Navigation Links
New targeted drug helps smokers stub it out
Date:3/17/2011

Researchers working in a research project within the Academy of Finland's Research Programme on Substance Use and Addictions have been developing a targeted drug that could aid in smoking reduction therapy. The new drug slows down the metabolism of nicotine, which would help smokers to cut down their smoking.

Nicotine is absorbed rapidly through the lining of the mouth but most readily through the lungs, from where it quickly passes through the body and into the brain. Once the nicotine reaches the liver, it is metabolised by an enzyme called CYP2A6. Preliminary studies by the Canadian partner of the research project have shown that inhibitors of the nicotine-metabolising CYP2A6 enzyme can help smokers curb the need to smoke. Unfortunately, current CYP2A6 inhibitors are not viable options for anti-smoking therapy, as they involve too many adverse effects.

"We're working on developing a CYP2A6 inhibitor, a targeted drug that would only be effective in specific parts of the body. Thankfully, we have a very clear picture of the structure of CYP2A6, and we'll be able to use computer-aided modelling methods to design molecules that will bind specifically to the target without disturbing other functions in the body. We've now finished our four-year project and have discovered several molecules of an until-now-unknown structure. Along the way, we've gained new insights into how the molecules bind to the active centre of the CYP2A6 enzyme. However, it'll take a good while and money before these molecules can be developed into a targeted drug," says Hannu Raunio, the principal investigator of the research project and Professor of Pharmacology at the University of Eastern Finland.

Traditional anti-smoking therapy has long been focused on smoking cessation. At present, there are a wide variety of treatments available to help smokers quit. Nicotine, buproprion and varenicline are among the most common drugs used in the treatment of smoking a
'/>"/>

Contact: Professor Hannu Raunio
hannu.raunio@uef.fi
358-405-200-202
Academy of Finland
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Ohio State study: Targeted ovarian cancer therapy not cost-effective
2. VCU Massey first to combine targeted agents to kill multiple myeloma cells
3. IU Personalized Medicine Institute to develop targeted and individualized treatments
4. Targeted particle fools brains guardian to reach tumors
5. PET scans may allow early prediction of response to targeted therapy of thyroid cancer
6. UMMS and Lundbeck to explore potential targeted therapy for Huntingtons disease
7. Study provides molecular rationale for combining targeted agents to treat breast cancer
8. Protein targeted to stop melanoma tumor growth
9. International clinical trial tests targeted drug for melanoma
10. Targeted breast ultrasound plays key role in evaluating breast abnormalities in women younger than 40
11. Targeted therapy reactivates guardian of the genome in resistant cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... 15, 2014 (HealthDay News) -- As gas prices rose ... a new study suggests. In times of gas ... those riders are inexperienced, the researchers explained. They ... which has the highest number of motorcycle registrations in ... motorcyclist deaths. The analysis revealed a strong association ...
(Date:12/17/2014)... Alan Mozes HealthDay Reporter ... holiday party season fast approaching, a new study reveals that ... arrests have fewer drunk drivers on their roads. The ... vigilantly are better able to deter inebriated revelers from getting ... new laws are being passed regarding drinking and driving," said ...
(Date:12/15/2014)... 15, 2014 Veretekk.com, Inc. announced today ... Avenue. JM Ocean Avenue has secured exclusive benefit ... automated marketing system. JM Ocean Avenue is a ... of Ocean Avenue and JM International, with partial ownership ... per year company. , “After nearly 2 decades of ...
(Date:12/15/2014)... Boston, MA (PRWEB) December 15, 2014 ... health management solutions, announced today that it has ... for Quality Assurance (NCQA) for its Disease Management ... obstructive pulmonary disease (COPD), coronary heart disease and ... accreditation from NCQA for Health Dialog’s Disease Management ...
(Date:12/15/2014)... December 15, 2014 Emergo Group, Inc., ... 26 countries in North and South America, Europe, the ... from industry participants for its 2015 Medical Device Industry ... to identify upcoming business and market trends as well ... The survey targets areas including:, , ...
Breaking Medicine News(10 mins):Health News:When Gas Prices Go Up, So Do Motorcycle Accidents, Study Finds 2Health News:Enforcement of Drunk Driving Laws Makes Roads Safer, Study Finds 2Health News:Enforcement of Drunk Driving Laws Makes Roads Safer, Study Finds 3Health News:JM Ocean Avenue secures the strategic advantages of Veretekk 2Health News:JM Ocean Avenue secures the strategic advantages of Veretekk 3Health News:JM Ocean Avenue secures the strategic advantages of Veretekk 4Health News:Health Dialog Receives NCQA Accreditation for Disease Management Programs 2Health News:Emergo’s Annual Survey Assessing the State of the Medical Device Industry Now Open 2
... Valentine Appointed to Act as President and COO of iCRco , ... ... announce the appointment of Mr. Mark Valentine as the new President and ... five years, Mr. Valentine assumes the duties of President while keeping the ...
... mild and recovery is fairly quick , , SATURDAY, May ... United States now stands at 2,254 confirmed cases and 722 ... officials said Saturday. , "We had expected more cases and ... deputy director for science and public health program at the ...
... The way people savor flavor compounds the problem, experts say ... wearing away at a faster rate than ever, dissolving under ... dental experts say. , Dental erosion -- the loss of ... increase in the United States. The condition occurs when enamel ...
... maintain their commitment to the highest level of excellence, achieving ASQ ... ... 2009 -- The Certification Board of the American Society for Quality ... Repair Consultants have completed the requirements to be named an ...
... a statement of Matthew L. Myers, President, Campaign for ... ) Hawaii leaders have taken an important step to ... toll of tobacco use by increasing the state cigarette ... July 1 -- giving the state the third highest ...
... WASHINGTON, May 8 There is a direct connection ... yesterday will greatly help to better understand and minimize ... said the American Public Health Association. The bill -- ... calls for developing a national strategic action plan for ...
Cached Medicine News:Health News:iCRco Names Mark Valentine President and COO 2Health News:Confirmed Swine Flu Cases in U.S. Near 2,300 Mark 2Health News:Confirmed Swine Flu Cases in U.S. Near 2,300 Mark 3Health News:Confirmed Swine Flu Cases in U.S. Near 2,300 Mark 4Health News:Confirmed Swine Flu Cases in U.S. Near 2,300 Mark 5Health News:Confirmed Swine Flu Cases in U.S. Near 2,300 Mark 6Health News:Confirmed Swine Flu Cases in U.S. Near 2,300 Mark 7Health News:Confirmed Swine Flu Cases in U.S. Near 2,300 Mark 8Health News:Confirmed Swine Flu Cases in U.S. Near 2,300 Mark 9Health News:Confirmed Swine Flu Cases in U.S. Near 2,300 Mark 10Health News:Acid Drinks Blamed for Increase in Tooth Erosion 2Health News:Acid Drinks Blamed for Increase in Tooth Erosion 3Health News:Clinical Instrument Repair Consultants Receive ASQ-Certified Quality Inspector 2Health News:Hawaii Cigarette Tax Increase Delivers Victory for Kids and Taxpayers 2
(Date:12/15/2014)... Research and Markets ( http://www.researchandmarkets.com/research/bf3b6l/electrocardiogram ) ... Devices - Global Trends, Estimates and Forecasts, 2012-2018" ... http://photos.prnewswire.com/prnh/20130307/600769 Global Electrocardiogram Devices (ECG) sector ... North America accounts for nearly ... Europe claims approximately 27% (2018). ...
(Date:12/15/2014)... PLYMOUTH MEETING, Pa. , Dec. 15, 2014 ... ) announced today it has been added to ... the NASDAQ Biotechnology Index will become effective upon ... The NASDAQ Biotechnology Index is designed to track ... that are classified as either biotechnology or pharmaceutical ...
(Date:12/15/2014)... MARCOS, Texas , Dec. 15, 2014  Stephen ... dot manufacturer Quantum Materials Corp (OTCQB:QTMM), will ... Center for Quantum Materials (RCQM) on December 16th, 2014. ... exploration of exotic nanomaterials in attracting top faculty and ... Rice to collaborate on research. "We ...
Breaking Medicine Technology:Electrocardiogram (ECG) Devices - Global Trends, Estimates and Forecasts, 2012-2018 2Electrocardiogram (ECG) Devices - Global Trends, Estimates and Forecasts, 2012-2018 3Electrocardiogram (ECG) Devices - Global Trends, Estimates and Forecasts, 2012-2018 4Inovio Pharmaceuticals Added to NASDAQ Biotechnology Index 2Inovio Pharmaceuticals Added to NASDAQ Biotechnology Index 3Inovio Pharmaceuticals Added to NASDAQ Biotechnology Index 4Quantum Materials CEO Stephen Squires to Speak at Rice Center for Quantum Materials Launch 2Quantum Materials CEO Stephen Squires to Speak at Rice Center for Quantum Materials Launch 3
... Aug. 18, 2011 Insource Spend Management Group, ... services, announced it has hit a milestone of ... clients.  Many Fortune 500 clients have individually saved ... of software, analytics and expert negotiation. Shippers across ...
... Chief Financial Officer of Chembio Diagnostics, Inc. (OTCQB: CEMI) (OTC.BB: ... is among the recipients of the "2011 CFO of the ... LIBN ).  A total of 27 CFOs were awarded the ... of two CFOs of a public company with revenue under ...
Cached Medicine Technology:Insource Saves Clients Over $1 Billion on Parcel Shipping 2Chembio Diagnostics' CFO Richard J. Larkin Among the Recipients of "2011 CFO of the Year" Award from Long Island Business News 2Chembio Diagnostics' CFO Richard J. Larkin Among the Recipients of "2011 CFO of the Year" Award from Long Island Business News 3
10% Casein digest (NZ amine), 5.0% Sodium Chloride, 5.0% Yeast Extract....
0.5% Yeast Extract, 2.0% Tryp, 10mM Sodium Chloride, 2.5mM Potassium Chloride....
S.O.C. Medium...
... rHead Radial Implant System provides todays ... to radial head replacement. Modular ... patient anatomy while minimizing ligamentous and ... designed alignment guide assists in both ...
Medicine Products: