a huge decline in lung function," Lama says. "If we can find the disease early, we can potentially do something about it."


'/>"/>

Contact: Ian Demsky
idemsky@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Related medicine news :

1. Autism Consortium 2010 Symposium: New therapeutics focus, family resource guide announced
2. Popular Mechanics breakthrough awardees announced
3. MARC Travel Awards announced for the 2010 Integrative Physiology of Exercise Meeting
4. Significant advance announced in treatment of cervical cancer
5. Civil society and local partners for XIX International AIDS Conference (AIDS 2012) announced
6. State of the Art Hospital for Rural Kenya Announced by California Foundation
7. New Health Reform Law Claim Denial Appeal Book Announced for Healthcare Providers to Comply with New PPACA Deadline - 09/23/2010
8. KFx Medical Corporation Announced Today It Has Received FDA 510k Clearance for Product(s) Used in a Wide Variety of Knee Procedures
9. 2010 OTC National Advertising Award Winners Announced
10. Lumenis Announced Today it is Sponsoring the Endometriosis Foundation of America's Symposium 'Advancing the Art and Science of Endometriosis: Stem Cells to Radical Excision Surgery'
11. SIUE Pain Summit Recommendations Announced Today
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/23/2017)... ... ... Curemark, LLC announced today that the Blüm Study, a Phase 3 clinical ... Autism, is now enrolling at three new sites. These new sites are in addition ... “There are currently no approved drugs that address the core symptoms of autism,” said ...
(Date:2/23/2017)... ... February 23, 2017 , ... Carlos Gutierrez has lived his ... to spiritually evolve, which is the purpose of everyone in this universe. As Gutierrez ... (published by Balboa Press) attempts to guide readers to expand one’s spiritual life. , ...
(Date:2/22/2017)... ... February 22, 2017 , ... Gevir, a New Zealand-based company that ... its products are coming soon to Amazon.com, the world’s largest online retailer. ... means to develop an effective natural treatment for Shelley’s Multiple Sclerosis, which she’d been ...
(Date:2/22/2017)... MD (PRWEB) , ... February 22, 2017 , ... ... Direct secure messaging services to the largest network of hospitals, health information ... the National Coordinator for Health Information Technology (ONC-HIT) 2015 Edition Health IT Module ...
(Date:2/22/2017)... CRANBURY, N.J. (PRWEB) , ... February 22, 2017 ... ... than a one-size-fits-all approach, leads to fewer trips the emergency room, fewer hospital ... in The American Journal of Managed Care® (AJMC®) finds. The study can be ...
Breaking Medicine News(10 mins):
(Date:2/22/2017)... Summary Provides understanding and ... entered into by the worlds leading healthcare companies. ... Description The Global Atherosclerosis Partnering Terms and ... to partnering deals and agreements entered into by ... Trends in partnering deals - Top deals ...
(Date:2/22/2017)... Feb. 22, 2017 Summary Provides ... deals and agreements entered into by the worlds leading ... Description The Global Motor Neurone Disease Partnering ... access to partnering deals and agreements entered into by ... in partnering deals - Top deals by value ...
(Date:2/22/2017)... , February 22, 2017 ... microscopy market are Olympus Corporation, Nikon Corporation, and ... or 75% in the overall market in 2015. ... product innovation through result-oriented research and development activities ... expected to focus on expanding their business to ...
Breaking Medicine Technology: