Navigation Links
New technique reduces tobacco smoke damage to lungs in mice
Date:3/17/2010

for the presence of inflammatory cells.

"We found that anti-GM-CSF strongly reduced the number of potentially harmful white blood cells that infiltrate the lung after smoke exposure, as well as inhibiting the pro-inflammatory cytokine tumor necrosis factor (TNF)-, the chemokine macrophage inflammatory protein-2 (MIP-2), which coordinates the movement of white blood cells into the lung. It also inhibited the protease MMP-12, which is known as one of the main enzymes able to destroy lung tissue," said lead researcher on the study, Ross Vlahos, Ph.D., a senior research fellow with the lung disease research group at the University of Melbourne. "Cigarette smoke-exposed mice that were treated with an anti-GM-CSF had significantly less lung inflammation in comparison to untreated mice. This indicates that GM-CSF is a key mediator in smoke-induced lung inflammation and its neutralization may have therapeutic implications in diseases such as COPD."

These results, though preliminary, may illuminate a new pathway toward fighting smoke-related disease, specifically COPD. "Short-term models often translate into benefits in longer-term models. We still need to develop new methods and agents to test this idea long term and we also need to learn if it is effective in reversing longstanding disease," explained Dr. Vlahos.

In future research, Dr. Vlahos hopes to test whether GM-CSF could be a key target in other disease processes. "We want to understand exactly how blocking GM-CSF alters disease processes at the cellular and molecular levels so we can use this fine detail to make other treatments."

But this research is no free pass for patients to continue smoking, he warned: "Our treatment deals with cigarette smoke-induced lung inflammation involved in COPD, not cancer and other smoking-related ailments. Quitting remains the best and only cure for smoking-related lung disease."


'/>"/>

Contact: Keely Savoie
ksavoie@thoracic.org
212-305-8620
American Thoracic Society
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New cancer drug screening technique more closely mirrors reality
2. Non-drug techniques reduce pain in hospitalized patients
3. Freezing Technique May Stop Breast Cancer
4. New Study Tunes Into Latest Lipo Technique
5. New DNA technique leads to a breakthrough in child cancer research
6. The Future of Cosmetic Dermatology: Leading Dermatologist Dr. David Goldberg Discusses the Latest Facial Rejuvenation Techniques
7. The New Liposuction Technique Means No Surgery or Suction
8. New Study Demonstrates Novel Use of Metabolic Imaging to Locate Sperm in Infertile Men -- Non-Invasive Imaging Procedure May Replace Invasive Techniques such as Testicula
9. Survey finds many surgeons suffer injuries from minimally invasive techniques
10. Promising new neuroimaging techniques for early detection of Alzheimers disease
11. Sanford Heart Hospital Physicians Again Recognized Internationally for Innovative Techniques
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2014)... 01, 2014 The European gas chromatography systems ... analysis and forecast of revenue. The gas chromatography systems market ... is estimated to grow to around $247.6 million by 2018, ... Browse through the TOC of the European gas chromatography systems ... This also provides a glimpse of the segmentation of gas ...
(Date:8/1/2014)... According to a new market research report of ... Types, Applications (Automotive, Petrochemical, Consumer Utility, Glass, and Aerospace ... - Analysis & Forecast to 2010 - 2020", published ... to $1.42 Billion by 2020 at a CAGR of ... grow to $238.17 Million by 2020 at a CAGR ...
(Date:8/1/2014)... Society of America (GSA) the nation,s ... aging has chosen J. Jill Suitor, PhD, ... the Distinguished Career Contribution to Gerontology Award. , ... individual whose theoretical contributions have helped bring about ... original and elegant research designs addressing a significant ...
(Date:8/1/2014)... of America (GSA) the nation,s largest ... has chosen Madonna Harrington Meyer, PhD, of ... University of Luxembourg; and Philipp Hessel, MA, MSc, ... of Economics and Political Science as the 2014 ... , These distinguished honors recognize insightful and innovative ...
(Date:8/1/2014)... August 01, 2014 Lifeinsurancenomedicalexam.info has ... life insurance for clients who have high cholesterol levels. ... still find and qualify for no medical exam life ... requiring any background medical check-ups. , Since there are ... cholesterol level will qualify in just a few minutes. ...
Breaking Medicine News(10 mins):Health News:European Gas Chromatography (GC) Systems Market is Expected to Reach $247.6 Million in 2018 - New Report by MicroMarket Monitor 2Health News:European Gas Chromatography (GC) Systems Market is Expected to Reach $247.6 Million in 2018 - New Report by MicroMarket Monitor 3Health News:European Gas Chromatography (GC) Systems Market is Expected to Reach $247.6 Million in 2018 - New Report by MicroMarket Monitor 4Health News:Thermocouples Market worth $1.42 Billion & High End Optical Pyrometers Market worth $ 238.17 Million by 2020 2Health News:Thermocouples Market worth $1.42 Billion & High End Optical Pyrometers Market worth $ 238.17 Million by 2020 3Health News:Thermocouples Market worth $1.42 Billion & High End Optical Pyrometers Market worth $ 238.17 Million by 2020 4Health News:Suitor to receive GSA's 2014 Distinguished Career Contribution to Gerontology Award 2Health News:Harrington Meyer, Leist, Hessel, Avendano to receive GSA's 2014 Kalish awards 2Health News:No Exam Life Insurance - Coverage for Clients Who Have High Cholesterol 2
... ... educational stories, NEW YORK, May 12 ... Gamble Pharmaceuticals (P&G), has,selected seven winners for the Celebrating UC Success ... by ulcerative,colitis. Winners, stories reflect a wide variety of experiences with,ulcerative ...
... 12 FutureScripts(R), the premier,pharmacy benefit manager in ... . The website is a valuable tool for ... find key,information about the drugs on FutureScripts, formulary, ... "The new website allows our customers to find ...
... in French . , Montreal, May 12, 2008 ... in some cases, emotional and physical pain can linger for ... Universit de Montral graduate student Emma Duerden is inviting amputees ... study. , Our main goal is to better understand why ...
... homeless youth suggests that treating substance abuse and mental health ... the streets. , Instead, researchers found that creating more opportunities ... factors in reducing homelessness. , A study of 180 ... most social stability, such as those who attended school more ...
... is Disability Insurance Awareness Month; LIFE Foundation Reviews Common, Misconceptions to Encourage ... ... Needs, ARLINGTON, Va., May 12 If you were ... yourself,financially? The results of a new survey released today by the nonprofit,LIFE ...
... uncover ... system abuse, HORSEHEADS, N.Y., May ... in 2007. With so many recipients and,providers involved, the New York State ... abuse., Over the last two years, Salient Corporation, provider of the ...
Cached Medicine News:Health News:UPDATE: Celebrating UC Success Announces Essay Contest Winners 2Health News:UPDATE: Celebrating UC Success Announces Essay Contest Winners 3Health News:UPDATE: Celebrating UC Success Announces Essay Contest Winners 4Health News:UPDATE: Celebrating UC Success Announces Essay Contest Winners 5Health News:UPDATE: Celebrating UC Success Announces Essay Contest Winners 6Health News:Pharmacy Benefit Manager FutureScripts(R) Launches New Website 2Health News:Pharmacy Benefit Manager FutureScripts(R) Launches New Website 3Health News:Homeless youth need more than treatment for substance abuse, study says 2Health News:Homeless youth need more than treatment for substance abuse, study says 3Health News:New Survey Finds Overwhelming Majority of Working Americans Not Financially Prepared for Disability, Would Rely on Sources Other than Themselves for Support 2Health News:New Survey Finds Overwhelming Majority of Working Americans Not Financially Prepared for Disability, Would Rely on Sources Other than Themselves for Support 3Health News:New Survey Finds Overwhelming Majority of Working Americans Not Financially Prepared for Disability, Would Rely on Sources Other than Themselves for Support 4Health News:Salient Corporation's Performance Management Solution Helps NY State Counties Identify Medicaid Fraud, Waste, and Abuse 2
(Date:7/31/2014)... BURLINGTON, Mass. , July 31, 2014 ... healthcare funding changes brought about by the ... both reimbursement and prescribing of pharmaceutical therapies. ... (MCOs) cover beneficiaries through new regulations and ... is occurring in the health exchanges—state-based marketplaces ...
(Date:7/31/2014)... Touro University California,s College of Pharmacy is ... recipient of a $150,000 grant by the Joseph & ... increase research and classroom space on its campus. ... study of health sciences, and will help us apply ... of our students," said Shelley Berkley , CEO ...
(Date:7/31/2014)... -- For its innovative modular Biomedical Research building in ... has earned a Modular Building Institute (MBI) 2014 Award ... categories, MBI,s contest is the commercial modular industry,s premier ... dealers, and product and service providers. ... our team," said Dan Palmer , President of ...
Breaking Medicine Technology:Health Exchanges Drive Change In MCO Strategies And Physician Prescribing Decisions; Impact On Pharma Mixed 2Health Exchanges Drive Change In MCO Strategies And Physician Prescribing Decisions; Impact On Pharma Mixed 3Health Exchanges Drive Change In MCO Strategies And Physician Prescribing Decisions; Impact On Pharma Mixed 4Touro University California Garners Grant From Long Foundation 2Art's Way Scientific Earns Prestigious Modular Building Institute Award 2Art's Way Scientific Earns Prestigious Modular Building Institute Award 3Art's Way Scientific Earns Prestigious Modular Building Institute Award 4
... Data presented today,at the Annual Congress of ... oral Factor Xa inhibitor DU-176b reduced the incidence,of ... elective unilateral hip replacement surgery. There was a,statistically ... the,observed bleeding rates were low across the groups. ...
... Bypass Surgery for Safety and ... Condition, WASHINGTON, Sept. 1 Patients with both ... will find good news in,new findings announced today from ... Interventions (SCAI). The one-year findings,of the new study indicate ...
Cached Medicine Technology:Daiichi Sankyo Announces Clinical Study Data for Oral Factor Xa Inhibitor DU-176b 2SCAI: CARDia Data Find Diabetic Patients With Complex Heart Disease Can Safely Choose PCI 2SCAI: CARDia Data Find Diabetic Patients With Complex Heart Disease Can Safely Choose PCI 3
... designed to validate HDL cholesterol plus other ... This control is compatible with most major ... Synchron and Vitros. HDL values are given ... methods: Dextran Sulfate 50,000 MW. Apolipoprotein A-1 ...
... is intended as a means ... ethanol assay methods. This ready-to-use, ... clinically significant levels of ammonia ... provided for the following instruments: ...
... This unassayed control is intended ... manual and automated assay methods ... oxalate in human urine samples. ... requiring no reconstitution. This control ...
... Microbumin is a two-level control ... Clinitek Microalbumin Reagent Strips and Roche ... also suitable for turbidimetric immunoassays using ... and DCA 2000, Cobas, Diasorin SPQ ...
Medicine Products: