Navigation Links
New technique can help nanoparticles deliver drug treatments

DETROIT A Wayne State University researcher has successfully tested a technique that can lead to more effective use of nanoparticles as a drug delivery system.

Joshua Reineke, Ph.D., assistant professor of pharmaceutical sciences in the Eugene Applebaum College of Pharmacy and Health Sciences, examined how a biodegradable polymer particle called polylactic-co-glycolic acid (PLGA) breaks down in live tissue.

He believes the potential impact of his work is broad, as nanoparticles increasingly have been developed as carriers of drug treatments for numerous diseases and as imaging agents; they also are used in numerous consumer products. The kinetics of nanoparticle biodegradation is an important factor that can control how and where a drug is released, impacting treatment efficacy as well as potential toxicity to nontarget tissues from nanoparticle exposure.

"If nanoparticles given to a patient release a drug before particles can ever get to target tissue, then we get high toxicity and low effect," Reineke said. "Conversely, if particles are drawn to a tissue but don't release the drug until long afterward, then we also don't get the therapeutic effect."

Much previous research has studied nanoparticle biodegradation in vitro, but Reineke and the study's lead author, Abdul Khader Mohammad, Ph.D., a recent WSU graduate, believe they are the first to quantify biodegradation rates after systemic administration.

Their study, "Quantitative Detection of PLGA Nanoparticle Degradation in Tissues following Intravenous Administration," was published recently in the journal Molecular Pharmaceutics. It was supported by funds from the Department of Pharmaceutical Sciences and the Office for the Vice President of Research at Wayne State.

Keeping concentration levels the same, Reineke and Mohammad administered PLGA as particles in sizes of 200 and 500 nanometers (nm) intravenously in mice, an important administration route of nanomedicines for cancer applications, for example, and measured the quantity of the nanoparticles in all tissues and the rates at which it degraded. They then compared those rates to those predicted by in vitro measurements.

Reineke said the 200 nm particles degraded much faster in the body than in vitro, while the 500 nm particles degraded similarly to in vitro analyses. The liver and spleen had the highest concentration of polymers and therefore were easiest to analyze.

Researchers found that 500 nm particles degraded faster in the liver than the spleen, but for the 200 nm size the degradation rate in the liver and the spleen were similar.

"It's known that larger particles degrade differently, and we verified that," Reineke said, "but they didn't quite degrade in vivo the way we would expect. We found that among tissue types there are differences in how they degrade."

"That tells us that in vitro degradation doesn't predict in vivo degradation very well, because we see so many differences."

Reineke said that by in vivo testing of other types of nanoparticles, a mathematical model can be developed to help determine which are most effective and have the lowest toxicity for a given application.

"Optimizing a therapeutic system that utilizes nanoparticles is really about getting that timing correct. In order to do that, we have to know how and when the particles are going to release the drug."


Contact: Julie O'Connor
Wayne State University - Office of the Vice President for Research

Related medicine news :

1. New MRI technique may predict progress of dementias
2. Detecting malaria early to save lives: New optical technique promises rapid and accurate diagnosis
3. New technique may help severely damaged nerves regrow and restore function
4. New Techniques May Improve Infant Heart Surgery
5. New surgical technique for removing inoperable tumors of the abdomen
6. New technique predictably generates complex, wavy shapes
7. Screening for breast cancer without X-rays: Lasers and sound merge in promising diagnostic technique
8. A marker in the lining of the lungs could be useful diagnostic technique for lung cancer screening
9. New technique could reduce number of animals needed to test chemical safety
10. Technique spots disease using immune cell DNA
11. Noninvasive imaging technique may help kids with heart transplants
Post Your Comments:
(Date:6/27/2016)... ... June 27, 2016 , ... A revolution is ... emergency ambulance transport experience for the millions of people who require these medical ... the taxi industry through the use of technology. Now, SmartEMS has put forth ...
(Date:6/26/2016)... North Carolina (PRWEB) , ... June 26, 2016 , ... ... release of a new product that was developed to enhance the health of felines. ... for centuries. , The two main herbs in the PawPaws Cat Kidney Support ...
(Date:6/25/2016)... ... ... closing of Bruton Memorial Library on June 21 due to a possible lice infestation, as ... of head lice: the parasite’s ability to live away from a human host, and to ... one in the event that lice have simply gotten out of control. , As lice ...
(Date:6/25/2016)... ... 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary of the ... to iHire in recognition of their exemplary accomplishments in worksite health promotion. , The ... Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. Her son ... lash out at his family verbally and physically. , “When something upset him, he couldn’t ... would use it. He would throw rocks at my other children and say he was ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... "Dialysis Devices Global Market - Forecast to 2022" report ... is the treatment method for the patients with kidney failure, ... and excess fluid from the patient,s blood and thus the ... sodium, potassium and chloride in balance. Increasing ...
(Date:6/23/2016)... , June 23, 2016 Research and ... Devices Medical Market Analysis 2016 - Forecast to 2022" ... The report contains up to date financial data derived ... Assessment of major trends with potential impact on the market ... of market segmentation which comprises of sub markets, regional and ...
(Date:6/23/2016)... and INDIANAPOLIS , June 23, 2016 ... Lilly Diabetes Tomorrow,s Leaders Scholarship is any indication, the ... announced today online at by the ... diabetes stand in the way of academic and community ... Foundation,s scholarship program since 2012, and continues to advocate ...
Breaking Medicine Technology: