Navigation Links
New technique permits development of enzyme tool kit
Date:5/10/2010

An Arizona State University graduate student, Jinglin Fu, in collaboration with Biodesign Institute researchers Neal Woodbury and Stephen Albert Johnston, has pioneered a technique that improves on scientists' ability to harness and modulate enzyme activity.

The new approach, reported in the Journal of the American Chemical Society (published recently online), could have wide applicability for designing a range of industrial catalysts, health care diagnostics and therapies centered on understanding the control of enzymatic activity.

Enzymes, key catalysts that speed up the reactions inside every cell, are critical for life. As Neal Woodbury, chief scientist the Biodesign Institute at Arizona State University notes, "all the processes that happen inside of your body, essentially without exception, are run by enzymes." Enzymes are also a prized tool in biomedical research, aiding the development of diagnostic tests and therapeutics for a range of human diseases.

But studying the role of enzymes can be tricky. One approach has been to use a specialized platform known as a microarraywhere glass slides are deposited with 10,000 protein fragments, called peptides, that are screened for their ability to react with specific enzymes and alter their activity. "On the microarray, you can screen thousands of molecules at the same time," Fu says, allowing the simultaneous monitoring of the peptide-enzyme binding and the change in enzyme activity at each spot on the array.

But there is a problem with this approach, that has so far hampered enzyme research. "When you try to monitor the chemical reaction that the enzyme catalyzes in the microarray, the molecule generated by the enzyme reaction quickly diffuses away, causing serious cross-contamination between spots on the array," Fu explains. To solve this problem, Fu applied polyvinyl alcohol (PVA)a thick, viscous and clear polymer to the microarray slide to limit the diffusion o
'/>"/>

Contact: Joseph Caspermeyer
Joseph.Caspermeyer@asu.edu
Arizona State University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New Study Demonstrates Novel Use of Metabolic Imaging to Locate Sperm in Infertile Men -- Non-Invasive Imaging Procedure May Replace Invasive Techniques such as Testicula
2. Survey finds many surgeons suffer injuries from minimally invasive techniques
3. Promising new neuroimaging techniques for early detection of Alzheimers disease
4. Sanford Heart Hospital Physicians Again Recognized Internationally for Innovative Techniques
5. Hair Cloning Not Yet Recommended by Researchers Who Developed the Technique
6. New Study: Innovative Technique Allows Male Cancer Survivors Who are Sterile from Treatment to Father Children
7. New measurement technique will help in fight against cancer
8. Shoulder Repair Technique Borrows From Cadavers
9. Researchers Use New Techniques to Assess PTSD
10. Controversial kidney transplant technique could provide lifeline for very ill patients
11. The New Liposuction Technique Means No Surgery or Suction
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... (PRWEB) July 11, 2014 Utilizing the ... own, Dr. William Koenig, has topped a record number ... he has performed over 400 successful procedures without the ... Koenig is well known across the country for his ... safety record has long been the foundation for numerous ...
(Date:7/11/2014)... 2014 (HealthDay News) -- Children who have emergency ... complications and potentially even death than those who ... However, the Johns Hopkins researchers noted that ... researchers analyzed data on nearly 440,000 simple emergency ... over a 22-year period. The surgeries are ...
(Date:7/11/2014)... The report “Probiotics Market by Products (Functional Foods, ... Therapeutic, Preventive Health Care) & Ingredients (Lactobacilli, Bifidobacteria, ... ” defines and segments the global probiotics market ... value of probiotic products and ingredients. The report ... the global market with an analysis of trends, ...
(Date:7/11/2014)... 2014 Global enterprises today are shifting ... day-to-day management activities. Managed services offer these global enterprises ... economic slowdown resulted into rising operational costs to companies. ... considered to be the global market driver for expanding ... global managed services market is estimated to grow from ...
(Date:7/11/2014)... Toledo, Ohio (PRWEB) July 11, 2014 ... (Morgenson 7/10/14) and FiercePharma (Weintraub 7/11/14), a significant number ... in blood sugar, abdominal issues and even death from ... exposed. , According to the Times report , ... events in 2013 reported by patients was almost 14% ...
Breaking Medicine News(10 mins):Health News:Rochester Surgeon Hits Milestone with Keller Funnel 2Health News:Emergency Surgeries on Weekends Riskier for Kids: Study 2Health News:Probiotic Ingredient Market worth $1,732.8 Million by 2019 - A Report by MarketsandMarkets 2Health News:Probiotic Ingredient Market worth $1,732.8 Million by 2019 - A Report by MarketsandMarkets 3Health News:Probiotic Ingredient Market worth $1,732.8 Million by 2019 - A Report by MarketsandMarkets 4Health News:Probiotic Ingredient Market worth $1,732.8 Million by 2019 - A Report by MarketsandMarkets 5Health News:North America Managed Services Market Worth $68.65 Billion by 2018 - New Report by MicroMarket Monitor 2Health News:North America Managed Services Market Worth $68.65 Billion by 2018 - New Report by MicroMarket Monitor 3Health News:North America Managed Services Market Worth $68.65 Billion by 2018 - New Report by MicroMarket Monitor 4Health News:Acthar’s Deadly Adverse Events Revealed 2Health News:Acthar’s Deadly Adverse Events Revealed 3
... like pushing an elevator button or reaching for a cup ... or right hand will do the job. But the left ... of the brain receives magnetic stimulation, according to new research ... applied transcranial magnetic stimulation (TMS) to the posterior parietal cortex ...
... spiritually and medicine, will be the featured speaker at the ... Annual R.J. DeBottis Memorial Lecture on Aging on Monday, Nov. ... honored to host Dr. Koenig who is a pioneer in ... all ages," said Ira Colby, dean of the UH GCSW. ...
... HealthDay Reporter , MONDAY, Sept. 27 (HealthDay ... children exposed to tobacco ads at all, and wants ... for erectile dysfunction drugs and other prescription medications. ... in its new policy statement, "Children, Adolescents, Substance Abuse, ...
... Therapeutics, Inc. is presenting new data in five posters ... with the company,s radioprotectant Ex-RAD at the 56th Annual ... in Maui, Hawaii. In vivo studies show that ... survival versus placebo-treated groups in mice exposed to lethal ...
... healthy lifestyle habits such as eating fruits and vegetables ... their health because they tend to consume large amounts ... research at The Michael & Susan Dell Center for ... Center at Houston (UTHealth). "Children and parents ...
... appropriate training and support they need to help people who ... levels of care. Those are the key findings of ... the University of Nottingham, UK, and published in the October ... Nursing. Staff nurse Jo McHale and lecturer Anne ...
Cached Medicine News:Health News:Right or left? Brain stimulation can change which hand you favor 2Health News:Dr. Harold G. Koenig to speak at R.J. DeBottis Lecture on Aging, Nov. 8 2Health News:Pediatricians Want to Restrict Ads for Tobacco, Booze, Viagra 2Health News:Pediatricians Want to Restrict Ads for Tobacco, Booze, Viagra 3Health News:Onconova Therapeutics presents new data demonstrating radioprotection by Ex-RAD at RRS annual meeting 2Health News:Onconova Therapeutics presents new data demonstrating radioprotection by Ex-RAD at RRS annual meeting 3Health News:Sugary sports drinks mistakenly associated with being healthy, say UTHealth researchers 2Health News:Medical profession needs special training to handle self-harm, says international review 2Health News:Medical profession needs special training to handle self-harm, says international review 3
(Date:7/11/2014)... July 11, 2014 According ... by Composition of Material, Application (Healthcare, Homeland security, ... Product (Personal Instrument, Hand-Held Instruments, Fixed, and Installed ... to 2013 - 2020", published by MarketsandMarkets, the Scintillator Market ... 5.62% from 2014 to 2020, and reach $479.16 ...
(Date:7/11/2014)... , July 11, 2014 ... Market Research "Endoscopy Devices Market (Endoscopes, Endoscopic Operative Devices, ... Growth, Trends and Forecast, 2013-2019" the global endoscopy devices ... and is expected to grow at a CAGR of ... value of USD 36.9 billion in 2019. ...
(Date:7/10/2014)... 2014  Major advances in radiation therapy and ... highlighted in a three-day Oncology Summit taking place ... 2014.  Renowned national and international cancer experts from seven ... exchange knowledge on modern technologies making treatment for ... The Summit will address a wide ...
Breaking Medicine Technology:Scintillator Market will be worth $479.16 Million by 2020 2Scintillator Market will be worth $479.16 Million by 2020 3Scintillator Market will be worth $479.16 Million by 2020 4Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 2Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 3Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 4Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 5Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 6Improving quality and access to advanced cancer care in India and South Asia 2Improving quality and access to advanced cancer care in India and South Asia 3Improving quality and access to advanced cancer care in India and South Asia 4Improving quality and access to advanced cancer care in India and South Asia 5
... May 22, 2012 Prosolia, Inc. and AB SCIEX announced ... technologies developed by Dr. Gary Van Berkel and his colleagues ... an innovator in the field of mass spectrometry and is ... field.  The agreement provides Prosolia a license to a portfolio ...
... May 21, 2012  BD (Becton, Dickinson and Company) (NYSE: ... company, and Heart to Heart International, a humanitarian medical ... joint volunteer initiative to strengthen healthcare in Haiti.  A ... will build upon the progress made by their colleagues ...
Cached Medicine Technology:Prosolia and AB SCIEX reach licensing agreement 2BD and Heart to Heart International Collaborate on Second Volunteer Service Trip to Help Improve Healthcare in Haiti 2BD and Heart to Heart International Collaborate on Second Volunteer Service Trip to Help Improve Healthcare in Haiti 3
... TOX/See™ is a 1-step, hand-held, point-of-care device ... metabolites in human urine. The TOX/See device ... commonly abused drugs in 3 to 8 minutes ... Each TOX/See cassette is individually packaged to maximize ...
... The Carpal Solution offers relief from CTS ... is different from other over-the-counter CTS treatments. ... Worn during sleep, the Carpal Solution gently ... Carpal Tunnel and eliminates hand pain, numbness ...
... Linearity is a whole blood formulation ... range of the most popular glucose ... of using a control matrix that ... is packaged in ready-to-use dropper vials ...
... ESR-10 Manual Rack is a manual ... the erythrocyte sedimentation rate (ESR) of ... 1.2ml Streck ESR-Vacuum Tubes. The rack ... simultaneously. The ESR-10 Manual Rack exhibits ...
Medicine Products: