Navigation Links
New targeted therapy effective in treating advanced prostate cancer
Date:4/14/2010

receptor signaling drives CRPC and that a substantial number of CRPC tumors that progress despite multiple hormone and chemotherapy treatments remain dependent on androgen receptor signaling for growth," said study co-author, Charles Sawyers, MD, Chair of Memorial Sloan-Kettering's Human Oncology and Pathogenesis Program and a Howard Hughes Medical Institute investigator.

The drug was co-invented by Dr. Sawyers and Michael Jung, PhD, Professor of Chemistry at the University of California, Los Angeles. Their research originally demonstrated that CRPC cells have increased expression of the androgen receptor and that elevated expression of this receptor may contribute to disease progression due to a developed resistance to hormone treatment. Their collaboration led to the discovery of a number of nonsteroidal, small molecule antiandrogen compounds, including MDV3100.

In the current study, 140 patients were treated with doses of MDV3100 ranging from 30 to 600 mg daily. PET imaging, bones scans, and blood tests were used to assess the antitumor effects of the drug, which were observed at all dosages. Investigators reported declines in PSA of at least 50 percent in more than half of the patients and tumor regressions in 22 percent of the patients. Overall, two-thirds of patients had partial remissions or stable disease in tumors that had spread to soft tissue or bone.

The findings also showed that the number of circulating tumor cells fell in 49 percent of patients, and 91 percent of patients who initiated therapy with favorable counts retained favorable counts during treatment. This is important because previous research shows that changes in circulating tumor cell counts after treatment were more predictive of survival than were changes in PSA, with favorable post-treatment counts associated with a 21-month median survival.

The drug was generally well tolerated, with nausea, constipation, diarrhea, and anorexia being the most common mild side effe
'/>"/>

Contact: Jeanne DAgostino
dagostij@mskcc.org
212-639-3573
Memorial Sloan-Kettering Cancer Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Kaiser Permanente Southern California to Offer FitOrbit Online Personal Training to Targeted Patients
2. Targeted agent blocked growth of deadly brain cancer in preclinical studies
3. Survival in metastatic breast cancer patients is improving: targeted therapies have contributed
4. Gene-Targeted Cancer Fix Could Be a Breakthrough
5. Targeted delivery of losartan reduces liver inflammation and scarring
6. Targeted prevention stopped spread of H1N1 at Alabama boys camp
7. Human Touch Introduces New CirQlation™ Elite Foot & Calf Massager Providing Ultimate Targeted Relief for Tired Feet and Calves
8. Middle Schoolers Identify Violent Content in Youth-Targeted Entertainment as a Strong Influence in Causing Youth Violence
9. Targeted therapy prolongs life in patients with HER2-positive breast cancer
10. Targeted Breast Ultrasound Can Reduce Biopsies for Women Under Forty
11. Targeted breast ultrasound can reduce biopsies for women under 40
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... time an oncogenic somatic mutation at amino acid 918 ... identified in small cell lung cancer (SCLC) tumors and ... produced increased intracellular signaling and cell growth. , SCLC ... 15% of all lung cancers and is strongly associated ... has been extensively examined for genomic alterations and targeted ...
(Date:8/22/2014)... Vegas, NV (PRWEB) August 22, 2014 ... by Dr. Sen and Dr. Samantha Pearson to help ... contacts, and avoid corrective vision surgery by instead improving ... Michaels, prompting an investigative review. , “There’s a ... of dollars in revenue each year—it’s because people just ...
(Date:8/22/2014)... du Sac, Wisconsin (PRWEB) August 22, 2014 ... PFTape™ System for Plantar Fasciitis, an exciting new product ... product allows you to stay active while you heal. ... application. This is truly a new technology – it ... and affordable. , FasciaDerm® PFTape™ System for Plantar ...
(Date:8/22/2014)... Back-to-school time provides an opportunity for parents to develop ... an expert suggests. "Forget New Year,s resolutions; the ... the start of a new fitness and exercise program ... the University of the Sciences in Philadelphia, said in ... likely to build up, "it,s important for mom and ...
(Date:8/22/2014)... Renal artery stenting to open blockages in ... historically been excluded from modern clinical trials, according ... in Catheterization and Cardiovascular Interventions today ... (SCAI). , University Hospitals Case Medical Center,s Sahil ... Professor of Medicine, Case Western Reserve University School ...
Breaking Medicine News(10 mins):Health News:Novel oncogenic RET mutation found in small cell lung cancer 2Health News:Restore My Vision Today: Review Exposes Natural Eye Restoration Guide by Dr. Sen and Dr. Samantha Pearson 2Health News:Mueller Introduces FasciaDerm® PFTape™ System for Plantar Fasciitis 2Health News:With Kids in School, Parents Can Work Out 2Health News:UH Case Medical Center's Dr. Parikh authors SCAI paper on renal artery stenosis treatment 2Health News:UH Case Medical Center's Dr. Parikh authors SCAI paper on renal artery stenosis treatment 3
... , Third Largest Full-Service Lab in US Realizes ROI ... TREVOSE, Pa., June 16 AirClic, a leading mobile ... Laboratories, Inc. (BRLI) the third largest full-service lab in ... AirClic technology within seven months of its deployment. , ...
... Thousands Expected for Healthy Lifestyle Celebration , , Governor Pat ... Vida! Get Up! Get Moving Day! in Chicago and State of ... 60 health and community services agencies will join the Chicago Hispanic ... Get Up! Get Moving! (TM) celebration. The ...
... birth rate , , TUESDAY, June 16 (HealthDay News) -- ... as white women, and a greater likelihood of depression may ... Researchers looked at birth-rate data collected over six years from ... included health information from about 5,000 young adults living in ...
... /PRNewswire-FirstCall/ - Nuvo Research Inc. (TSX: NRI) a Canadian ... of drug products delivered to and through the skin ... announced that it has entered into a license and ... (NYSE: COV ), a leading global provider of ...
... Receptor Mutation Test May Be Key To Identifying Patient ... Calif., June 16 Clarient, Inc. (Nasdaq: ... services resource for pathologists, oncologists, and the pharmaceutical industry, ... test that can help physicians select the proper therapy ...
... ... online. A new poll of over 4,800 health consumers from eHealthForum.com reveals ... prefer to rely on patient-only or patient-doctor opinion 63% of the time. ... in order to provide effective, timely and potentially life-saving services. , ...
Cached Medicine News:Health News:AirClic Mobile Business Solutions 'Clic' for Bio-Reference Laboratories, Inc. 2Health News:Chicago Hispanic Health Coalition Presents Third-Annual Vive tu Vida! Get Up! Get Moving!(TM) Event 2Health News:Depression May Lead to More Preemies Among Blacks 2Health News:Nuvo Research and Covidien sign U.S. license and development agreement for Pennsaid(R) and Pennsaid Plus(R) 2Health News:Nuvo Research and Covidien sign U.S. license and development agreement for Pennsaid(R) and Pennsaid Plus(R) 3Health News:Clarient Launches New Gene Mutation Test to Help Select Therapy for Non-Small Cell Lung Cancer 2Health News:Clarient Launches New Gene Mutation Test to Help Select Therapy for Non-Small Cell Lung Cancer 3Health News:Clarient Launches New Gene Mutation Test to Help Select Therapy for Non-Small Cell Lung Cancer 4Health News:Free Ask a Doctor Online Services Can Save Lives with Both Expert and Novice Input 2Health News:Free Ask a Doctor Online Services Can Save Lives with Both Expert and Novice Input 3
(Date:8/21/2014)... 2014  Vermillion, Inc. (NASDAQ: VRML ), ... women,s health, has appointed Holly B. Bauzon ... Ms. Bauzon has a proven track record in ... laboratory services companies. She has more than 20 years ... she held the position of Director, Lab Services Sales ...
(Date:8/21/2014)... ANGELES , Aug. 21, 2014 The spinal ... of the human body. Signals carried to and from the ... motor skills and nervous system. Injury or ailment here can ... or with a loss of control over their body. Though ... on a person,s life, there are more options available to ...
(Date:8/21/2014)... The Canadian Epilepsy Alliance (CEA) is thrilled to announce the ... about the most common neurological disorder in Canada ... series tells a fictional story based on the experiences of ... epilepsy. "Despite the fact that epilepsy affects ... and lack of awareness out there," says Gail Dempsey ...
Breaking Medicine Technology:Vermillion Appoints Holly B. Bauzon as VP of Sales and Managed Markets 2Don't Live in Pain: Four Life Improving Benefits of Back Surgery 2Action Heroes Harness Powers to Educate Children About Epilepsy 2Action Heroes Harness Powers to Educate Children About Epilepsy 3
... Leader with Strong Clinical Research Relationships and Proven, ... to Lead Commercialization, SANTA CLARA, Calif., Aug. ... cardiac diagnostic and services company, today,announced that Vincent ... Mr.,Renz will oversee the Company,s commercialization effort, to ...
... 15 Globus Medical, Inc., the largest,privately held ... the first FLEXUS(TM) Interspinous Spacers have been implanted ... Globus by Dr.,Donald Johnson II and Dr. Rhett ... a unilateral approach between two,spinous processes with minimal ...
Cached Medicine Technology:Vincent W. Renz Joins NewCardio as President 2Vincent W. Renz Joins NewCardio as President 3Vincent W. Renz Joins NewCardio as President 4First FLEXUS(TM) Interspinous Spacer Surgeries for IDE Clinical Trial 2
... II Smart ValveTM, Hakim, H-V ... intelligent choice for meeting the ... Automatic pressure response causes the ... the conditions present, eliminating the ...
Codman Hakim Programmable valve cylindrical offers the ability to optimize the opening pressure of a shunt system before and after implantation. A shunted patient's condition will often change over t...
Leadpoint Micro-Electrode Recording...
... Using advanced 3D matching algorithms developed by ... automatically merges image sets from a variety ... PET, regardless of acquisition orientation. Stealthmerge even ... the requirement to scan tissue outside the ...
Medicine Products: