Navigation Links
New technique reveals cross-talk between 2 essential cellular processes
Date:7/19/2012

LA JOLLA, CA Scientists at The Scripps Research Institute have simultaneously mapped two of the most important types of protein-modification in cells, revealing their extensive cooperation during an essential cellular process.

Phosphorylation, the attachment of a phosphate group to a protein, and proteolysis, the cleavage of a protein, had almost always been studied independently. The new research combines techniques for mapping these events across all proteins in a cell population to show how they work together to execute the cellular "auto-destruct program" known as apoptosis.

The specific findings on apoptosis may lead to the development of new cancer diagnostics and drugs, since cancer treatments often aim to induce apoptosis in malignant cells. Even more importantly, the study marks the development of a basic new tool of "proteomics"the large-scale study of proteinsthat should provide useful insights into many cellular processes.

"Detecting the cross-talk between protein regulation pathways has long been a challenge, and so with this new technique we can start to do analyses that were difficult or impossible before," said Benjamin F. Cravatt, professor and chair of the Department of Chemical Physiology at Scripps Research, and member of Scripps Research's Skaggs Institute for Chemical Biology. Cravatt was the senior investigator for the study, published in the July 20, 2012 edition of the journal Cell.

Need for a Global Approach

Phosphorylation and proteolysis are among the most important mechanisms of protein modification in cells. They are mediated by enzymes, and occur after a protein has been translated from genetic material and folded. Some proteolysis and phosphorylation events serve to activate a protein so that it can take part in a purposeful cellular process; others have the effect of deactivating a protein.

Previous studies of phosphorylation and proteolysis had suggested
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
Scripps Research Institute
Source:Eurekalert  

Page: 1 2 3 4

Related medicine news :

1. New MRI technique may predict progress of dementias
2. Detecting malaria early to save lives: New optical technique promises rapid and accurate diagnosis
3. New technique may help severely damaged nerves regrow and restore function
4. New Techniques May Improve Infant Heart Surgery
5. New surgical technique for removing inoperable tumors of the abdomen
6. New technique predictably generates complex, wavy shapes
7. Screening for breast cancer without X-rays: Lasers and sound merge in promising diagnostic technique
8. A marker in the lining of the lungs could be useful diagnostic technique for lung cancer screening
9. New technique could reduce number of animals needed to test chemical safety
10. Technique spots disease using immune cell DNA
11. Noninvasive imaging technique may help kids with heart transplants
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New technique reveals cross-talk between 2 essential cellular processes
(Date:12/25/2014)... When head lice hits a home or school, parents ... rid of it while keeping it from taking over the ... the solution right in their neighborhood: Lice Troopers . ... full spectrum head lice screening and treatment services to families ... Biscayne, Brickell, Coconut Grove, Kendall, Pinecrest and South Miami. , ...
(Date:12/25/2014)... 25, 2014 (HealthDay News) -- The risk of burns ... so you need to be extra cautious, an expert ... see a significant increase in patients coming in with ... Suffolk County Volunteer Firefighters Burn Center of Stony Brook ... be full of joy, but if not careful, could ...
(Date:12/25/2014)... Dennis Thompson HealthDay ... Researchers could be closing in on a "fountain of youth" ... the health of older adults, a new study suggests. ... given a drug that targets a genetic signaling pathway linked ... Novartis report. The experimental medication, a version ...
(Date:12/25/2014)... “ SmileStix ” was featured on NewsWatch as part ... mobile applications on the iOS, Android, and Windows markets. Andrew ... the app review and shared with viewers how this is ... old saying goes, “A picture says a thousand words.” It’s ... a single image, because each picture holds a unique and ...
(Date:12/25/2014)... 25, 2014 Each year trauma accounts ... million hospital admissions across the nation (according to ... CDC’s National Hospital Ambulatory Medical Care Survey ... conducted in 2010. They estimated that there were between ... in a primary diagnosis of broken bone or fracture. ...
Breaking Medicine News(10 mins):Health News:Coral Gables Florida Gets Ready to Be Lice-Free with Lice Troopers 2Health News:Don't Let Burns Mar Your Holidays 2Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 2Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 3Health News:An Application to Create Custom Stickers was Featured on NewsWatch Television on December 19, 2014 2Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 2Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 3Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 4
... that a commonly available antibiotic can improve the quality ... also generate significant health care savings. , Results of ... and Critical Care Medicine, a top international journal, indicate ... conjunction with current asthma treatment. , The study was ...
... many preventable -- were diagnosed this year, American Cancer Society ... continues to cut a deadly swath across the globe, with ... malignancy diagnosed worldwide in 2007, with 7.6 million people dying ... & Figures , finds that 5.4 million of those cancers ...
... Incisionless surgery is the,most significant advancement in surgical ... a wide variety of academic and private hospitals ... procedures already,performed globally. Despite the fact that both ... over 50 U.S. centers,have already been trained to ...
... Data Also Underscores Dissatisfaction with Treatment Experience, ... of Internet as Informational Resource -, SAN ANTONIO, ... metastatic breast cancer (MBC) is as important as the ... a,survey presented here today at the 30th Annual San ...
... − Two studies from Mayo Clinics site in Jacksonville, ... brain, have found that women whose tumors do not ... outcomes. Because of this, these patients should be treated ... a metastasis, say the investigators, who presented their findings ...
... Dec. 15 From eliminating pain to,improving an ... attention these days., Gone is the time ... cleaning or pulling of the teeth, according to ... the Journal of the American Veterinary Medical,Association. Today, ...
Cached Medicine News:Health News:Antibiotic treatment targets difficult asthma 2Health News:Cancer Killed Almost 8 Million Worldwide in 2007 2Health News:Cancer Killed Almost 8 Million Worldwide in 2007 3Health News:Cancer Killed Almost 8 Million Worldwide in 2007 4Health News:EndoGastric Solutions Opens Three Training Centers to Keep Up with Demand from Surgeons Wanting to Learn StomaphyX(TM) Procedures 2Health News:EndoGastric Solutions Opens Three Training Centers to Keep Up with Demand from Surgeons Wanting to Learn StomaphyX(TM) Procedures 3Health News:EndoGastric Solutions Opens Three Training Centers to Keep Up with Demand from Surgeons Wanting to Learn StomaphyX(TM) Procedures 4Health News:New Survey Underscores Importance of Psychosocial and Educational Needs Among Women with Advanced Breast Cancer 2Health News:New Survey Underscores Importance of Psychosocial and Educational Needs Among Women with Advanced Breast Cancer 3Health News:Survival shortened when ER/PR negative breast cancer spreads to the brain 2Health News:Survival shortened when ER/PR negative breast cancer spreads to the brain 3Health News:Veterinary Dentistry Opens Wide 2
(Date:12/24/2014)... YORK and LONDON , ... global orthopedic industry are expected to grow at an ... in terms of value and volume. Hip, knee and ... developed world while in emerging economies they have a ... rates are challenging the use of composites. Non-metallic orthopedic ...
(Date:12/24/2014)... , December 24, 2014 ... on Global Disposable Syringe Industry of 178 ... online business intelligence library. The ... Syringe Industry is a professional and deep ...  For overview analysis, the report introduces Disposable ...
(Date:12/24/2014)... Tianyin Pharmaceutical Co., Inc. (NYSE MKT: ... biopharmaceutical, modernized traditional Chinese medicine (mTCM), branded generics ... the Company achieved the Public Notice (Gong Shi) ... of TPI,s Qionglai Facility (QLF) from the China ... period is a significant procedure of GMP certification ...
Breaking Medicine Technology:Use of Composites in Orthopedic Industry to Reach $596 Million by 2020 2Use of Composites in Orthopedic Industry to Reach $596 Million by 2020 3World Disposable Syringe Market 2014 Report: China and Regional Analysis 2World Disposable Syringe Market 2014 Report: China and Regional Analysis 3World Disposable Syringe Market 2014 Report: China and Regional Analysis 4World Disposable Syringe Market 2014 Report: China and Regional Analysis 5TPI QLF Achieved Public Notice Status of GMP Certification 2TPI QLF Achieved Public Notice Status of GMP Certification 3
The IDENTI-PRINT II ID system functions as a complete, hospital wide patient identification system. It integrates the benefits of bedside labeling into a multipurpose ID band that consolidates admitt...
... is an optional component that extends ... and difficult environments. AeroScout Location Receivers ... capabilities packaged in small, easy to ... The Location Receiver receives transmissions and ...
... VerdaSees Navigaton™ software facilitates real ... of two modules: the first module ... RFID reader devices and the database ... the second module is the user ...
... VerdaSee Patient Bracelet-ID™ provides a solution ... personnel to elopement or unauthorized movement ... issues are a key concern. Certain ... care, Alzheimer's victims, patients with highly ...
Medicine Products: