Navigation Links
New targeted therapy effective in treating advanced prostate cancer
Date:4/14/2010

An experimental drug is showing promise for the treatment of men with an aggressive form of advanced prostate cancer. A new multicenter study has concluded that the targeted therapy MDV3100 is safe and effective for patients with castration-resistant prostate cancer (CRPC), known for its poor prognosis and limited treatment options. The research, led by investigators at Memorial Sloan-Kettering Cancer Center, appears early online and in an upcoming edition of The Lancet.

According to the findings of the Phase 1-2 study, MDV3100 not only shrank patients' tumors, but also reduced serum levels of the tumor marker prostate-specific antigen (PSA), stabilized disease that had spread to soft tissues and the bone, and reduced the number of circulating tumor cells in the blood.

"We were encouraged to see antitumor activity in men whose disease had spread to other parts of the body after either becoming resistant to previous hormone treatments or progressing following chemotherapy," said the study's lead author Howard Scher, MD, Chief of the Genitourinary Oncology Service at Memorial Sloan-Kettering. "These findings strengthen the drug's potential to change the outlook for a group of patients who currently have limited effective treatment options from which to choose."

According to the research, MDV3100 slows tumor growth and induces tumor cells to die in men with CRPC, or hormone-refractory disease, which depends on male hormones to grow, but is unresponsive or becomes resistant to standard therapies used to lower or block those hormones. MDV3100 works by blocking testosterone from binding to the androgen (male hormone) receptor, stopping the movement of the androgen receptor to the nucleus of prostate cancer cells, preventing the receptor from binding to DNA, and inducing cancer cell death, even when the expression of the androgen receptor is elevated.

"This study validates what our preclinical studies have suggested: that sustained androgen
'/>"/>

Contact: Jeanne DAgostino
dagostij@mskcc.org
212-639-3573
Memorial Sloan-Kettering Cancer Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Kaiser Permanente Southern California to Offer FitOrbit Online Personal Training to Targeted Patients
2. Targeted agent blocked growth of deadly brain cancer in preclinical studies
3. Survival in metastatic breast cancer patients is improving: targeted therapies have contributed
4. Gene-Targeted Cancer Fix Could Be a Breakthrough
5. Targeted delivery of losartan reduces liver inflammation and scarring
6. Targeted prevention stopped spread of H1N1 at Alabama boys camp
7. Human Touch Introduces New CirQlation™ Elite Foot & Calf Massager Providing Ultimate Targeted Relief for Tired Feet and Calves
8. Middle Schoolers Identify Violent Content in Youth-Targeted Entertainment as a Strong Influence in Causing Youth Violence
9. Targeted therapy prolongs life in patients with HER2-positive breast cancer
10. Targeted Breast Ultrasound Can Reduce Biopsies for Women Under Forty
11. Targeted breast ultrasound can reduce biopsies for women under 40
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/2/2015)... (PRWEB) May 02, 2015 Kare Visits LLC. ... support for busy caregivers. Kare Visits offers relief for ... assisted living facilities. According to the Caregiver Action ... an average of 20 hours a week caring for an ... the cost to hire a nurse, a caregiver is now ...
(Date:5/1/2015)... Texas (PRWEB) May 02, 2015 IDLife ... Texas, is proud to announce the addition of its ... Widerstrom is a life long athlete, growing up in ... passion after college by becoming a personal trainer and ... been the face of several TV shows highlighting her ...
(Date:5/1/2015)... (PRWEB) May 01, 2015 Royal River ... Freeport, Maine, reports on a new study that found ... joint swelling and improved physical function as well as ... severe osteoarthritis of the knee. , The report is ... Insights for Well Being® ,” which Royal River Natural ...
(Date:5/1/2015)... Hope For The Warriors® thanks All American ... Warriors® and military families. All American Ford presented two ... Warriors®, a national nonprofit dedicated to restoring a sense ... for our service members and our military families. , ... and matched small autograph fee from fans and presented ...
(Date:5/1/2015)... (PRWEB) May 01, 2015 Today the United ... expanding its fundraising efforts to help protect the rights of ... new program support country added since Girl Up began almost ... campaign aimed at supporting adolescent girls in the Rajasthan region ... Up has supported the advancement of adolescent girls in Guatemala, ...
Breaking Medicine News(10 mins):Health News:Chicagoan Seeks to Transform Industry by Launching an Innovative Elderly Care Solution 2Health News:IDLife LLC Announces New Partnership with Fitness Celebrity, Jen Widerstrom 2Health News:New Study Finds Nutrients Ease Arthritis Pain, Retailer Reports 2Health News:All American Ford Presents Donation to Nonprofit Hope For The Warriors 2Health News:United Nations Foundation’s Girl Up Campaign Announces New Funding Initiative to Support Adolescent Girls in India 2Health News:United Nations Foundation’s Girl Up Campaign Announces New Funding Initiative to Support Adolescent Girls in India 3
... in to help with care, researchers say , SUNDAY, April ... chronically ill older people in the United States live alone, ... how to take care of their parents and relatives, a ... to significantly help many patients with chronic illness manage their ...
... ... interactive feature, Keilhauer,s new microsite for Beam Seating makes specifying beam seating an easy ... ... Beam seating expand the original series to such an extent it can hardly be ...
... ... addictions, S.A. Lifeline Foundation has launched a brand new website that offers assistance and hope ... Lehi, UT ... of porn addiction is on a steady rise. Knowing this, Utah based S.A. ...
... ... proud to announce the unveiling of its brand new internet property, ... the American Consumer. TouchstoneSaunas.com offers premium quality Infrared Saunas designed ... from the highest quality materials to provide many years of reliable ...
... as the goal, while females hope to ,feel good, ... run marathons to feel good while men run for competition ... The research included 507 female and 399 male first-time marathoners, ... to reveal the participants, motivation for taking part in the ...
... ... Daniel R. Tishman to Speak on Panel, ‘Cost-Effective Sustainable Design and Development,’ on ... ... R. Tishman, Chairman and CEO of New York-based Tishman Construction Corporation, will participate in ...
Cached Medicine News:Health News:1 in 4 Chronically Ill Elderly Lives Alone 2Health News:Keilhauer's Expanded Beam Seating Launches With its Own Microsite 2Health News:Keilhauer's Expanded Beam Seating Launches With its Own Microsite 3Health News:S.A. Lifeline Foundation Offers New and Improved Website for Those with Pornography Addictions 2Health News:Touchstone Saunas Goes Online to Provide Premium Quality Infrared Saunas 2Health News:Are Male Marathoners More Competitive Than Women? 2Health News:Tishman Construction – World Leader in Sustainable Real Estate Development and Project Management – Exhibits at Abu Dhabi Cityscape 2Health News:Tishman Construction – World Leader in Sustainable Real Estate Development and Project Management – Exhibits at Abu Dhabi Cityscape 3Health News:Tishman Construction – World Leader in Sustainable Real Estate Development and Project Management – Exhibits at Abu Dhabi Cityscape 4Health News:Tishman Construction – World Leader in Sustainable Real Estate Development and Project Management – Exhibits at Abu Dhabi Cityscape 5
(Date:5/1/2015)... 01, 2015 /PRNewswire/ --Research and Markets ( ... Clinical Chemistry Analyzer Market by Product, by End-Users - Forecast ... American Clinical Chemistry Analyzers market is estimated to grow at ... as the U.S., Canada , ... of Americas (RoA) are covered in this report. ...
(Date:5/1/2015)... CAMBRIDGE, Mass. , May 1, 2015  Portal ... innovative drug delivery systems, announced today that Robert ... Hunter , Ph.D., University of Auckland Distinguished Professor have ... are thrilled to welcome two esteemed biotechnology leaders, Professor ... , to our team," said Dr. Patrick Anquetil ...
(Date:5/1/2015)...  CytRx Corporation (CYTR), a biopharmaceutical research and ... results for the three months ended March 31, ... and upcoming milestones for its clinical development programs. ... early months of 2015, including the announcement of ... in patients with soft tissue sarcoma, and positive ...
Breaking Medicine Technology:Americas Clinical Chemistry Analyzer (Semi-Automated Clinical Chemistry and Fully-Automated Clinical Chemistry) Market - Forecast to 2019 2Portal Instruments Adds Two Esteemed Biotechnology Leaders to its Scientific Advisory Board 2Portal Instruments Adds Two Esteemed Biotechnology Leaders to its Scientific Advisory Board 3Portal Instruments Adds Two Esteemed Biotechnology Leaders to its Scientific Advisory Board 4CytRx Reports First Quarter 2015 Financial Results 2CytRx Reports First Quarter 2015 Financial Results 3CytRx Reports First Quarter 2015 Financial Results 4CytRx Reports First Quarter 2015 Financial Results 5CytRx Reports First Quarter 2015 Financial Results 6CytRx Reports First Quarter 2015 Financial Results 7CytRx Reports First Quarter 2015 Financial Results 8CytRx Reports First Quarter 2015 Financial Results 9CytRx Reports First Quarter 2015 Financial Results 10CytRx Reports First Quarter 2015 Financial Results 11
... Niiki Pharma Inc. announced interim results from the ongoing ... NKP-1339 is a first-in-class transferrin targeted small molecule that ... and a tumor survival factor. NKP-1339 ... in patients with metastatic solid tumors resistant to standard ...
... height, their exact measurements have made seca the world,s ... company is taking a giant step forward with its ... The new seca 360 wireless system resolves ... of weight, height and other general health parameters.  This ...
Cached Medicine Technology:Niiki Pharma Announces Positive Interim Data from Ongoing Clinical Trial of Novel Anti-Cancer Agent NKP-1339 2Niiki Pharma Announces Positive Interim Data from Ongoing Clinical Trial of Novel Anti-Cancer Agent NKP-1339 3Niiki Pharma Announces Positive Interim Data from Ongoing Clinical Trial of Novel Anti-Cancer Agent NKP-1339 4seca 360 wireless - The New Era of Measuring and Weighing 2
... Sun Med TruFlow™ Oxygen flowmeter with ... lifetime warranty covering calibration and manufacturing defects. ... to meet most needs. Also available with ... auxiliary power take-off and double unit configurations. ...
... Oxygen flowmeter with a Lexan®inner calibrated flow ... and manufacturing defects. A wide range of ... Also available with all popular inlet connections, ... double unit configurations. Our extra large knob ...
The Soft-Touch Timeter® Flowmeter is durable, long-lasting and easy to maintain. Timeter ® by Allied Flowmeters: Quality Plus Value....
The Soft-Touch Timeter® Flowmeter is durable, long-lasting and easy to maintain. Timeter ® by Allied Flowmeters: Quality Plus Value....
Medicine Products: