Navigation Links
New technique detects specific chromosomal damage, may indicate lung cancer risk
Date:8/31/2007

A new technique could pave the way toward screening people at risk for lung cancer for the genetic changes that may foreshadow malignancies, researchers from the University of Colorado say.

The most successful way to reduce mortality in cancer is prevention, said researcher Wilbur A. Franklin, M.D., Professor of Pathology at the University of Colorado Health Sciences Center. Our goal would be to develop screening techniques for lung lesions that could enable us to identify precancerous changes.

The study appears in the September 1, 2007 issue of the American Journal of Respiratory and Critical Care Medicine, published by the American Thoracic Society.

Lung cancer is the leading cause of cancer deaths in the U.S., and kills more people than the next three most common cancerscolon, breast and prostatecombined. While it is well-established that smoking is the primary risk factor for lung cancer, a number of lung cancer patients have never smoked. Additionally, quitting smoking only gradually reduces the risk of lung cancer because much of the genetic damage done by tobacco is irreversible.

Recent research suggests that the genetic changes that accompany lung cancer are not random, but are associated with specific chromosomal instabilities that may be indicative of future carcinomas. Researcher Marileila Varella-Garcia, M.D., also of UCHSC, targeted these non-random chromosomal changes in the study.

The investigators used a technique called spectral karyotyping (SKY) to examine the bronchial epithelium (BE) of 71 subjects14 patients with lung cancer, 43 smokers at high risk for developing lung cancer and 14 healthy non-smokersin the hope of identifying underlying genetic changes that might be hallmarks for cancer.

It is critically important that we thoroughly understand the nature and timing of the cellular and genetic effects of tobacco smoke on BE in order to identify biomarkers and devise intervention strategies that might reduce the persisting morbidity and mortality from lung cancer, said Dr. Varella-Garcia.

The researchers found a marked difference between the chromosomal abnormality index (CAI) of never-smokers and that of high-risk smokers and patients with lung cancer.

Theres a tremendous amount of chromosomal damage in smokers who dont yet have cancer, said Dr. Franklin. Chromosomal abnormalities were observed in 82 percent of high-risk smokers and in all patients with carcinoma, regardless of their self-reported tobacco exposure. Patients with cancer and high-risk smokers had nearly 23 and 15 times more chromosomal abnormalities, respectively, than never-smokers.

The most common changes among patients with cancer and high-risk smokers were gains on chromosomes 5, 7, 8 and 18.

The results from SKY were confirmed by fluorescence in situ hybridization (FISH). The FISH technique offers a less comprehensive view of genetic changes, but unlike SKY, can detect genetic changes in interphase cells, which are readily available in sputum samples.

Whereas SKY is not a practical tool to directly apply to sputum, it does identify candidate chromosomal sequences that could improve the sensitivity of a FISH probe set for sputum screening and risk assessment, wrote Dr. Franklin. Improvement in sensitivity and perhaps automated processing and analysis could move a FISH-based assay toward clinical application.

The researchers noted that their pilot study could not affirmatively determine whether the changes were predictive of eventual cancer, but their data point to an important avenue for future research. It will be necessary to study larger cohorts for a longer interval, they wrote, concluding, SKY FISH is a feasible technique for comprehensive evaluation of the chromosomal changes in nonmalignant bronchial epithelial cells of high-risk individuals.


'/>"/>

Contact: Suzy Martin
smartin@thoracic.org
212-315-8631
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. PCR emerging as a promising technique for Diagnosing Urinary Tuberculosis
2. New Laser Techniques cure degeneration of the eye
3. Micro-camera provides new breast imaging technique
4. IVF technique May Increase The Risk Of Birth Defects
5. New Technique For Benign Breast Tumors
6. New technique to diagnose heart disease
7. Novel biopsy technique for prostate cancer
8. New technique for heart enlargement
9. Laser technique assists beard problem
10. Comparing Breast surgery techniques
11. Latest technique for asthma treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... People across ... in Genome magazine’s Code Talker Award, an essay contest in which patients and their ... award to be presented at the 2016 National Society of Genetic Counselors (NSGC) Annual ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute Beauty ... Barry M. Weintraub as a prominent plastic surgeon and the network’s newest partner. ... and the most handsome men, look naturally attractive. Plastic surgery should be invisible.” ...
(Date:6/24/2016)... ... 2016 , ... Strategic Capital Partners, LLC (SCP) in concert ... capital for emerging technology companies. SCP has delivered investment events and professional ... than a million dollars of capital investment for five companies. The ...
(Date:6/24/2016)... ... June 24, 2016 , ... Venture Construction Group (VCG) sponsors ... on June 20th at the Woodmont Country Club at 1201 Rockville Pike, Rockville, Maryland, ... to helping service members that have been wounded in battle and their families. Venture ...
(Date:6/24/2016)... ... June 24, 2016 , ... Advanced Plastic ... Miss Arizona pageant as its official Medspa Sponsor. Dr. Josh Olson, a board-certified ... Arizona. , Dr. Olson says the decision to support the pageant in ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... N.J. , June 24, 2016  Collagen ... the design, development and manufacturing of collagen and ... regeneration announced today that Bill Messer ... and Marketing to further leverage the growing portfolio ... medical devices. Bill joins the Collagen ...
(Date:6/24/2016)... -- Research and Markets has announced ... Applications, Technologies, Forecasts" report to their offering. ... Smart Skin, Structural Health Monitoring, Composite Smart Structures, ... involves electronic and/or electrical components and circuits that ... such as vehicle bodies or conformally placed upon ...
(Date:6/24/2016)... 24, 2016 Research and Markets has ... Companion Diagnostic Tests" report to their offering. ... Diagnostics The World Market for Companion Diagnostics ... diagnostics. Market analysis in the report includes the following: ... Vitro Diagnostic Kits) by Region (N. America, EU, ROW), 2015-2020 ...
Breaking Medicine Technology: