Navigation Links
New technology using florescent proteins tracks cancer cells circulating in the blood
Date:5/8/2014

After cancer spreads, finding and destroying malignant cells that circulate in the body is usually critical to patient survival. Now, researchers reporting in the Cell Press journal Chemistry & Biology have developed a new method that allows investigators to label and track single tumor cells circulating in the blood. This advance could help investigators develop a better understanding of cancer spread and how to stop it.

Cancer spread, or metastasis, leads to up to 90% of cancer deaths. Investigators currently do not have the clinical capability to intervene and stop the dissemination of tumor cells through metastasis because many steps of this process remain unclear. It is known that cancer cells undergo multiple steps, including invasion into nearby normal tissue, movement into the lymphatic system or the bloodstream, circulation to other parts of the body, invasion of new tissues, and growth at distant locations. Now, a new approach developed by Dr. Ekaterina Galanzha of the University of Arkansas for Medical Sciences in Little Rock and her colleagues allows for labeling and tracking of individual circulating cancer cells throughout the body, thereby helping researchers elucidate the pathways of single cells from start to finish.

The advance uses photoswitchable fluorescent proteins that change their color in response to light. When the first laser of light hits the circulating tumor cells, they appear to be fluorescent green. A second laser, using a different wavelength, makes the cells appear to be fluorescent red. To label individual cells, researchers use a very thin violet laser beam aimed at small blood vessels.

The fluorescence from each cell is collected, detected, and reproduced on a computer monitor as real-time signal traces, allowing the investigators to count and track individual cells in the bloodstream

"This technology allows for the labeling of just one circulating pathological cell among billions of other normal blood cells by ultrafast changing color of photosensitive proteins inside the cell in response to laser light," explains Dr. Galanzha.

In tumor-bearing mice, the researchers could monitor the real-time dynamics of circulating cancer cells released from a primary tumor. They could also image the various final destinations of individual circulating cells and observe how these cells travel through circulation and colonize healthy tissue, existing sites of metastasis, or the site of the primary tumor. "Therefore, the approach may give oncologists knowledge on how to intervene and stop circulating cancer cell dissemination that might prevent the development of metastasis," she says.

The approach might also prove useful for other areas of medicinefor example, tracking bacteria during infections or immune-related cells during the development of autoimmune disease.


'/>"/>

Contact: Mary Beth O'Leary
moleary@cell.com
617-397-2802
Cell Press
Source:Eurekalert  

Related medicine news :

1. Tufts University licenses silk biomaterials technology to Akeso Biomedical
2. Microfluidic technology reveals potential biomarker for early pancreatic cancer
3. Airport security-style technology could help doctors decide on stroke treatment
4. Bio-Rads Droplet Digital PCR technology highlighted at the 2014 AACR Annual Meeting
5. New technology from CWRU links patient records between hospitals, medical flight crews
6. New advance in 3-D printing and tissue engineering technology
7. Pitts Center for Medical Innovation announces pilot funding for biomedical technology
8. Beaumont Health System first outside of Japan to test new atrial fibrillation technology
9. CONRAD wins USAID Science and Technology Pioneers Prize for development of first vaginal gel proven to reduce HIV
10. Global collaboration forms to advance Japanese TB vaccine technology
11. Schizophrenia in the limelight: Film-industry technology provides insights
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New technology using florescent proteins tracks cancer cells circulating in the blood
(Date:6/27/2016)... Overland Park, KS (PRWEB) , ... June 27, 2016 , ... ... leader in retailers of Eyeglasses . , Millions of individuals in the United ... life, eyeglasses have become a way to both correct vision and make a fashion ...
(Date:6/26/2016)... , ... June 26, 2016 , ... PawPaws brand ... new product that was developed to enhance the health of felines. The formula is ... The two main herbs in the PawPaws Cat Kidney Support Supplement Soft ...
(Date:6/25/2016)... ... , ... Austin residents seeking Mohs surgery services, can now turn to Dr. ... Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization to include ... in Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction of Glenn ...
(Date:6/25/2016)... , ... June 25, 2016 , ... As a lifelong ... Cum Laude and his M.D from the David Geffen School of Medicine at UCLA. ... to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... A recent ... that most people are unfamiliar with. The article goes on to state that individuals ... also many of these less common operations such as calf and cheek reduction. The ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016 Research and ... Excipients Market by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), ... Topical, Coating, Parenteral) - Global Forecast to 2021" ... The global pharmaceutical excipients market is projected ... CAGR of 6.1% in the forecast period 2016 to ...
(Date:6/23/2016)... 23, 2016 Roche (SIX: RO, ROG; OTCQX: ... its Elecsys BRAHMS PCT (procalcitonin) assay as a dedicated ... shock. With this clearance, Roche is the first IVD ... solution for sepsis risk assessment and management. ... and PCT levels in blood can aid clinicians in ...
(Date:6/23/2016)... ANGELES , June 23, 2016 ... CAPR ), a biotechnology company focused ... therapeutics, today announced that patient enrollment in its ... in Duchenne) has exceeded 50% of its 24-patient ... enrollment in the third quarter of 2016, and ...
Breaking Medicine Technology: