Navigation Links
New target discovered for treatment of cancer
Date:1/11/2010

Researchers at the Swedish medical university Karolinska Institutet have discovered a new way of blocking the formation of blood vessels and halting the growth of tumours in mice. A substance that exploits this mechanism could be developed into a new treatment for cancer.

For a cancer tumour to be able to grow larger than the size of a pea, the cancer cells need to stimulate the formation of new blood vessels that can supply the tumour with oxygen and nutrients, a process known as angiogenesis. A number of medicines which inhibit angiogenesis have been developed, but their effect has been limited, and there is still a major need for better medicines.

The new results concern a receptor on the surface of blood vessel cells called ALK1. When the researchers blocked ALK1 in tumours in mice, angiogenesis was inhibited and the tumours stopped growing. The ALK1 receptor is activated by a family of signalling proteins called TGF-β proteins that are very important for communication between different types of cell in a wide range of key processes in the body. The study indicates that two members of the TGF-β family (TGF-β and BMP9) work together to stimulate angiogenesis in tumours.

ALK1 was blocked partly by genetic means and partly using a pharmaceutical substance called RAP-041.

"We believe that RAP-041 could be used in combination with existing angiogenesis inhibitors to achieve the maximum effect," says associate professor Kristian Pietras, who led the study.

Clinical studies of ACE-041, the human equivalent of RAP-041, have already been begun in the USA by the company that holds the patent on the substance. One goal of these studies is to find out which types of tumour are most sensitive to ALK1 blockade.


'/>"/>

Contact: Press Officer Katarina Sternudd
katarina.sternudd@ki.se
46-852-483-895
Karolinska Institutet
Source:Eurekalert

Page: 1

Related medicine news :

1. A new molecular zip code, and a new drug target for Huntingtons disease
2. Investigational Agent Targeting Metabotropic Glutamate 2/3 Receptors Demonstrates Antipsychotic Activity in Humans, Study in Nature Medicine Finds
3. National Council of Negro Women (NCNW) Partners With Sherwin-Williams to Target Lead Risks in Neglected Housing
4. U.S. Health Initiative Targets Aging Hispanics
5. Global Health Project targets reducing AIDS among Indias adolescents
6. Study suggests brain tumors need treatment with multiple targeted drugs
7. GP targets on heart disease should be simpler and based more on treatment and prevention
8. T vs. B: Re-engineered human T cells effectively target and kill cancerous B cells
9. Chronic infection persists by targeting stromal cell network in lymphoid organs
10. Prime Access Creates Groundbreaking Ads Targeting Urban Teens for the White Houses National Youth Anti-Drug Media Campaign
11. International Law Enforcement Operation Targets Underground Manufacture of Anabolic Steroids
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... September 23, 2014 Steven Winter Associates, ... firm’s recent projects in the State of Connecticut – ... Gateway at 570 – were honored by the Connecticut ... Awards held on September 18, 2014 at Stepping Stones ... High School, Bridgeport , Recipient of the Institutional Award ...
(Date:9/23/2014)... (PRWEB) September 23, 2014 ... of 3.7 out of 5, indicating moderate buyer ... portable and range from basic household carbon monoxide ... gas concentrations in parts per million. Buyers benefit ... choice of many suppliers, especially amongst distributors,” according ...
(Date:9/23/2014)... (PRWEB) September 23, 2014 Ale Gicqueau, ... presenting on Advanced Data Visualization for Clinical Trials at ... SDE in San Francisco on Friday, September 26, 2014. ... by volunteers. Since its inception, PhUSE has expanded from ... to a global platform for the discussion of topics ...
(Date:9/23/2014)... With the emergence of CVS Health and its ... retail chains are transforming the healthcare landscape to provide ... shoppers. In this capacity, Inside Pharmacy™ is a forum ... share their knowledge on patient care, achieve professional success, ... with other colleagues inside the pharmacy. , This latest ...
(Date:9/23/2014)... September 23, 2014 Published by Nationwide Lifts, ... issues to take charge of their mobility in a new ... positively impactful. Stair lifts are that equipment and ... “Being in the elevator business, I’ve seen so ... themselves or a loved one with mobility issues,” said Andy ...
Breaking Medicine News(10 mins):Health News:Steven Winter Associates’ Projects Receive 2014 Green Building Awards 2Health News:Steven Winter Associates’ Projects Receive 2014 Green Building Awards 3Health News:Gas Detectors Procurement Category Market Research Report Now Available from IBISWorld 2Health News:Gas Detectors Procurement Category Market Research Report Now Available from IBISWorld 3Health News:Clinovo Sponsors and Presents at Pharmaceutical Users Software Exchange (PhUSE) SDE in San Francisco 2Health News:Retail Pharmacies at the Forefront of Primary Care Innovation 2Health News:Nationwide Lifts, America’s Leader in Home Elevators, Is Proud to Announce the Release of Its First Book, “Stair Lifts: Move Up, Not Out!” 2
... when therapy goes to more than just severe cases, ... Pregnant women who receive treatment for the mildest forms ... self-monitoring of blood glucose levels and possibly insulin therapy ... or develop preeclampsia or high blood pressure during pregnancy, ...
... ... Kraft , ... September 30, 2009 -- The Boston biotechnology industry will get an early look at biotech,s ... 27, 2009 at Harvard Medical School. , , ,At the one-day event, recently funded companies ...
... children don,t see their family dentist until they are well ... both dental and medical professionals. , That,s one of the ... conducted on behalf of Delta Dental Plans Association, the nation,s ... gain greater knowledge about the state of children,s oral health. ...
... Incorporated (NYSE: HR ) announced it has entered into ... previous $400 million facility. The new facility includes 16 ... priced at 2.80% over LIBOR, with a 0.40% facility fee, ... loans of this nature. , Healthcare Realty Trust ...
... TOLEDO, Ohio, Sept. 30 Heartland Information Services, a ... Brett S. Himes to President and Chief Executive Officer. ... will assume the President and CEO position immediately. , ... C. Cirino, who has accepted a new position with ...
... Walter and Eliza Hall Institute researchers have put an ... a molecular messenger called Fas ligand is responsible for ... Apoptosis is an important process in human biology ... bodies, protecting us against cancer development and diseases where ...
Cached Medicine News:Health News:Study Urges Treatment for Even Mild Gestational Diabetes 2Health News:Study Urges Treatment for Even Mild Gestational Diabetes 3Health News:Boston Biotech R&D Conference to Showcase Next-Generation Newsmakers and Massachusetts as Leader in Biotech Discovery 2Health News:Boston Biotech R&D Conference to Showcase Next-Generation Newsmakers and Massachusetts as Leader in Biotech Discovery 3Health News:Delayed First Visit to Dentist Can Affect Children's Lifelong Oral Health 2Health News:Healthcare Realty Trust Announces New $550 Million Unsecured Revolving Credit Facility 2Health News:Heartland Information Services Appoints New Chief Executive Officer 2Health News:Research puts a 'Fas' to the cause of programmed cell death 2
(Date:9/22/2014)... MEDICAL CORP. (NYSE: CMN ) will release  the ... 31, 2014 on Monday, September 29 before the market opens, ... 11:00 AM ET. Participating in the call will be ... President and CEO; Jorgen B. Hansen , Executive Vice ... President, CFO and Treasurer; and Seth Yellin , Senior ...
(Date:9/22/2014)... Sept. 22, 2014  For many people experiencing ... means facing the prospect of large, painful incisions ... regular activities are also impacted, such as working, ... of the problem, some patients even delay necessary ... even lead to permanent damage for some conditions. ...
(Date:9/22/2014)... 22, 2014  Inovio Pharmaceuticals, Inc. (NASDAQ: ... a phase I clinical trial in patients with ... tolerability, and immunogenicity of INO-3106. This immunotherapy targets ... aerodigestive cancers. Aerodigestive cancers affect the ... parts of the esophagus and windpipe. The unmet ...
Breaking Medicine Technology:Cantel Medical Corp. To Hold Conference Call To Discuss Results For Its Fourth Quarter And Fiscal 2014 Ended July 31, 2014 2Phoenix Arizona Hand Doctor Develops Revolutionary New Surgery System, Eliminates Need for Large Incisions 2Inovio Pharmaceuticals Expands HPV Immunotherapy Development to Aerodigestive Cancers 2Inovio Pharmaceuticals Expands HPV Immunotherapy Development to Aerodigestive Cancers 3Inovio Pharmaceuticals Expands HPV Immunotherapy Development to Aerodigestive Cancers 4
... (Nasdaq: REGN ) (the "Company"), today announced that ... of its common stock pursuant to an underwriting agreement with ... Company expects to use the net proceeds from the sale ... offering is expected to occur on or about October 11, ...
... at Self Regional Healthcare,s South Carolina Spine Center in ... of spinal conditions in its new advanced surgical operating ... Already recognized by leading health care ratings organization HealthGrades ... its commitment to advanced spinal care by becoming the ...
Cached Medicine Technology:Regeneron Pharmaceuticals, Inc. Announces The Sale of 4,500,000 Shares of Common Stock 2Regeneron Pharmaceuticals, Inc. Announces The Sale of 4,500,000 Shares of Common Stock 3Self Regional Healthcare Becomes First in the Southeast to Treat Spine Patients Using Advanced Integrated Operating Room Technology From Brainlab 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: