Navigation Links
New technology simplifies production of biotech medicines
Date:5/14/2014

The final step in the production of a biotech medicine is finishing with the correct sugar structure. This step is essential for the efficacy of the medicine, but it also makes the production process very complex and expensive. Leander Meuris, Francis Santens and Nico Callewaert (VIB/UGent) have developed a technology that shortens the sugar structures whilst retaining the therapeutic efficiency. This technology has the potential to make the production of biotech medicines significantly simpler and cheaper.

Sugar structures are essential for the mechanism of biotech medicines

Nearly all biotech medicines are proteins. Most of these medicines contain a mixture of complicated sugar structures that are attached to the protein. These sugars are important for the mechanism of the medicine on the one hand, but on the other hand their complicated structure also causes problems during production. This makes the process expensive and often results in a mixture of the same protein with different sugars attached. In some cases, only a few of the many sugar forms are ideal for the treatment and others are not, meaning that a part of the production and treatment efficiency is lost.

Optimizing production cells

The proteins that are used as biotech medicines are produced by living cells. Leander Meuris and Nico Callewaert have altered these production cells so that they truncate the sugar structures to a smaller shape. In order to achieve this they added an enzyme obtained from a fungus, which truncates complex sugars, to the production cells. The stump that remains after truncation is then expanded by the cells to form two similar structures that are very suitable for therapeutic applications. Surprisingly, these production cells do not mind: they grow perfectly and continue to produce the therapeutic proteins.

A satisfying discovery

Nico Callewaert (VIB/UGent): "This technology has allowed us to solve an old bio
'/>"/>

Contact: Sooike Stoops
info@vib.be
32-924-46611
VIB (the Flanders Institute for Biotechnology)
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Mechanical tissue resuscitation technology shows promise
2. New study identifies how information technology is used to solve global health challenges
3. Power generation technology based on piezoelectric nanocomposite materials developed by KAIST
4. Simulation technology allows users to safely practice phacoemulsification cataract surgery
5. The Casey Group's Sales Navigator Wins 2012 Best Mobility App in the New Jersey Technology Council's Mobile Application Competition
6. Swanson Health Products Introduces a New Alkalizing Drink Mix, Swanson® pH Balance Alka-Tone with Alka-Plex™ Technology
7. Miami Children’s Hospital Performs First Nerve Repair Surgery Using Avance® Nerve Graft Technology
8. FDA Approves SonixGPS Needle Guidance Technology for Vascular Access Procedures
9. IVR Technology Group Named Platimum VAR by TSYS
10. 3M™ Gripping Material Technology – Giving Golfers a Competitive Edge
11. Newer technology to control blood sugar works better than conventional methods
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/15/2014)... September 15, 2014 Insurers across ... that bring providers on board as partners to ... When bundled payment programs are designed properly they ... incentivize hospitals to work collaboratively with providers, and ... On Sept. 24, the Atlantic Information Services webinar, ...
(Date:9/15/2014)... With a simple swab of the cheek, the ... to help personalize the treatment for patients with vascular disorders, ... approach to medicine is preventive care. But, it can be ... respond to specific drugs. A simple cheek swab test can ... physician to tailor medical therapy and optimize outcomes. , “By ...
(Date:9/15/2014)... 2014 AttorneyOne.com, a recognized authority on ... information from the FDA on sterile drug products ... FDA, the Agency announced on September 9, that it ... recall of all lots of its purportedly ... expired due to lack of sterility assurance. , In ...
(Date:9/15/2014)... Fancyflyingfox.com, the distinguished wedding dress manufacturer and ... beach wedding dresses . All clients can enjoy a ... up to 70 percent off. According to the company’s ... its loyal customers by launching the current sale. ... 300 different styles of special occasion gowns are provided. ...
(Date:9/14/2014)... 2014 Skin becomes dryer with age. Some ... and not moisturizing properly. However, there are inevitable internal factors ... for. , Two main reasons this occurs: , 1) Loss ... in the skin , During the aging process, skin produces ... responsible for important moisture retention and radiance of skin. ...
Breaking Medicine News(10 mins):Health News:Sept. 24 Webinar to Profile Geisinger Health System, BCBS of North Carolina’s Successful Bundled-Payment Programs 2Health News:Center for Vascular Medicine Offers Genetic Testing For Personalized Vascular Care 2Health News:FDA Requests Recall of Sterile Drug Products by Downing Labs (aka NuVision Pharmacy): AttorneyOne Monitors and Keeps Consumers Informed 2Health News:Great Discounts On Beach Wedding Dresses Announced By Fancyflyingfox.com Now 2Health News:2 Reasons Skin Becomes Dryer with Age and What To Do About It, From Sublime Beauty® 2Health News:2 Reasons Skin Becomes Dryer with Age and What To Do About It, From Sublime Beauty® 3
... when added to existing meds, study finds , , ... helps relieve neuropathic pain in people with HIV, ... of Medicine study. , It included 28 HIV ... by opiates or other pain relievers. The researchers ...
... Increases 2008 Net Sales Projections; Affirms Top End of Adjusted* ... Earnings Guidance --, ... global specialty pharmaceutical and medication,delivery company, today reported results for the second quarter ... during the second quarter of 2008, compared to $869.3 ...
... Inclusion for Key, Emerging Biologic Agents That Will Launch ... Years, According to a ... 6 Decision Resources, one of the,world,s leading research ... 89 percent of surveyed rheumatologists,anticipate prescribing Roche/Chugai,s Actemra, following ...
... Aduromed Begins Next Step in Corporate Evolution, Restructuring the Company ... and Augmenting its Board and Management Team, ... Board: ADRM) a leading manufacturer of medical waste,treatment systems, today ... raise of $3.8 million of new equity capital. As,part of ...
... Software, Inc. today,announced the worldwide launch of iFastrack, ... software for reducing business,risk by tracking insurance certificates ... to manage their risk from,uninsured contractors, vendors or ... proof of insurance at the onset of a ...
... Increase Revenues by Up to $2 Million This ... Corporation (OTC,Bulletin Board: BDRR), a medical imaging and ... Imaging, Inc. has entered into,a joint venture (JV) ... Basic Solutions, Inc. will offer mobile cardiac stress ...
Cached Medicine News:Health News:Medicinal Marijuana Eases Neuropathic Pain in HIV 2Health News:Hospira Reports Second-Quarter 2008 Results 2Health News:Hospira Reports Second-Quarter 2008 Results 3Health News:Hospira Reports Second-Quarter 2008 Results 4Health News:Hospira Reports Second-Quarter 2008 Results 5Health News:Hospira Reports Second-Quarter 2008 Results 6Health News:Hospira Reports Second-Quarter 2008 Results 7Health News:Hospira Reports Second-Quarter 2008 Results 8Health News:Hospira Reports Second-Quarter 2008 Results 9Health News:Hospira Reports Second-Quarter 2008 Results 10Health News:Hospira Reports Second-Quarter 2008 Results 11Health News:Hospira Reports Second-Quarter 2008 Results 12Health News:Hospira Reports Second-Quarter 2008 Results 13Health News:Hospira Reports Second-Quarter 2008 Results 14Health News:Hospira Reports Second-Quarter 2008 Results 15Health News:Hospira Reports Second-Quarter 2008 Results 16Health News:Hospira Reports Second-Quarter 2008 Results 17Health News:Hospira Reports Second-Quarter 2008 Results 18Health News:Hospira Reports Second-Quarter 2008 Results 19Health News:Hospira Reports Second-Quarter 2008 Results 20Health News:Hospira Reports Second-Quarter 2008 Results 21Health News:Hospira Reports Second-Quarter 2008 Results 22Health News:Hospira Reports Second-Quarter 2008 Results 23Health News:Hospira Reports Second-Quarter 2008 Results 24Health News:Hospira Reports Second-Quarter 2008 Results 25Health News:Hospira Reports Second-Quarter 2008 Results 26Health News:Hospira Reports Second-Quarter 2008 Results 27Health News:Hospira Reports Second-Quarter 2008 Results 28Health News:Eighty-Nine Percent of Surveyed Rheumatologists Say They Will Prescribe Roche/Chugai's Actemra for Rheumatoid Arthritis 2Health News:Eighty-Nine Percent of Surveyed Rheumatologists Say They Will Prescribe Roche/Chugai's Actemra for Rheumatoid Arthritis 3Health News:Aduromed Closes Restructuring and Raises $3.8 Million of New Equity Capital 2Health News:Aduromed Closes Restructuring and Raises $3.8 Million of New Equity Capital 3Health News:GG-One Software Announces iFastrack to Help Avoid Insurance Disasters 2Health News:Bederra Corp.'s Lumar Imaging Division Enters Into Joint Venture With Basic Solutions 2
(Date:9/15/2014)... LONDON , BERLIN and ... The global market has the potential to grow to ... leading provider of market research reports has announced pharma industry ... Esophageal Cancers to 2019 - Crowded Late-Stage Pipelines and Favorable ... in terms of US pricing structures and the anticipated approval ...
(Date:9/15/2014)... GENEVE , September 15, 2014 /PRNewswire/ ... des principaux fabricants européens de sortir ou ... marché ou au soutien réglementaire de la ... alcaloïdes tropaniques comme principes pharmaceutiques actifs (API), ... la nortropine, le méthylbromure d,homatropine, le bromhydrate d,homatropine, ...
(Date:9/14/2014)... DIEGO , Sept. 14, 2014 HUYA ... global development of China,s pharmaceutical ... Institute of Pharmaceutical Research (TIPR) to develop medical ... and the western world, for global markets. ... venture, to be known as TIPR-HUYA Advancing Innovative Medicines ...
Breaking Medicine Technology:Monoclonal Antibodies Market for Gastric and Esophageal Cancers to Double by 2019 2Monoclonal Antibodies Market for Gastric and Esophageal Cancers to Double by 2019 3Alchem International s'engage à poursuivre et étendre la production des principes pharmaceutiques actifs contenant des alcaloïdes tropaniques et à soutenir la réglementation pour combler l'écart d'approvisionnement 2Alchem International s'engage à poursuivre et étendre la production des principes pharmaceutiques actifs contenant des alcaloïdes tropaniques et à soutenir la réglementation pour combler l'écart d'approvisionnement 3HUYA Bioscience International and TIPR Announce Joint Venture to Develop Medical Innovation for Global Markets 2HUYA Bioscience International and TIPR Announce Joint Venture to Develop Medical Innovation for Global Markets 3HUYA Bioscience International and TIPR Announce Joint Venture to Develop Medical Innovation for Global Markets 4
... (Nasdaq: ARAY ), the premier radiation ... Especialidad in Monterrey, Mexico has starting treating patients with ... is the first center in Mexico now offering patients ... anywhere in the body. The CyberKnife System ...
... Jan. 17, 2012  Ventana Medical Systems, Inc. (Ventana), ... that it has entered into a strategic collaboration ... a molecular companion diagnostic test intended to identify ... Bayer antibody-drug conjugate (ADC). Ventana,s diagnostic immunohistochemistry platform ...
Cached Medicine Technology:First CyberKnife Robotic Radiosurgery System Goes Live in Mexico 2First CyberKnife Robotic Radiosurgery System Goes Live in Mexico 3First CyberKnife Robotic Radiosurgery System Goes Live in Mexico 4Ventana Medical Systems, Inc. to Collaborate with Bayer on Companion Diagnostic Test for New Biological Cancer Therapy 2Ventana Medical Systems, Inc. to Collaborate with Bayer on Companion Diagnostic Test for New Biological Cancer Therapy 3
The ImagingPlanet 55 mm Surgical Microscope Adapter. Superior optical quality and precise engineering make this 55mm focal length adapter an excellent decision for use with your Zeiss surgical micro...
The ImagingPlanet 70 mm Surgical Microscope Adapter. Superior optical quality and precise engineering make this 70 mm focal length adapter an excellent decision for use with your Leica surgical micr...
... Manage and Retrieve a ... DVMR- office, the first digital ... the physician's office environment. DVMR ... of high-resolution cameras for simple ...
Research Grade Microscope Camera from ImagingPlanet Research Microscopy Group, a superior imaging technology that delivers increased image resolution and precise color accuracy at an affordable pric...
Medicine Products: