Navigation Links
New technique permits development of enzyme tool kit
Date:5/10/2010

An Arizona State University graduate student, Jinglin Fu, in collaboration with Biodesign Institute researchers Neal Woodbury and Stephen Albert Johnston, has pioneered a technique that improves on scientists' ability to harness and modulate enzyme activity.

The new approach, reported in the Journal of the American Chemical Society (published recently online), could have wide applicability for designing a range of industrial catalysts, health care diagnostics and therapies centered on understanding the control of enzymatic activity.

Enzymes, key catalysts that speed up the reactions inside every cell, are critical for life. As Neal Woodbury, chief scientist the Biodesign Institute at Arizona State University notes, "all the processes that happen inside of your body, essentially without exception, are run by enzymes." Enzymes are also a prized tool in biomedical research, aiding the development of diagnostic tests and therapeutics for a range of human diseases.

But studying the role of enzymes can be tricky. One approach has been to use a specialized platform known as a microarraywhere glass slides are deposited with 10,000 protein fragments, called peptides, that are screened for their ability to react with specific enzymes and alter their activity. "On the microarray, you can screen thousands of molecules at the same time," Fu says, allowing the simultaneous monitoring of the peptide-enzyme binding and the change in enzyme activity at each spot on the array.

But there is a problem with this approach, that has so far hampered enzyme research. "When you try to monitor the chemical reaction that the enzyme catalyzes in the microarray, the molecule generated by the enzyme reaction quickly diffuses away, causing serious cross-contamination between spots on the array," Fu explains. To solve this problem, Fu applied polyvinyl alcohol (PVA)a thick, viscous and clear polymer to the microarray slide to limit the diffusion o
'/>"/>

Contact: Joseph Caspermeyer
Joseph.Caspermeyer@asu.edu
Arizona State University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New Study Demonstrates Novel Use of Metabolic Imaging to Locate Sperm in Infertile Men -- Non-Invasive Imaging Procedure May Replace Invasive Techniques such as Testicula
2. Survey finds many surgeons suffer injuries from minimally invasive techniques
3. Promising new neuroimaging techniques for early detection of Alzheimers disease
4. Sanford Heart Hospital Physicians Again Recognized Internationally for Innovative Techniques
5. Hair Cloning Not Yet Recommended by Researchers Who Developed the Technique
6. New Study: Innovative Technique Allows Male Cancer Survivors Who are Sterile from Treatment to Father Children
7. New measurement technique will help in fight against cancer
8. Shoulder Repair Technique Borrows From Cadavers
9. Researchers Use New Techniques to Assess PTSD
10. Controversial kidney transplant technique could provide lifeline for very ill patients
11. The New Liposuction Technique Means No Surgery or Suction
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2014)... NY (PRWEB) August 01, 2014 Ticket Down ... at Maple Lane Farms in Knoxville/Greenback, TN; Ingram Farms ... Whitehurst Cattle Farm in Archer/Gainesville, FL. Luke Bryan is currently ... with Lee Brice and Cole Swindell. Bryan is responsible for ... world each summer and this year, just because the summer ...
(Date:8/1/2014)... at the Institute of Bioengineering and Nanotechnology (IBN), ... Singapore (NCCS) have co-developed the first molecular test ... in kidney cancer patients. This breakthrough was recently ... top urology journal. , According to IBN ... our expertise in molecular diagnostics and cancer research, ...
(Date:8/1/2014)... CapsCanada, a leading provider of ... new K-CAPS® (HPMC capsules) manufacturing facility in Lakeshore, ... last year while experiencing growing global demand for ... “KCAPS® are currently sold in more than 60 ... to other HPMC capsules, K-CAPS® have exceptional appearance ...
(Date:8/1/2014)... Hills, CA (PRWEB) August 01, 2014 ... has found that carbohydrates may contribute to the ... genetically predisposed to the disease. The study was authored ... it, carbohydrates were found to cause intestinal cells to ... more susceptible to colorectal cancer. , “What’s interesting ...
(Date:8/1/2014)... South Jordan, Utah (PRWEB) August 01, 2014 ... selling company MonaVie, who completes its 500th week of ... paid since the company was founded in January 2005 ... 39 countries throughout the world. The company pays commissions ... HKD, HUF, ILS, JPY, MYR, MXN, NZD, PLN, USD, ...
Breaking Medicine News(10 mins):Health News:Luke Bryan Tickets at Maple Lane Farms in Knoxville, Ingram Farms in Auburn, Cross Creek Place in Tallahassee & Whitehurst Cattle Farm in Gainesville Now Available 2Health News:Luke Bryan Tickets at Maple Lane Farms in Knoxville, Ingram Farms in Auburn, Cross Creek Place in Tallahassee & Whitehurst Cattle Farm in Gainesville Now Available 3Health News:Luke Bryan Tickets at Maple Lane Farms in Knoxville, Ingram Farms in Auburn, Cross Creek Place in Tallahassee & Whitehurst Cattle Farm in Gainesville Now Available 4Health News:Taking the guesswork out of cancer therapy 2Health News:Taking the guesswork out of cancer therapy 3Health News:Carbs May Contribute to Colon Cancer 2Health News:MonaVie Records 500th Commission Week, Having Paid Out More Than $1.4B in Distributor Commissions 2
... mice has found that though they do not develop zits, ... to differentiate the cells// in the sebaceous glands that are ... sebaceous gland is formed. ,In new research, published ... Howard Hughes Medical Institute investigator at Rockefeller University, settles this ...
... review of the performance of the 14 boards against ... nutritional care finds// too little progress is being made ... had issued advice including recommendations that patients should be ... 24 hours of being admitted following concerns about the ...
... amounts of soda and sugary drinks is making the ... Hu and his colleagues at the Harvard School of ... conducted over the last 40 years. ,They ... American diet come from added sweeteners. And sweeteners in ...
... second-year students at Wake Forest University School of Medicine ... nervous system. Instead, a semi-conscious,// vomiting “patient” was rolled ... to help manage the case. ,“SimMan?,” a ... typical mannequin. The simulated patient makes realistic heart, lung, ...
... Text messages between lovers was imitated by a government AIDS ... highest HIV rates. This enraged activists// who feel it suggests ... ,Pictures of a mobile phone screen bearing text messages like ... over now, my husband is out' features in the 'Makhwapheni ...
... local newspaper, Vietnam News, inns are to be allowed to sell ... ,As a measure to reduce risks, Vietnam will allow the sales ... come into effect from Jan. 1, 2007. Presently, condom sales and ... in many of these inns. ,Apart from the prostitutes ...
Cached Medicine News:Health News:'Blimp1' Gene Linked To Oily Skin 2Health News:Computerized Patient Used to Teach Science to Medical Students 2Health News:AIDS Campaign Enrages HIV Infected Swazis 2
(Date:7/31/2014)... Pharmacyclics, Inc. (the "Company") (Nasdaq: PCYC ) today ... June 30, 2014. Financial Results for the Six ... revenue for the quarter ended June 30, 2014 increased to ... 30, 2013 primarily due to IMBRUVICA ® (ibrutinib) net ... for the six months ended June 30, 2014 increased to ...
(Date:7/31/2014)... -- UBM Medica US announces that Cancer Network ... exclusive slide shows dealing with communication in the oncology ... Cancer Network, the online home ... and podcasts about the latest clinical findings. Among the ... , End-of-life care is challenging for even the most ...
(Date:7/31/2014)... -- Touro University California,s College of Pharmacy is pleased ... of a $150,000 grant by the Joseph & Vera ... research and classroom space on its campus. ... of health sciences, and will help us apply high-tech ... our students," said Shelley Berkley , CEO and ...
Breaking Medicine Technology:Pharmacyclics Reports Second Quarter 2014 Results 2Pharmacyclics Reports Second Quarter 2014 Results 3Pharmacyclics Reports Second Quarter 2014 Results 4Pharmacyclics Reports Second Quarter 2014 Results 5Pharmacyclics Reports Second Quarter 2014 Results 6Pharmacyclics Reports Second Quarter 2014 Results 7Pharmacyclics Reports Second Quarter 2014 Results 8Pharmacyclics Reports Second Quarter 2014 Results 9Pharmacyclics Reports Second Quarter 2014 Results 10Pharmacyclics Reports Second Quarter 2014 Results 11Pharmacyclics Reports Second Quarter 2014 Results 12Pharmacyclics Reports Second Quarter 2014 Results 13Pharmacyclics Reports Second Quarter 2014 Results 14Pharmacyclics Reports Second Quarter 2014 Results 15Pharmacyclics Reports Second Quarter 2014 Results 16Pharmacyclics Reports Second Quarter 2014 Results 17Pharmacyclics Reports Second Quarter 2014 Results 18Pharmacyclics Reports Second Quarter 2014 Results 19Pharmacyclics Reports Second Quarter 2014 Results 20Pharmacyclics Reports Second Quarter 2014 Results 21Pharmacyclics Reports Second Quarter 2014 Results 22Pharmacyclics Reports Second Quarter 2014 Results 23Pharmacyclics Reports Second Quarter 2014 Results 24Pharmacyclics Reports Second Quarter 2014 Results 25Pharmacyclics Reports Second Quarter 2014 Results 26Pharmacyclics Reports Second Quarter 2014 Results 27Pharmacyclics Reports Second Quarter 2014 Results 28Cancer Network Highlights Methods Oncologists Can Use to Improve Communication 2Cancer Network Highlights Methods Oncologists Can Use to Improve Communication 3Touro University California Garners Grant From Long Foundation 2
... (OTC: HEWA) a leading VIPPS accredited retail mail-order pharmacy, ... ended September 30, 2011. In the ... increased $1,567,764 to $2,783,240, up 129% compared to the ... strength in its prescription business.  Prescriptions filled increased from ...
... Nov. 17, 2011 Cohera Medical, a rapidly growing ... selling its lead product, TissuGlu® Surgical Adhesive, to hospitals ... regional launch will document and highlight the advantages of ... expansion throughout Germany and to additional European markets in ...
Cached Medicine Technology:HealthWarehouse.com Reports 129% Quarter-Over-Quarter Revenue Growth in the Third Quarter 2011 2Cohera Medical Commercializes TissuGlu® Surgical Adhesive in Germany 2Cohera Medical Commercializes TissuGlu® Surgical Adhesive in Germany 3
The Ultima 2000 SE is flexible in meeting the needs of both office and operating room use. It is the answer for the clinical practice with a wide range of ophthalmic demands looking for minimal risk ...
Practice-oriented ophthalmic laser systems for photodisruption....
Magnetic Farnsworth D15 kit Magnets move the color disks. Protects disks from fingerprints. Keeps all the disks in one place. Clear glass insures accurate color perception. Makes color testing fun....
... D15 test is used to ... defect vs normal. Farnsworth D15 ... permit the patient to select ... the box is closed and ...
Medicine Products: