Navigation Links
New target for heart failure therapy identified
Date:3/16/2009

(PHILADELPHIA) A novel signaling pathway plays a significant role in the production of aldosterone, a hormone that promotes heart failure after a myocardial infarction, according to a study conducted by Thomas Jefferson University researchers.

The findings, which will be published online this week in Proceedings of the National Academy of Sciences, show that aldosterone production is mediated by a protein called beta-arrestin-1. Beta-arrestin-1 binds to angiotensin II receptors when they are activated by angiotensin II.

Aldosterone is secreted by the adrenal cortex. Its levels are elevated in chronic heart failure, and its presence contributes to morbidity and mortality of the disease. It contributes to heart failure progression and diminished cardiac function after myocardial infarction.

The production of aldosterone was previously thought to be solely the result of the activation of G-proteins, which are also activated when angiotensin II binds to its receptors, according to Anastasios Lymperopoulos, Ph.D., a Post-Doctoral Research Fellow in the Center for Translational Medicine and the George Zallie and Family Laboratory for Cardiovascular Gene Therapy at Jefferson Medical College of Thomas Jefferson University.

"The bottom line is that in order to effectively suppress aldosterone production, you need to inhibit beta-arrestin-1 in addition to inhibiting G-proteins," said Dr. Lymperopoulos, who is the lead author of the study.

All the drugs currently available for suppression of aldosterone by angiotensin II primarily target G-protein signaling pathways. However, Walter Koch, Ph.D., the W.W. Smith Professor of Medicine and the Director of the Center for Translational Medicine and the George Zallie and Family Laboratory for Cardiovascular Gene Therapy, said that these data clearly show that beta-arrestin1 plays a more significant role in aldosterone secretion than G-proteins.

"Aldosterone secreti
'/>"/>

Contact: Emily Shafer
emily.shafer@jefferson.edu
215-955-5291
Thomas Jefferson University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. A new molecular zip code, and a new drug target for Huntingtons disease
2. Investigational Agent Targeting Metabotropic Glutamate 2/3 Receptors Demonstrates Antipsychotic Activity in Humans, Study in Nature Medicine Finds
3. National Council of Negro Women (NCNW) Partners With Sherwin-Williams to Target Lead Risks in Neglected Housing
4. U.S. Health Initiative Targets Aging Hispanics
5. Global Health Project targets reducing AIDS among Indias adolescents
6. Study suggests brain tumors need treatment with multiple targeted drugs
7. GP targets on heart disease should be simpler and based more on treatment and prevention
8. T vs. B: Re-engineered human T cells effectively target and kill cancerous B cells
9. Chronic infection persists by targeting stromal cell network in lymphoid organs
10. Prime Access Creates Groundbreaking Ads Targeting Urban Teens for the White Houses National Youth Anti-Drug Media Campaign
11. International Law Enforcement Operation Targets Underground Manufacture of Anabolic Steroids
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/1/2015)... ... 01, 2015 , ... The 28th annual Charity Horse Show hosted by the ... at 6 p.m. in Pugh Bourne Park, 343 Oakfield Road. The event will again ... an Elvis impersonator, a silent auction and concessions. , Horses and riders from around ...
(Date:7/1/2015)... (PRWEB) , ... July 01, 2015 , ... Convoy ... a community celebration in the Twin Cities on Saturday, August 1, at Spring Lake ... Cities community will provide more than $1 million worth of goods and services including ...
(Date:7/1/2015)... ... 01, 2015 , ... RowdMap Inc. is a proud participant ... “Pro-actively Identifying the High-Cost Patient Population: Insights from the Health Care Transformation Task ... http://www.hcttf.org/resouces-tools . , The Healthcare Transformation Task Force is a group of private ...
(Date:7/1/2015)... , ... July 01, 2015 , ... Franklin University, one ... Dr. Leslie King has been named Dean of the College of ... Dr. King will promote and support the vision and mission of Franklin University via ...
(Date:7/1/2015)... ... July 01, 2015 , ... ... summer sale. Customers purchasing two or more Bunion Booties directly from their ... , Bunion Bootie temporarily corrects misaligned toes and its ultra thin properties allow ...
Breaking Medicine News(10 mins):Health News:Convoy of Hope Hosts Community Event in the Twin Cities 2Health News:A Population Based Approach to Pay for Value: RowdMap, Inc. Contributes to Health Care Transformation Task Force White Paper 2Health News:A Population Based Approach to Pay for Value: RowdMap, Inc. Contributes to Health Care Transformation Task Force White Paper 3Health News:Franklin University Appoints Dean of College of Health & Public Administration 2Health News:Bunion Bootie, the #1 Non-Surgical Treatment for Bunion Pain, Announces Their Big Summer Sale 2
... organs in every brachytherapy procedure should be carefully analyzed ... every patient, according to a new guideline co-authored by ... department of Radiation Oncology at Thomas Jefferson University. ... by the American Association of Physicists in Medicine (AAPM), ...
... behavior, study finds, , MONDAY, Nov. 2 (HealthDay News) ... is linked to aggression in young children. , This ... Archives of Pediatrics & Adolescent Medicine , found that ... indirect viewing in the household were both associated with ...
... ... care legislation pending in Congress, Americans are anxious to see how the ... with reform and advances in medicine on the horizon, nearly 1.5 million ... 50 Million Pound Challenge, which announced this week the loss of its ...
... ... statement on prostate cancer testing, clarifying the Association,s recommendations and support of early detection. ... (Vocus) November ... disparaging prostate cancer testing. We are concerned that these reports are causing significant confusion ...
... 2 IPC The Hospitalist Company, Inc. (Nasdaq: IPCM ... financial results for the third quarter ended September 30, 2009. ... 2008): , Net revenue increased 23% to $77.5 million, ... encounters increased 19% to 823,000 Income from operations rose ...
... Nov. 2 comScore, Inc. (Nasdaq: ... and ImpactRx, a pharmaceutical insights company, today announced the ... only digital measurement solution that connects physicians, online and ... solution is carefully designed to comply with health privacy ...
Cached Medicine News:Health News:Task force develops new radiation guidelines for brachytherapy 2Health News:TV May Increase Aggression in Toddlers 2Health News:TV May Increase Aggression in Toddlers 3Health News:America Battles Obesity, Dropping 5 Million Pounds 2Health News:America Battles Obesity, Dropping 5 Million Pounds 3Health News:AUA Releases Statement Clarifying Prostate Cancer Testing Recommendations 2Health News:AUA Releases Statement Clarifying Prostate Cancer Testing Recommendations 3Health News:IPC The Hospitalist Company Reports Third Quarter 2009 Results 2Health News:IPC The Hospitalist Company Reports Third Quarter 2009 Results 3Health News:IPC The Hospitalist Company Reports Third Quarter 2009 Results 4Health News:IPC The Hospitalist Company Reports Third Quarter 2009 Results 5Health News:IPC The Hospitalist Company Reports Third Quarter 2009 Results 6Health News:IPC The Hospitalist Company Reports Third Quarter 2009 Results 7Health News:IPC The Hospitalist Company Reports Third Quarter 2009 Results 8Health News:IPC The Hospitalist Company Reports Third Quarter 2009 Results 9Health News:IPC The Hospitalist Company Reports Third Quarter 2009 Results 10Health News:IPC The Hospitalist Company Reports Third Quarter 2009 Results 11Health News:IPC The Hospitalist Company Reports Third Quarter 2009 Results 12Health News:IPC The Hospitalist Company Reports Third Quarter 2009 Results 13Health News:comScore Announces Availability of comScore/ImpactRx Physician Behavioral Measurement(TM) Solution 2Health News:comScore Announces Availability of comScore/ImpactRx Physician Behavioral Measurement(TM) Solution 3
(Date:7/1/2015)... DUBLIN , June 24, 2015 ... has announced the addition of the "2015 ... to their offering. This new 175-page ... market segments, including diabetes (strips and meters), pregnancy, ... dynamics, size, growth, regulatory requirements, technologies, and competitive ...
(Date:7/1/2015)... July 1, 2015  Unilife Corporation (NASDAQ: UNIS ... of injectable drug delivery systems, announced today that its ... June 30, 2015. This amendment removed a covenant that ... cash receipts from customers during the six months ended ... any of the terms of the debt agreement as ...
(Date:7/1/2015)... 1, 2015  MEI Pharma, Inc. (Nasdaq: MEIP ), ... therapies for cancer, announced today that Daniel P. Gold ... the inaugural Cantor Fitzgerald Healthcare Conference on Wednesday, July 8, ... Meridien in New York . A ... www.meipharma.com . A replay will be available approximately one hour ...
Breaking Medicine Technology:2015 Strategies in the Home/Self Testing Market 2Unilife and OrbiMed Amend Debt Financing Agreement 2Unilife and OrbiMed Amend Debt Financing Agreement 3MEI Pharma to Present at Cantor Fitzgerald Healthcare Conference 2
... , , DURHAM, N.C. , ... expanding contract developer and manufacturer of prescription pharmaceutical products, ... China .  This new facility will expand Gorbec,s current ... taking this action to better serve its U.S. customer ...
... , CARLSBAD, Calif. , Feb. 4 ... services, announced today that it expects to report its financial results for ... Select Market on Thursday, February 25, 2010 . , A ... Ph.D., and other members of senior management will take place on the ...
Cached Medicine Technology:Gorbec Pharmaceutical Services, Inc. Announces the Launch of Its GMP Analytical Laboratory in China 2Genoptix, Inc. to Announce Fourth Quarter and Full-Year 2009 Financial Results 2Genoptix, Inc. to Announce Fourth Quarter and Full-Year 2009 Financial Results 3
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: