Navigation Links
New technique may help detect potential breast cancer spread
Date:5/8/2009

A new phase III clinical trial of early stage breast cancer patients has shown that a molecule designed to home in on nearby lymph nodes is just as accurate as current techniques, but faster, more specific and easier to use.

"These results will really enable molecular biology to enter the operating room for lymph node detection," said breast surgeon Anne Wallace, MD, professor of clinical surgery at the UC San Diego School of Medicine and the Moores UCSD Cancer Center, and one of the study leaders. Wallace described her team's results May 7, 2009 at the 3rd International Symposium on Cancer Metastasis and the Lymphovascular System in San Francisco.

When a woman has breast cancer, doctors want to be sure that the disease has not spread to her lymph nodes, the first place a cancer may go. The lymphatic system is a network of vessels, ducts and glands that usually carry disease-fighting cells throughout the body, but also can act as a conduit for cancer cells to access the bloodstream.

According to Wallace, the presence or absence of cancer in lymph nodes is an important predictor of breast cancer prognosis, and as a result, the appropriate treatment. But finding the right lymph nodes to test and a standardized method of doing so hasn't been easy.

Wallace and David Vera, PhD, professor of radiology at the UC San Diego School of Medicine, were instrumental in the early development and testing of the molecule, called Lymphoseek, a radiopharmaceutical that binds to the receptor on lymph node white blood cells called macrophages. The radioactive portion of the molecule essentially lights up, enabling detection of such nearby "sentinel nodes" that are the most likely candidates to biopsy for possible cancer.

The trial, led by research teams at the Moores UCSD Cancer Center, the Moffit Cancer Center in Tampa, FL and other centers, along with the Dublin, OH-based Neoprobe Corporation, which developed Lymphoseek, compared the molecule's ability to detect nearby sentinel lymph nodes to that of the standard method using blue dye and a radioactive tracer substance.

In the trial, the Moores Cancer Center team, which also examined the technique separately in melanoma patients, looked at 46 early stage breast cancer patients. Each patient received Lymphoseek, and a short time later, blue dye which can also be detected and imaged as it enters the lymph nodes.

The surgeons removed the detected lymph nodes, which were subsequently sent to pathologists to determine whether cancer was present. The researchers found that more than 98 percent of sentinel lymph nodes containing blue dye also had Lymphoseek. Twenty-eight percent of the lymph nodes were positive for cancer, 100 percent of which were detected by Lymphoseek.

"The advantage in Lymphoseek is that we now have an agent that is tested and designed specifically for detection of sentinel lymph nodes," Wallace said, noting that blue dye is not specific for this use, lasts a shorter time in the body and may not always go to only sentinel nodes. "Lymphoseek is easier to use, takes less time to find lymph nodes and is cleared faster from the body. This could standardize the process of lymph node mapping and make the process easier, particularly for less experienced surgeons."

According to Wallace, these results could lead to other research on receptor binding imaging for different types of cancers, and propel the field of imaging cancer based on molecular profiling.


'/>"/>

Contact: Steve Benowitz
sbenowitz@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Related medicine news :

1. CorMatrix Cardiovascular to Present on its ECM Technology(TM) at the Annual Advanced Cardiac Techniques in Surgery (ACTS) Symposium in New York, N.Y.
2. Medical Nurse Training, Inc. Announces New Techniques to Achieve Tremendous Savings of Lives and Medical Costs of Over $200 Billion Annually
3. MRI: Imaging technique of choice to exam pregnant patients with possible appendicitis
4. New MR technique may help save women from unnecessary breast biopsies
5. New womens imaging technique allows for a more accurate diagnosis of breast cancer
6. IAEA conference to focus on new techniques in cancer treatment
7. New technique that scrambles light may lead to sharper images, wider views
8. First noninvasive technique to accurately predict mutations in human brain tumors
9. Robot improves suture proficiency more rapidly for surgeons inexperienced in laparoscopic techniques
10. Western Orthopaedics in Denver Blends Innovative Techniques to Provide a Spectrum of Shoulder Care
11. New technique invented to reveal pancreatic stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/9/2016)... ... December 09, 2016 , ... Flottman ... and outserts. As a means of expanding capabilities Flottman has added a ... to individually code professional inserts (PIs) and patient package inserts (PPIs) that will ...
(Date:12/9/2016)... ... December 09, 2016 , ... Mediaplanet today announces distribution of ... while encouraging readers to sign up as an organ donor for the 123,000 people ... , An organ donor can save up to 8 saves through organ donation and ...
(Date:12/8/2016)... ... December 08, 2016 , ... The West ... January 1, 2017. The name change aligns the entire company with its ... health care quality. , “We are very proud of the achievements associated with ...
(Date:12/8/2016)... JENNERSVILLE, Pa. (PRWEB) , ... December 08, 2016 ... ... Penn Medicine Southern Chester County, a Property owned by an affiliate of Seavest, ... 72,000 square foot Penn Medicine Southern Chester County ambulatory care center (ACC) was ...
(Date:12/8/2016)... ... December 08, 2016 , ... Premier Fitness Camp (PFC) ... , the ultimate weight loss and wellness program, at their world headquarters of Omni ... provide immediate and long-term results to anyone seeking weight loss, personal development, a healthy ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... NEW YORK , Dec. 8, 2016 ... ... such as reducing loss of blood during surgeries, lowering the ... surgeries, and decreasing risks of SSIs. The patient warming systems ... and intravascular warming systems.These benefits in turn reduce the stay ...
(Date:12/8/2016)... -- KEY FINDINGS North America ... in 2016 and is expected to continue in the ... large number of surgical procedures that are taking place ... the patient temperature management market.) Patient warming and cooling ... blood during surgeries, lowering the risks of neurological disorders ...
(Date:12/8/2016)... Research and Markets has announced the addition of the "Endodontic Supplies - ... ... worldwide markets for Endodontic Supplies in US$ Thousand. The report provides separate comprehensive ... , Europe , Asia-Pacific , ... forecasts are provided for the period 2015 through 2022. Also, a six-year historic ...
Breaking Medicine Technology: