Navigation Links
New technique catalogs lymphoma-linked genetic variations
Date:12/27/2012

As anyone familiar with the X-Men knows, mutants can be either very good or very bad or somewhere in between. The same appears true within cancer cells, which may harbor hundreds of mutations that set them apart from other cells in the body; the scientific challenge has been to figure out which mutations are culprits and which are innocent bystanders. Now, researchers at Johns Hopkins Medicine have devised a novel approach to sorting them out: they generated random mutations in a gene associated with lymphoma, tested the proteins produced by the genes to see how they performed, and generated a catalog of mutants with cancer-causing potential.

"Our goal was to correlate various mutations with potential to promote lymphoma," says Joel Pomerantz, Ph.D., an associate professor in the Johns Hopkins School of Medicine's Institute for Cell Engineering. For the study, to be reported in a January 2013 issue of Molecular and Cellular Biology, Pomerantz and his research team focused on the protein CARD11. CARD11 plays a key role in signaling the presence of infection, which leads infection-fighting white blood cells to grow and divide. Certain mutations can turn CARD11 permanently "on," causing out-of-control cell division that results in cancers called lymphomas, which strike about 75,000 Americans each year.

To find out which genetic mutations would increase CARD11's activity, Pomerantz and his team made copies of the CARD11 gene in a way that made random mutations likely. They then used the faulty copies to make mutant proteins, and tested the ability of those proteins to trigger the signaling reaction that is CARD11's specialty. This let the researchers figure out which mutations increased the protein's activity, and by how much information that can be compared to emerging data about CARD11 mutations found in human lymphomas. "We found that several of the overactive mutations we'd identified have already been found in patients," Pomerantz sa
'/>"/>

Contact: Shawna Williams
shawna@jhmi.edu
410-955-8236
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New MRI technique may predict progress of dementias
2. Detecting malaria early to save lives: New optical technique promises rapid and accurate diagnosis
3. New technique may help severely damaged nerves regrow and restore function
4. New Techniques May Improve Infant Heart Surgery
5. New surgical technique for removing inoperable tumors of the abdomen
6. New technique predictably generates complex, wavy shapes
7. Screening for breast cancer without X-rays: Lasers and sound merge in promising diagnostic technique
8. A marker in the lining of the lungs could be useful diagnostic technique for lung cancer screening
9. New technique could reduce number of animals needed to test chemical safety
10. Technique spots disease using immune cell DNA
11. Noninvasive imaging technique may help kids with heart transplants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2015)... 03, 2015 HealthPostures, a pioneering ... announces its appearance at the , May 5 - ... HealthPostures will exhibit at the conference include its bestselling ... stand solutions is the 6100 TaskMate Executive. Features of ... an adjustable keyboard tray, extended platform work surface and ...
(Date:5/2/2015)... 2015 Vancouver fencing company, QS Fencing, has ... advice to prospective clients related to their questions on railings ... railings around their decks and patios. While that seems like ... up once the person rolls up their sleeve to start ... railing in finding a gate that matches it. , Instead ...
(Date:5/2/2015)... May 02, 2015 It’s a pattern ... natural disaster strikes anywhere on this planet, cyber scammers ... sympathy and compassion for their own personal gain. ... Emergency Readiness Team) issued an alert titled “Nepal ... email scams citing the earthquake in Nepal. The scam ...
(Date:5/2/2015)... East Liverpool, Ohio (PRWEB) May 02, 2015 ... of East Liverpool City Hospital (ELCH) gathered to celebrate ... direction of River Valley Health Partners (RVHP), had zero ... and zero urinary catheter associated infections. ELCH was also ... , The management team at ELCH credited the ...
(Date:5/2/2015)... OR (PRWEB) May 02, 2015 ZoomCare, ... it has submitted plans to offer its new healthcare ... Exchange. The ZOOM+ Personal Health Insurance System is the ... up to enhance human performance. ZOOM+ Personal Health Insurance ... healthcare delivery system that are subject to review and ...
Breaking Medicine News(10 mins):Health News:HealthPostures to Appear at the Minnesota Safety and Health Conference 2Health News:HealthPostures to Appear at the Minnesota Safety and Health Conference 3Health News:Professional Staff at QS Fencing Company Now Provides Advice on Railings and Gates 2Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 2Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 3Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 4Health News:East Liverpool City Hospital Celebrates Patient Care Improvements 2Health News:ZoomCare Applies to be on Oregon Exchange 2
... to be presented today at the Society for Maternal-Fetal Medicine,s ... researchers will present findings that show that many women are ... their routine third trimester screening and a rapid test performed ... a leading cause of neonatal infection. GBS is a bacterium ...
... and older, includes nearly 3.8 million divorced men and ... end-of-life issues can be particularly difficult for singles without ... University of Missouri provides insight into the experiences of ... assistance with daily tasks and management of health needs. ...
... -- More than one-quarter of women with apparent early-stage ... check for cancer spread, which nearly doubles these patients, ... at the University of California Davis Cancer Center and ... registry data of 721 presumed early-stage ovarian cancer patients ...
... HealthDay Reporter , THURSDAY, Feb. 10 (HealthDay News) -- In ... researchers found that taking folate during pregnancy didn,t appear ... data do not support a protective effect of folate on ... have an adverse effect on pregnancy either," said study author ...
... Bayston in the School of Clinical Sciences, PhD student and ... professional training fellowship of almost 160,000 from Arthritis Research UK ... with broken bones. Pins used to mend broken ... cent of patients being treated in this way develop infections, ...
... than two thousand physicians, some of the top ... medicine, especially high risk pregnancies, gathered today for ... four days of intensive research presentations. Presentations ... (SMFM) annual meeting, The Pregnancy Meeting , represent ...
Cached Medicine News:Health News:Third trimester group B streptococcus test doesn't accurately predict presence during labor 2Health News:Study examines phenomenon of women caring for ex-husbands 2Health News:Folate May Not Protect Against Premature Birth 2Health News:Folate May Not Protect Against Premature Birth 3Health News:Anti-bacterial collar to help mend broken bones 2Health News:SMFM highlights significance of spina bifida research findings 2
(Date:5/1/2015)... Calif. , May 1, 2015  Legendary actor ... Inc. in a new PBAFacts campaign designed to educate ... to learn more about Pseudobulbar Affect (PBA) and to ... idea that an actor has the ability to cry ... the lack of control experienced by people living with ...
(Date:5/1/2015)... PORTLAND, Ore. , May 1, 2015 ... medical risk assessment company that develops, manufactures and markets ... evaluating chronic diseases, today reported financial results for the ... "In the first quarter of 2015, Semler reported continued ... sequential quarter over quarter revenue growth of 14%," said ...
(Date:5/1/2015)... -- Cambrex Corporation (NYSE: CBM ) reports results for ... Highlights , Sales increased 18% compared to the ... impact, driven by Innovator products and Controlled Substances. , ... first quarter of 2014. , GAAP Diluted EPS from ... last year and Adjusted Diluted EPS was $0.29 compared to ...
Breaking Medicine Technology:Danny Glover Joins PBA Facts Campaign, to Educate and Build Awareness of Pseudobulbar Affect (PBA), a Little Known but Widespread Neurologic Condition 2Danny Glover Joins PBA Facts Campaign, to Educate and Build Awareness of Pseudobulbar Affect (PBA), a Little Known but Widespread Neurologic Condition 3Semler Reports First Quarter 2015 Financial Results 2Semler Reports First Quarter 2015 Financial Results 3Semler Reports First Quarter 2015 Financial Results 4Semler Reports First Quarter 2015 Financial Results 5Cambrex Reports First Quarter 2015 Financial Results 2Cambrex Reports First Quarter 2015 Financial Results 3Cambrex Reports First Quarter 2015 Financial Results 4Cambrex Reports First Quarter 2015 Financial Results 5Cambrex Reports First Quarter 2015 Financial Results 6Cambrex Reports First Quarter 2015 Financial Results 7Cambrex Reports First Quarter 2015 Financial Results 8Cambrex Reports First Quarter 2015 Financial Results 9Cambrex Reports First Quarter 2015 Financial Results 10Cambrex Reports First Quarter 2015 Financial Results 11
Desmarres Retractor Size 4...
Desmarrres Lid Retractor, round serrated handle, polished finish, overall length 130 mm....
Size 4 - 2.25 mm...
Highly versatile, efficient, compact and accurate digital readout display....
Medicine Products: