Navigation Links
New target to stop cancer's spread discovered by Georgia State scientists
Date:1/30/2013

Disrupting a key interaction between two types of proteins in cells inhibits the spread of cancerous cells, providing researchers with a new pathway toward developing cancer-fighting drugs, according to new findings by Georgia State University scientists.

Cell migration is essential for the spread of cancerous cells, also known as metastasis, as well as for other diseases. The research team in the labs of Zhi-Ren Liu, professor of biology, and Jenny Yang, professor of biochemistry, studied the interaction of two molecules, p68 RNA helicase and calcium-calmodulin.

Interrupting the interaction between p68 and calcium-calmodulin, which is essential for cell migration, inhibited metastasis.

The findings were recently published in Nature Communications.

"Cancer, at its primary site, will not necessary kill," Liu explained. "Cancer kills by multi-site metastasis. If we are able to disrupt this interaction, we will able to inhibit cancer metastasis. The research indicates that the interaction is absolutely required for all cell migration, and we suspect it may not be limited to cancerous-type cells. It may be a general phenomenon for all cell types."

Calcium-calmodulin is an important protein, acting like a messenger to turn different proteins on and off, said Yang, whose lab focuses on calcium's role in biological processes.

"Calmodulin is a very interesting protein and it interacts with many different systems in response to calcium level changes," she said. "We have demonstrated a new target. There are new ways possible to modulate calcium signaling as a way to treat diseases."

Because cell migration is a common phenomenon that is not only normal, but also related to diseases, there are impacts on treating other diseases, Liu said, from inflammation to neurodegenerative diseases and heart disease.


'/>"/>

Contact: Jeremy Craig
jcraig@gsu.edu
404-413-1357
Georgia State University
Source:Eurekalert

Page: 1

Related medicine news :

1. High Complexity Laboratory Testing Supports New Targeted Therapies for Leukemias and Lymphomas
2. Treatment targeting PI3K may delay resistance to anti-HER2 therapy in breast cancer patients
3. Astrocytes identified as target for new depression therapy
4. LSUHSC research provides new drug target for Her-2 related breast cancer
5. Drug targets hard-to-reach leukemia stem cells responsible for relapses
6. Researchers identify new target for common heart condition
7. Targeting use of acid-suppressants in hospital patients
8. Ovarian cancer stem cell study puts targeted therapies within reach
9. Mayo Clinic researchers find new molecule to target in pancreatic cancer treatment
10. Targeted gene silencing drugs are more than 500 times more effective with new delivery method
11. UGA research offers new targets for stroke treatments
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... Indianapolis, Ind. (PRWEB) , ... May 03, 2016 ... ... today that it has been selected by Tidelands Health, a three hospital system ... need to be constantly on the lookout for technology that enhances communication, drives ...
(Date:5/3/2016)... ... , ... Nationally recognized personal injury law firm Monge & Associates is honoring Moms ... who wants one for their Mother or any other mother figure. , According to law ... Monge goes on to say, “we are choosing to do this by giving free ...
(Date:5/3/2016)... ... 2016 , ... Ogawa World USA introduced the first of its kind ... Smart Application. The Smart 3D combines the best in technological advancement, design, and massage ... and specialized massage program, each user has a tailored experience unparalleled by any other ...
(Date:5/3/2016)... ... May 03, 2016 , ... ... Canada’s top Information and Communication Technology (ICT) companies in the annual Branham300 listing. ... companies operating in Canada, as ranked by revenue. , “We are honored ...
(Date:5/3/2016)... ... May 03, 2016 , ... Huntington Beach orthopedic ... of surgical procedure that can be used to diagnose and treat joint problems. During ... inserted. These instruments include a special lighting system and lens that illuminate and magnify ...
Breaking Medicine News(10 mins):
(Date:5/2/2016)... 2, 2016 Kalorama Information noted the 5 ... market in a recent white paper.  The healthcare market ... usage, a growing market are among the top drivers ... report EMR 2016: The Market for Electronic ... complete study of the EMR industry, and the report ...
(Date:5/2/2016)...  Deerfield announced today it led the $44.5 ... Graybug Vision is an early stage pharmaceutical company ... for ocular diseases including wet age-related macular degeneration ... developed at Johns Hopkins University and has been ... Graybug Vision is developing ophthalmology products enabling ...
(Date:5/2/2016)... LAWRENCEVILLE, N.J. , May 2, 2016 /PRNewswire/ ... drug development company, today announced data from the ... dose escalating clinical trial (the OVATION Study) combining ... of care for the treatment of newly-diagnosed patients ... chemotherapy followed by interval debulking surgery.  In the ...
Breaking Medicine Technology: