Navigation Links
New technology to tackle treatment-resistant cancers

Free-flowing cancer cells have been mapped with unprecedented accuracy in the bloodstream of patients with prostate, breast and pancreatic cancer, using a brand new approach, in an attempt to assess and control the disease as it spreads in real time through the body, and solve the problem of predicting response and resistance to therapies.

In comparison to a previous generation of systems, the researchers state their test showed a significantly greater number of high-definition circulating tumour cells (HD-CTCs), in a higher proportion of patients, by using a computing-intensive method that enables them to look at millions of normal cells and find the rare cancer cells among them.

Their results, published today, Friday 3 February 2012, in IOP Publishing's journal Physical Biology, could help reveal the mechanisms behind the spread of solid tumours from one organ or tissue to another mechanisms that have, until now, remained a mystery.

Dr Jorge Nieva, an oncologist at Billings Clinic leading the study, said: "This technology will allow scientists to move away from mouse and cell culture systems and speed the delivery of cures for cancer in people. This is the technology we have been waiting for to solve the problem of resistance to chemotherapy drugs."

Senior technology author of the study, Professor Peter Kuhn, said: "In the future, our fluid biopsy can effectively become the companion to the patient for life. If we can assess the disease in real time, we can make quantitative treatment decisions in real time. These decisions include predictive decisions about therapeutic response, diagnostic decisions and prognostic decisions about outcome."

The researchers, based at the Scripps Physics Oncology Center in La Jolla, California, were able to find five or more CTCs in each milliliter of blood in 80% of the 20 patients they tested with prostate cancer; 70% in the 30 patients with breast cancer; and 50% in the 18 patients with pancreatic cancer.

The authors also report that their test showed significantly better results when compared with the commercial test, CellSearch, which uses a slightly less accurate approach which effectively reduces the sample from approximately 50 million cells to just 5,000 before conducting fluorescent imaging, meaning important cells you wish to study could be lost.

In 7.5 mL of blood, the CellSearch test found two or more CTCs in 5 out of the 15 patients tested whereas the new test found two or more CTCs in a single milliliter of blood in 14 out of the 15 patients tested.

The dyes used in this new approach contain antibodies that target, and then attach to, specific proteins that are expressed by the CTCs. Once attached, they fluoresce and allow the researchers to observe them. The result is a set of high resolution digital images that retain the intricate details of the cells and allow the researchers to effectively analyse them in the laboratory. Also striking is the quality of the images.

"The high definition method gives a detailed portrait of these elusive cells that are caught in the act of spreading around the body. It's unprecedented we've never been able to see them routinely and in high definition like this before," says diagnostic pathologist Kelly Bethel, MD, the senior clinical investigator on Kuhn's team.

"The science behind this approach, and the ability to obtain more detailed information about CTCs in a timely fashion, opens up opportunities to address some of the outstanding problems in cancer, such as drug-resistance. This is an example that bringing a physical sciences approach to a medical need has potential for profound consequences to greatly benefit cancer patients," said Dr Larry Nagahara of the National Cancer Institute.

Contact: Michael Bishop
Institute of Physics

Related medicine news :

1. Three NHS Trusts Choose BigHand Voice Technology Under YHCPC Framework Agreement
2. Gold at Forefront of Nanotechnology Revolution
3. Human Dental Technology Leads to Breakthroughs for Pet Dental Health at Sergeants Pet Care Products, Inc.
4. Embark Health Selects the Jellyvision Lab's Interactive Conversation Technology to Educate Website Visitors on Advance Directives
5. First Breakthrough in Water Heating Technology!
6. New Technology Could Widen Reach of Vaccines
7. WebMD to Present at the Goldman Sachs Technology and Internet Conference 2010
8. Nanotechnology could help Arab region
9. Genetic health risks in children of assisted reproductive technology
10. Mennen Medical Launches the VitaLogik 6000, a Pre-Configured Multi-Parameter Patient Monitor with New High Performance Wireless Technology
11. New cardiac CT technology drastically reduces patient radiation exposure
Post Your Comments:
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture ... said Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package ... Final Cut Pro X . Simply select a ProHand generator and drag it ...
(Date:6/25/2016)... Montreal, Canada (PRWEB) , ... June 25, 2016 , ... ... the pursuit of success. In terms of the latter, setting the bar too high ... low, risk more than just slow progress toward their goal. , Research from ...
(Date:6/24/2016)... Dallas, Texas (PRWEB) , ... June 24, 2016 ... ... 12th International Conference and Scientific Sessions in Dallas that it will receive two ... Announcement of the grants came as PHA marked its 25th anniversary by recognizing ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are sharpening their pencils ... an essay contest in which patients and their families pay tribute to a genetic ... 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. ...
(Date:6/24/2016)... ... June 24, 2016 , ... National recruitment firm Slone Partners ... extensive sequencing and genomics experience, as Vice President of North American Capital Sales at ... responsible for leading the sales team in the commercialization of the HTG EdgeSeq system ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 ... of the "Structural Electronics 2015-2025: Applications, Technologies, ... In-Mold Electronics, Smart Skin, ... Photovoltaics Structural electronics involves electronic ... load-bearing, protective structures, replacing dumb structures such as ...
(Date:6/24/2016)... India , June 24, 2016 ... Needles Market by Type (Standard Pen Needles, Safety Pen ... Therapy (Insulin, GLP-1, Growth Hormone), Mode of Purchase (Retail, ... by MarketsandMarkets, This report studies the market for the ... expected to reach USD 2.81 Billion by 2021 from ...
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... "Dialysis Devices Global Market - Forecast to 2022" report ... is the treatment method for the patients with kidney failure, ... and excess fluid from the patient,s blood and thus the ... sodium, potassium and chloride in balance. Increasing ...
Breaking Medicine Technology: